Penn Skin Biology and Diseases Resource-based Center

宾夕法尼亚大学皮肤生物学和疾病资源中心

• 批准号: 10663977
• 负责人: Elizabeth Anne Grice
• 金额: $ 81.24万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663977
• 关键词: Academy; Acceleration; Advisory Committees; Bioinformatics; Biology; Biomedical Research; Blood specimen; Budgets; Cells; Clinic; Clinical; Collaborations; Communication; Communities; Community Outreach; Cutaneous; Data Science; Dermatologist; Dermatology; Diagnosis; Discipline; Disease; Disease model; Educational workshop; Ensure; Environment; Evaluation; Experimental Designs; Faculty; Financial Support; Fostering; Funding; Funding Mechanisms; Funding Opportunities; Future; Genomics; Goals; Health; High School Student; Histologic; Human; Informatics; Infrastructure; Innovative Therapy; Interdisciplinary Study; Investigation; Laboratories; Learning; Medicine; Mentors; Mentorship; Molecular; Monitor; Patients; Pennsylvania; Phenotype; Philadelphia; Positioning Attribute; Prevention; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Schools; Series; Services; Skin; Structure; Surveys; Techniques; Technology; Tissues; Training; Translating; Translational Research; Translations; Underrepresented Minority; Woman; barrier to testing; career; design; diversity and inclusion; effectiveness evaluation; experimental study; imaging approach; improved; innovation; intravital imaging; lectures; member; multidisciplinary; new technology; next generation; operation; personalized approach; phenomics; programs; research study; skin disorder; success; summer internship; symposium; tissue resource; transcriptomics; volunteer

PROJECT SUMMARY The Penn Skin Biology and Diseases Resource-based Center (Penn SBDRC) will continue to support and accelerate skin disease research and its translation by providing critical infrastructure, resources, and expertise to skin investigators. The overall goals of the Penn SBDRC are to promote collaboration among skin investigators, especially across disciplines; to draw new investigators with diverse perspectives to skin research; to foster an environment that supports and cultivates the next generation of skin researchers; to increase access to technology and resources for conducting rigorous, impactful skin research; and to accelerate translation of research findings into innovative therapies for skin disease. To accomplish these goals, the aims of the Center are: Aim 1) To provide cutting-edge approaches and related expertise centered around 3 multi-disciplinary Resource Cores: Cutaneous Phenomics and Transcriptomics (CPAT) Core, Skin Translational Research (STaR) Core, and Data Science and Informatics (DSI) Core. These Cores are highly synergistic, providing high-demand and/or specialized services, valuable tissue/cellular resources, and the expertise to ensure rigorous experimental design, analytical strategies, and accurate interpretations. All Cores take advantage of the deep expertise of the Directors and Co-Directors and their research groups, to continuously improve and innovate upon techniques/approaches offered by the Center. Aim 2) To establish an Administrative Core that unifies skin investigators and promotes the goals of the SBDRC. The Administrative Core provides oversight and implements the activities of the center. This includes an Enrichment Program that is subdivided into 4 Sub-Cores: The Community Outreach Sub-Core introduces underserved Philadelphia public high school students to the excitement of biomedical research and dermatology through the Penn Academy of Skin Health (PASH), a Saturday academy and summer internship program. These programs also provide volunteer and mentorship opportunities for SBDRC members; The Mentoring Sub-Core promotes career success and training through structured mentorship for trainees and junior faculty. Through a partnership with the Dermatology Department’s Committee on Diversity and Inclusion, specialized mentoring programs for women and minorities underrepresented in medicine will be provided, as well as training for SBDRC mentors. The Scientific Enrichment Sub-Core sponsors a seminar series, workshops, and a yearly scientific symposium to promote interactions, collaboration, and innovative approaches among skin researchers. The Seed Funding Sub-Core offers 3 different funding mechanisms that attract new investigators and support the independence of junior investigators. The Penn SBDRC leverages the excellence of Penn Dermatology’s research and clinical programs as well as that of the entire Penn community to enhance collaboration, bringing new technology to skin research, and providing access to critical intellectual and technical resources that greatly enhance innovation and rigor in the study of skin disease. The Center impacts skin research well beyond Pennsylvania’s borders, and ultimately advances the treatment, prevention, and diagnosis of skin diseases.

项目摘要 宾州皮肤生物学和疾病资源中心（Penn SBDRC）将继续支持和 通过提供关键基础设施、资源和专业知识，加速皮肤病研究及其转化 给调查员剥皮宾州SBDRC的总体目标是促进皮肤之间的合作， 研究人员，特别是跨学科的研究人员;吸引具有不同视角的新研究人员来皮肤 研究;培养支持和培养下一代皮肤研究人员的环境; 增加获得技术和资源的机会，以进行严格，有影响力的皮肤研究;以及 加速将研究成果转化为皮肤病的创新疗法。完成这些 目标，该中心的目标是：目标1）提供尖端的方法和相关的专业知识为中心 围绕3个多学科资源核心：皮肤表型组学和转录组学（CPAT）核心，皮肤 转化研究（STaR）核心和数据科学与信息学（DSI）核心。这些核心高度 协同，提供高需求和/或专业服务，有价值的组织/细胞资源，以及 专业知识，以确保严格的实验设计，分析策略和准确的解释。所有内核 利用董事和联席董事及其研究小组的深厚专业知识， 不断改进和创新中心提供的技术/方法。目标2）建立一个 管理核心，统一皮肤调查和促进SBDRC的目标。行政 核心提供监督和实施中心的活动。这包括一个丰富的计划， 被细分为4个子核心：社区外展子核心介绍服务不足的费城 公立高中的学生通过宾夕法尼亚大学的生物医学研究和皮肤病学的兴奋 皮肤健康学院（PASH），一个星期六的学院和夏季实习计划。这些方案还 为SBDRC成员提供志愿者和指导机会;指导子核心促进 通过为学员和初级教师提供结构化的指导，实现职业成功和培训。通过 与皮肤科部门的多样性和包容性委员会合作， 将为在医学领域代表性不足的妇女和少数民族提供项目，并为 SBDRC导师。科学充实分核心赞助了一系列研讨会、讲习班和一年一次的 科学研讨会，以促进皮肤之间的互动，合作和创新方法 研究人员种子资金子核心提供3种不同的资金机制，吸引新的研究人员 支持初级调查员的独立性。宾夕法尼亚大学SBDRC利用宾夕法尼亚大学的卓越 皮肤科的研究和临床计划，以及整个宾州社区，以提高 合作，为皮肤研究带来新技术，并提供关键的知识和 技术资源，大大提高了皮肤病研究的创新性和严谨性。中心影响 皮肤研究远远超出宾夕法尼亚州的边界，并最终推进治疗，预防， 皮肤病的诊断。

项目成果

Ablative fractional laser resurfacing for treatment of sclerosis and contractures in chronic graft-versus-host disease: A pilot study.

烧蚀点阵激光换肤治疗慢性移植物抗宿主病的硬化和挛缩：一项试点研究。

• DOI: 10.1016/j.jaad.2019.07.084
• 发表时间: 2020
• 期刊: Journal of the American Academy of Dermatology
• 影响因子: 13.8
• 作者: Micheletti,RobertG;Chansky,PeterB;Haun,PaulL;Seykora,JohnT;Dekerlegand,Jennifer;Sultan,LaithR;Schultz,SusanM;Sehgal,ChandraM;Sobanko,JosephF
• 通讯作者: Sobanko,JosephF

Engineering Cell Therapies for Autoimmune Diseases: From Preclinical to Clinical Proof of Concept.

• DOI: 10.4110/in.2022.22.e37
• 发表时间: 2022-10
• 期刊: Immune network
• 影响因子: 6
• 作者: Oh S;Payne AS
• 通讯作者: Payne AS

Rho Kinase regulates neutrophil NET formation that is involved in UVB-induced skin inflammation.

• DOI: 10.7150/thno.66457
• 发表时间: 2022
• 期刊: Theranostics
• 影响因子: 12.4
• 作者: Li M;Lyu X;Liao J;Werth VP;Liu ML
• 通讯作者: Liu ML

Risks of Multiple Skin Cancers in Organ Transplant Recipients: A Cohort Study in 2 Administrative Data Sets.

器官移植受者患多种皮肤癌的风险：2 个管理数据集的队列研究。

• DOI: 10.1001/jamadermatol.2021.4148
• 发表时间: 2021
• 期刊: JAMA dermatology
• 影响因子: 10.9
• 作者: Wehner,MackenzieR;Niu,Jiangong;Wheless,Lee;Baker,LauraX;Cohen,OliviaG;Margolis,DavidJ;Giordano,SharonH;Shin,ThuzarM
• 通讯作者: Shin,ThuzarM

Prevalence of clinically significant incidental findings by whole-body fludeoxyglucose F 18 positron emission tomography/computed tomography scanning in moderate-to-severe psoriasis patients participating in clinical trials.

在参加临床试验的中重度银屑病患者中，通过全身氟脱氧葡萄糖 F 18 正电子发射断层扫描/计算机断层扫描发现具有临床意义的偶然发现的发生率。

• DOI: 10.1016/j.jaad.2019.01.008
• 发表时间: 2019
• 期刊: Journal of the American Academy of Dermatology
• 影响因子: 13.8
• 作者: Wan,MarilynT;Torigian,DrewA;Alavi,Abass;Alvarez,Judith;ChiesaFuxench,ZelmaC;Noe,MeganH;Papadopoulos,Maryte;Shin,DanielB;Takeshita,Junko;Werner,ThomasJ;Mehta,NehalN;Gelfand,JoelM
• 通讯作者: Gelfand,JoelM