Fellow and Resident Radiation Oncology iNtensive Training in Imaging and Informatics to Empower Research Careers (FRONTI2ER)

放射肿瘤学研究员和住院医师影像和信息学强化培训，以促进研究职业发展 (FRONTI2ER)

• 批准号: 10477438
• 负责人: Prajnan Das
• 金额: $ 15.28万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10477438
• 关键词: Address; Adopted; Award; Basic Science; Big Data; Biological Sciences; Biomedical Research; Caliber; Cancer Center; Caring; Clinical Informatics; Clinical Research; Clinical Trials; Clinical Trials Design; Data; Detection; Development; Disease; Economically Deprived Population; Engineering; Evolution; Fellowship; Floods; Functional Magnetic Resonance Imaging; Funding; Future; Generations; Genomics; Goals; Health; Healthcare; Human; Human Resources; Image; Image Analysis; Imaging Device; Imaging Techniques; Individual; Informatics; Institutes; Instruction; Knowledge; Label; Lead; Link; Magnetic Resonance Imaging; Malignant Neoplasms; Medical; Mentors; Mission; Monitor; National Institute of Biomedical Imaging and Bioengineering; Outcome; Patients; Phase; Physicians; Positron-Emission Tomography; Prevention strategy; Productivity; Radiation Oncologist; Radiation Oncology; Radiation therapy; Radioactive; Research; Research Activity; Research Personnel; Research Training; Residencies; Science; Scientist; Structure; Therapeutic; Training; Training Programs; Training and Education; Treatment-related toxicity; Underrepresented Minority; United States National Institutes of Health; University of Texas M D Anderson Cancer Center; biomedical imaging; cancer therapy; career; career development; clinical imaging; clinical implementation; cohort; design; disability; disorder prevention; educationally disadvantaged; experience; genome sciences; genomic data; image guided; image-guided radiation; imaging detection; imaging informatics; improved; individual patient; individual variation; innovation; novel; precision medicine; programs; radiomics; recruit; skills; social; tomography; translational approach; treatment planning; treatment strategy; tumor

PROJECT SUMMARY The current proposal entitled "Fellow and Resident Radiation Oncology iNtensive Training in Imaging and Informatics to Empower Research Careers (FRONTI2ER)” is particularly designed to develop radiation oncology training program of excellence that emphasizes mentored research training of biomedical imaging, informatics, and clinical trial design for residents/fellows at The University of Texas MD Anderson Cancer Center, with the intent to create a generation of radiation oncology physician scientists who will become independent research investigators and leaders in academic biomedical imaging and clinical informatics, and to innovate translational scientific research linking advances in the sciences of genomics/radiomics with ongoing technological evolution in biomedical imaging and clinical informatics. The University of Texas MD Anderson Cancer Center is the largest domestic radiation oncology training program and has specific personnel with direct formal expertise in imaging, clinical informatics, and clinical trial design, in the context of a radiation oncology educational program. To this end, and pursuant to the RFA (PAR-15-167), we propose a program to enhance the training of radiation oncologist physician scientists during the early phase of their training program (residency/fellowship) by introducing a formal one-year educational and research program that will effectuate expertise sufficient to lead and accelerate the development of biomedical imaging application in radiation oncology. We aim to develop and effectuate a program that includes a mentored education, training, and hands-on implementation of research activities related to biomedical imaging, clinical informatics, and clinical trial design and to enhance the recruitment of early career physician scientist from under-represented minorities or with disabilities or other social, cultural, economic, or educational disadvantages to enrich the diversity of our national workforce in biomedical imaging. Successful implementation of this program will directly augment novel research approaches towards the development of new biomedical imaging techniques and devices to fundamentally improve the detection, treatment, and prevention of disease; as well as enhancing existing imaging and clinical research and its implications.

项目摘要 目前的提案题为“研究员和住院放射肿瘤学在成像和 信息学赋予研究事业（FRONTI 2 ER）”是特别设计来发展辐射 卓越的肿瘤学培训计划，强调生物医学成像的指导研究培训， 信息学和临床试验设计的居民/研究员在得克萨斯大学医学博士安德森癌症 中心，旨在创造一代放射肿瘤学医生科学家，他们将成为 学术生物医学成像和临床信息学的独立研究者和领导者，以及 创新转化科学研究，将基因组学/放射组学的进步与 生物医学成像和临床信息学的持续技术发展。德克萨斯大学MD 安德森癌症中心是国内最大的放射肿瘤学培训计划， 具有成像、临床信息学和临床试验设计方面直接正式专业知识的人员， 放射肿瘤学教育项目为此，根据RFA（PAR-15-167），我们提出了一个 计划，以加强培训的放射肿瘤学家医生科学家在早期阶段， 通过引入正式的为期一年的教育和研究计划， 这将实现足够的专业知识，以领导和加速生物医学成像的发展， 在放射肿瘤学中的应用。我们的目标是制定和实施一个计划，其中包括一个指导 教育，培训和实践与生物医学成像，临床 信息学和临床试验设计，并加强招聘早期职业医生科学家， 代表性不足的少数群体或残疾人或其他社会、文化、经济或教育 我们的目标是消除各种不利因素，以丰富我国生物医学成像领域劳动力的多样性。成功 该计划的实施将直接增加新的研究方法， 新的生物医学成像技术和设备，从根本上提高检测，治疗， 预防疾病;以及加强现有的成像和临床研究及其影响。

项目成果

Stereotactic body ablative radiotherapy for reirradiation of small volume head and neck cancers is associated with prolonged survival: Large, single-institution, modern cohort study.

• DOI: 10.1002/hed.26820
• 发表时间: 2021-11
• 期刊: Head & neck
• 作者: Diao K;Nguyen TP;Moreno AC;Reddy JP;Garden AS;Wang CH;Tung S;Wang C;Wang XA;Rosenthal DI;Fuller CD;Gunn GB;Frank SJ;Morrison WH;Shah SJ;Lee A;Spiotto MT;Su SY;Ferrarotto R;Phan J
• 通讯作者: Phan J

Radiomics feature stability of open-source software evaluated on apparent diffusion coefficient maps in head and neck cancer.

• DOI: 10.1038/s41598-021-96600-4
• 发表时间: 2021-09-03
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Korte JC;Cardenas C;Hardcastle N;Kron T;Wang J;Bahig H;Elgohari B;Ger R;Court L;Fuller CD;Ng SP
• 通讯作者: Ng SP

Predicting treatment Response based on Dual assessment of magnetic resonance Imaging kinetics and Circulating Tumor cells in patients with Head and Neck cancer (PREDICT-HN): matching 'liquid biopsy' and quantitative tumor modeling.

• DOI: 10.1186/s12885-018-4808-5
• 发表时间: 2018-09-19
• 期刊: BMC cancer
• 影响因子: 3.8
• 作者: Ng SP;Bahig H;Wang J;Cardenas CE;Lucci A;Hall CS;Meas S;Sarli VN;Yuan Y;Urbauer DL;Ding Y;Ikner S;Dinh V;Elgohari BA;Johnson JM;Skinner HD;Gunn GB;Garden AS;Phan J;Rosenthal DI;Morrison WH;Frank SJ;Hutcheson KA;Mohamed ASR;Lai SY;Ferrarotto R;MacManus MP;Fuller CD
• 通讯作者: Fuller CD

Career Enrichment Opportunities at the Scientific Frontier in Radiation Oncology.

放射肿瘤学科学前沿的职业丰富机会。

• DOI: 10.1200/cci.18.00126
• 发表时间: 2019
• 期刊: JCO clinical cancer informatics
• 影响因子: 4.2
• 作者: Thompson,ReidF;Fuller,CliftonD;Berman,AbigailT;Aneja,Sanjay;ThomasJr,CharlesR
• 通讯作者: ThomasJr,CharlesR

Toxicity Profiles and Survival Outcomes Among Patients With Nonmetastatic Nasopharyngeal Carcinoma Treated With Intensity-Modulated Proton Therapy vs Intensity-Modulated Radiation Therapy.

• DOI: 10.1001/jamanetworkopen.2021.13205
• 发表时间: 2021-06-01
• 期刊: JAMA network open
• 影响因子: 13.8
• 作者: Li X;Kitpanit S;Lee A;Mah D;Sine K;Sherman EJ;Dunn LA;Michel LS;Fetten J;Zakeri K;Yu Y;Chen L;Kang JJ;Gelblum DY;McBride SM;Tsai CJ;Riaz N;Lee NY
• 通讯作者: Lee NY