Penn Skin Biology and Diseases Resource-based Center

宾夕法尼亚大学皮肤生物学和疾病资源中心

• 批准号: 10477227
• 负责人: Elizabeth Anne Grice
• 金额: $ 81.25万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10477227
• 关键词: Academy; Advisory Committees; Bioinformatics; Biology; Biomedical Research; Blood specimen; Budgets; Cells; Clinic; Clinical; Collaborations; Communities; Community Outreach; Cutaneous; Data Science; Dermatologist; Dermatology; Diagnosis; Discipline; Disease; Disease model; Educational workshop; Ensure; Environment; Evaluation; Experimental Designs; Faculty; Financial Support; Fostering; Funding; Funding Mechanisms; Funding Opportunities; Future; Genomics; Goals; Health; High School Student; Histologic; Human; Informatics; Infrastructure; Innovative Therapy; Interdisciplinary Study; Investigation; Laboratories; Learning; Logistics; Medicine; Mentors; Mentorship; Minority Women; Molecular; Monitor; Patients; Pennsylvania; Phenotype; Philadelphia; Positioning Attribute; Prevention; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Schools; Seeds; Series; Services; Skin; Structure; Surveys; Techniques; Technology; Testing; Tissues; Training; Translating; Translational Research; Translations; Underrepresented Minority; Woman; base; career; design; diversity and inclusion; effectiveness evaluation; experimental study; imaging approach; improved; innovation; intravital imaging; lectures; member; multidisciplinary; new technology; next generation; operation; personalized approach; phenomics; programs; research study; skin disorder; success; summer internship; symposium; tissue resource; transcriptomics; volunteer

PROJECT SUMMARY The Penn Skin Biology and Diseases Resource-based Center (Penn SBDRC) will continue to support and accelerate skin disease research and its translation by providing critical infrastructure, resources, and expertise to skin investigators. The overall goals of the Penn SBDRC are to promote collaboration among skin investigators, especially across disciplines; to draw new investigators with diverse perspectives to skin research; to foster an environment that supports and cultivates the next generation of skin researchers; to increase access to technology and resources for conducting rigorous, impactful skin research; and to accelerate translation of research findings into innovative therapies for skin disease. To accomplish these goals, the aims of the Center are: Aim 1) To provide cutting-edge approaches and related expertise centered around 3 multi-disciplinary Resource Cores: Cutaneous Phenomics and Transcriptomics (CPAT) Core, Skin Translational Research (STaR) Core, and Data Science and Informatics (DSI) Core. These Cores are highly synergistic, providing high-demand and/or specialized services, valuable tissue/cellular resources, and the expertise to ensure rigorous experimental design, analytical strategies, and accurate interpretations. All Cores take advantage of the deep expertise of the Directors and Co-Directors and their research groups, to continuously improve and innovate upon techniques/approaches offered by the Center. Aim 2) To establish an Administrative Core that unifies skin investigators and promotes the goals of the SBDRC. The Administrative Core provides oversight and implements the activities of the center. This includes an Enrichment Program that is subdivided into 4 Sub-Cores: The Community Outreach Sub-Core introduces underserved Philadelphia public high school students to the excitement of biomedical research and dermatology through the Penn Academy of Skin Health (PASH), a Saturday academy and summer internship program. These programs also provide volunteer and mentorship opportunities for SBDRC members; The Mentoring Sub-Core promotes career success and training through structured mentorship for trainees and junior faculty. Through a partnership with the Dermatology Department’s Committee on Diversity and Inclusion, specialized mentoring programs for women and minorities underrepresented in medicine will be provided, as well as training for SBDRC mentors. The Scientific Enrichment Sub-Core sponsors a seminar series, workshops, and a yearly scientific symposium to promote interactions, collaboration, and innovative approaches among skin researchers. The Seed Funding Sub-Core offers 3 different funding mechanisms that attract new investigators and support the independence of junior investigators. The Penn SBDRC leverages the excellence of Penn Dermatology’s research and clinical programs as well as that of the entire Penn community to enhance collaboration, bringing new technology to skin research, and providing access to critical intellectual and technical resources that greatly enhance innovation and rigor in the study of skin disease. The Center impacts skin research well beyond Pennsylvania’s borders, and ultimately advances the treatment, prevention, and diagnosis of skin diseases.

项目总结 宾夕法尼亚大学皮肤生物学和疾病资源中心(宾夕法尼亚州立大学SBDRC)将继续支持和 通过提供关键基础设施、资源和专业知识，加快皮肤病研究及其翻译 去剥调查人员的皮。宾夕法尼亚州立大学SBDRC的总体目标是促进皮肤之间的合作 研究人员，特别是跨学科的；吸引对皮肤有不同视角的新调查人员 研究；营造支持和培养下一代皮肤研究人员的环境； 增加获得技术和资源的机会，以进行严谨、有影响力的皮肤研究； 加快将研究成果转化为皮肤病的创新疗法。要实现这些目标 目标，中心的目标是：目标1)提供最先进的方法和以 大约3个多学科资源核心：皮肤表型组学和转录组学(CPAT)核心、皮肤 翻译研究(STAR)核心和数据科学与信息学(DSI)核心。这些核心高度 协同作用，提供高需求和/或专业化服务、宝贵的组织/细胞资源，以及 确保严谨的实验设计、分析策略和准确解释的专业知识。所有核心 利用董事和联席董事及其研究小组的深厚专业知识， 在中心提供的技术/方法上不断改进和创新。目标2)建立一个 管理核心，统一皮肤调查人员并促进SBDRC的目标。行政部门 CORE负责监督和实施中心的活动。这包括一项丰富计划， 被细分为4个子核心：社区外展子核心介绍服务不足的费城 通过宾夕法尼亚大学让公立高中生对生物医学研究和皮肤病研究感到兴奋 皮肤健康学院(PASH)，周六学院和暑期实习计划。这些计划还包括 为SBDRC成员提供志愿者和导师机会；导师分核心促进 通过为受训者和初级教员提供有组织的指导，实现职业成功和培训。通过一个 与皮肤科的多样性和包容性、专业指导委员会建立伙伴关系 将为在医疗方面任职人数不足的妇女和少数群体提供方案，并为 SBDRC导师。科学浓缩分核心主办一系列研讨会、讲习班和每年一次的 促进皮肤之间的互动、协作和创新方法的科学研讨会 研究人员。种子基金分核心提供了3种不同的融资机制，以吸引新的研究人员 并支持初级调查人员的独立性。宾夕法尼亚州立大学SBDRC充分利用宾夕法尼亚大学的优势 皮肤科的研究和临床计划以及整个宾夕法尼亚社区的研究和临床计划 协作，将新技术引入皮肤研究，并提供访问关键的智力和 极大地提高了皮肤病研究的创新性和严谨性的技术资源。中心的影响 皮肤研究远远超出了宾夕法尼亚州的边界，并最终推动了治疗、预防和 皮肤病的诊断。