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Skin Translational Research

皮肤转化研究

基本信息

批准号：
10477231
负责人：
Aimee S Payne
金额：
$ 13.96万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-15 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10477231
关键词：
3-Dimensional Age Applications Grants B-Lymphocytes Biological Biological Assay Biology Blood specimen Cell Line Cell physiology Cells Clinical Clinical Data Clustered Regularly Interspaced Short Palindromic Repeats Collaborations Communities Computerized Medical Record Consultations Data Dermatology Disease Disease model Drug Delivery Systems Evaluation FDA approved Fibroblasts Fostering Freezing Future Genetic Engineering Genetic Screening Genomics Genotype Goals Grant Human Immunodeficient Mouse Inflammatory Informed Consent Infrastructure Institution Institutional Review Boards Investigation Learning Link Manuscripts Medical Medical Genetics Medicine Modeling Molecular Abnormality Participant Pathway interactions Patients Pharmacology and Toxicology Phenotype Publications Research Research Infrastructure Research Personnel Research Support Resources Robotics Sampling Services Site Skin Skin Physiology Skin Tissue Small Interfering RNA Technology Tissue Engineering Tissues Training Translational Research base biobank body system chemical genetics efficacy evaluation exome experience experimental study functional adaptation high throughput screening human disease in vitro Model in vivo in vivo Model innovation interest keratinocyte melanocyte neoplastic novel novel therapeutics sex skin disorder skin xenograft small hairpin RNA small molecule small molecule libraries stem targeted treatment transcriptomics

项目摘要

PROJECT SUMMARY The Skin Translational Research (STaR) Core aims to foster innovative and pathophysiologically relevant skin biology and disease research by facilitating experiments using human primary samples. Fresh human skin and primary skin cells are highly valuable resources that help to extend skin research throughout the larger scientific community at our institution, evidenced by the large number of investigators outside the Department of Dermatology who have previously used our Core services and subsequently submitted new abstracts, publications, and grant applications on skin biology. By combining highly utilized primary tissue services with innovative tissue engineering, high-throughput screening, and biobanking consultation and services, STaR Core aims to maximize our impact within an even broader scientific community. Our long-term objectives are to: (1) allow investigators both within and outside the Department of Dermatology to conduct research on skin biology more efficiently and effectively by centralizing high-volume or specialized technical services and providing the critical research infrastructure and institutional review board approvals for their use; (2) foster innovative exploratory projects and junior investigators in skin biology through our core services, with the goal of promoting new scientific collaborations, abstracts, manuscripts, and grants; (3) promote translational research by providing access to normal and diseased human skin samples that might not otherwise be available to non-physicians or have substantial administrative barriers to their use; and (4) integrate our core directors’ research expertise into future core services to adapt to the emerging needs and opportunities of our membership. To accomplish these goals we aim to: 1) Accelerate novel pathway discovery through both targeted investigations of candidate pathways as well as unbiased high-throughput screening assays in primary human skin cells; 2) Enable 3-dimensional skin biology and disease modeling through ex vivo human skin cultures, organotypic skin cultures, and human skin xenografts; and 3) Promote research using well- annotated skin biospecimens by establishing the Penn Dermatology BioBank, which includes both normal and diseased human skin samples, with or without paired blood samples, including linked clinical and genetic data.

项目概要皮肤转化研究 (STaR) 核心旨在培育创新且与病理生理学相关的皮肤通过促进使用人类原始样本的实验来进行生物学和疾病研究。新鲜的人体皮肤和原代皮肤细胞是非常有价值的资源，有助于将皮肤研究扩展到更大范围我们机构的科学界，部门外的大量研究人员就证明了这一点之前使用过我们的核心服务并随后提交了新摘要的皮肤科医师，皮肤生物学方面的出版物和资助申请。通过将高度利用的初级组织服务与创新组织工程、高通量筛选以及生物样本库咨询和服务，STaR Core 的目标是在更广泛的科学界中最大限度地发挥我们的影响力。我们的长期目标是 (1) 允许皮肤科内外的研究人员进行皮肤研究通过集中大量或专门的技术服务和提供关键的研究基础设施并获得机构审查委员会的使用批准； (2)寄养通过我们的核心服务开展皮肤生物学方面的创新探索项目和初级研究人员，其目标促进新的科学合作、摘要、手稿和资助；（三）促进转化通过提供正常和患病的人类皮肤样本来进行研究，否则这些样本可能无法获得可供非医生使用或对其使用存在重大行政障碍； (4) 整合我们的核心董事对未来核心服务的研究专业知识，以适应我们新兴的需求和机遇会员资格。为了实现这些目标，我们的目标是：1）通过以下途径加速新途径的发现对候选途径进行有针对性的研究以及公正的高通量筛选分析人类原代皮肤细胞； 2) 通过离体人体实现 3 维皮肤生物学和疾病建模皮肤培养、器官型皮肤培养和人类皮肤异种移植； 3）利用良好的方法促进研究通过建立宾夕法尼亚大学皮肤病学生物库来注释皮肤生物样本，其中包括正常和患病的人类皮肤样本，有或没有配对的血液样本，包括相关的临床和遗传数据。