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Skin Translational Research

皮肤转化研究

基本信息

批准号：
10477231
负责人：
Aimee S Payne
金额：
$ 13.96万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-15 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10477231
关键词：
3-Dimensional Age Applications Grants B-Lymphocytes Biological Biological Assay Biology Blood specimen Cell Line Cell physiology Cells Clinical Clinical Data Clustered Regularly Interspaced Short Palindromic Repeats Collaborations Communities Computerized Medical Record Consultations Data Dermatology Disease Disease model Drug Delivery Systems Evaluation FDA approved Fibroblasts Fostering Freezing Future Genetic Engineering Genetic Screening Genomics Genotype Goals Grant Human Immunodeficient Mouse Inflammatory Informed Consent Infrastructure Institution Institutional Review Boards Investigation Learning Link Manuscripts Medical Medical Genetics Medicine Modeling Molecular Abnormality Participant Pathway interactions Patients Pharmacology and Toxicology Phenotype Publications Research Research Infrastructure Research Personnel Research Support Resources Robotics Sampling Services Site Skin Skin Physiology Skin Tissue Small Interfering RNA Technology Tissue Engineering Tissues Training Translational Research base biobank body system chemical genetics efficacy evaluation exome experience experimental study functional adaptation high throughput screening human disease in vitro Model in vivo in vivo Model innovation interest keratinocyte melanocyte neoplastic novel novel therapeutics sex skin disorder skin xenograft small hairpin RNA small molecule small molecule libraries stem targeted treatment transcriptomics

项目摘要

PROJECT SUMMARY The Skin Translational Research (STaR) Core aims to foster innovative and pathophysiologically relevant skin biology and disease research by facilitating experiments using human primary samples. Fresh human skin and primary skin cells are highly valuable resources that help to extend skin research throughout the larger scientific community at our institution, evidenced by the large number of investigators outside the Department of Dermatology who have previously used our Core services and subsequently submitted new abstracts, publications, and grant applications on skin biology. By combining highly utilized primary tissue services with innovative tissue engineering, high-throughput screening, and biobanking consultation and services, STaR Core aims to maximize our impact within an even broader scientific community. Our long-term objectives are to: (1) allow investigators both within and outside the Department of Dermatology to conduct research on skin biology more efficiently and effectively by centralizing high-volume or specialized technical services and providing the critical research infrastructure and institutional review board approvals for their use; (2) foster innovative exploratory projects and junior investigators in skin biology through our core services, with the goal of promoting new scientific collaborations, abstracts, manuscripts, and grants; (3) promote translational research by providing access to normal and diseased human skin samples that might not otherwise be available to non-physicians or have substantial administrative barriers to their use; and (4) integrate our core directors’ research expertise into future core services to adapt to the emerging needs and opportunities of our membership. To accomplish these goals we aim to: 1) Accelerate novel pathway discovery through both targeted investigations of candidate pathways as well as unbiased high-throughput screening assays in primary human skin cells; 2) Enable 3-dimensional skin biology and disease modeling through ex vivo human skin cultures, organotypic skin cultures, and human skin xenografts; and 3) Promote research using well- annotated skin biospecimens by establishing the Penn Dermatology BioBank, which includes both normal and diseased human skin samples, with or without paired blood samples, including linked clinical and genetic data.

项目总结皮肤转化研究(STAR)的核心目标是培养创新和病理生理相关的皮肤通过促进使用人类初级样本的实验，进行生物学和疾病研究。新鲜的人类皮肤和原代皮肤细胞是非常有价值的资源，有助于将皮肤研究扩展到更大的我们机构的科学界，新闻部外的大量调查人员证明了这一点之前使用过我们的核心服务并随后提交了新摘要的皮肤科医生，出版，并授予皮肤生物学方面的应用。通过将高利用率的初级组织服务与创新的组织工程、高通量筛查以及生物库咨询和服务，STAR CORE的目标是最大限度地扩大我们在更广泛的科学界中的影响。我们的长期目标是：(1)允许皮肤科内外的调查人员对皮肤进行研究通过集中大量或专业的技术服务和提供关键的研究基础设施和机构审查委员会批准其使用；(2)促进通过我们的核心服务，在皮肤生物学方面进行创新的探索性项目和初级研究人员，目标是促进新的科学合作、摘要、手稿和资助；(3)促进翻译通过提供正常和患病的人类皮肤样本进行研究，否则这些样本可能不会向非内科医生提供或对其使用存在重大行政障碍；以及(4)整合我们的核心董事对未来核心服务的研究专长，以适应我们的新需求和机遇会员制。为了实现这些目标，我们的目标是：1)通过以下两种途径加速新途径的发现对候选途径的有针对性的调查以及无偏见的高通量筛选试验原代人类皮肤细胞；2)通过体外人类实现三维皮肤生物学和疾病建模皮肤培养、器官型皮肤培养和人类皮肤移植；以及3)利用良好的通过建立宾夕法尼亚大学皮肤病生物库来标注皮肤生物样本，该数据库包括正常和患病的人类皮肤样本，有或没有配对血液样本，包括相关的临床和基因数据。