Skin Translational Research

项目摘要 皮肤转化研究（星星）核心旨在促进创新和病理生理相关的皮肤 生物学和疾病研究，促进实验使用人类的原始样本。新鲜的人皮， 原代皮肤细胞是非常宝贵的资源，有助于将皮肤研究扩展到整个大城市。 科学界在我们的机构，证明了大量的调查人员以外的部门 曾使用过我们的核心服务并随后提交了新摘要的皮肤科医生， 出版物，并在皮肤生物学的赠款申请。通过将高利用率的初级组织服务与 创新组织工程、高通量筛选和生物库咨询与服务 核心旨在最大限度地提高我们在更广泛的科学界的影响。我们的长期目标是 （1）允许皮肤科内外的研究人员进行皮肤研究 通过集中大量或专门的技术服务， 提供关键研究基础设施和机构审查委员会对其使用的批准;（2）促进 通过我们的核心服务，为皮肤生物学领域的创新探索性项目和初级研究人员提供服务， 促进新的科学合作，摘要，手稿和赠款;（3）促进翻译 通过提供正常和患病的人类皮肤样本， 提供给非医生或有实质性的行政障碍，以他们的使用;和（4）整合我们的核心 董事的研究专业知识，以适应未来的核心服务，以适应新兴的需求和机会， 会员资格为了实现这些目标，我们的目标是：1）通过以下两种途径加速新途径的发现： 候选途径的靶向研究以及无偏倚的高通量筛选试验， 2）能够通过离体人皮肤细胞进行三维皮肤生物学和疾病建模 皮肤培养物、器官型皮肤培养物和人类皮肤异种移植物;以及3）促进使用良好的 通过建立Penn Dermatology BioBank注释皮肤生物标本，其中包括正常和 患病的人类皮肤样本，有或没有配对的血液样本，包括相关的临床和遗传数据。

PROJECT SUMMARY The Skin Translational Research (STaR) Core aims to foster innovative and pathophysiologically relevant skin biology and disease research by facilitating experiments using human primary samples. Fresh human skin and primary skin cells are highly valuable resources that help to extend skin research throughout the larger scientific community at our institution, evidenced by the large number of investigators outside the Department of Dermatology who have previously used our Core services and subsequently submitted new abstracts, publications, and grant applications on skin biology. By combining highly utilized primary tissue services with innovative tissue engineering, high-throughput screening, and biobanking consultation and services, STaR Core aims to maximize our impact within an even broader scientific community. Our long-term objectives are to: (1) allow investigators both within and outside the Department of Dermatology to conduct research on skin biology more efficiently and effectively by centralizing high-volume or specialized technical services and providing the critical research infrastructure and institutional review board approvals for their use; (2) foster innovative exploratory projects and junior investigators in skin biology through our core services, with the goal of promoting new scientific collaborations, abstracts, manuscripts, and grants; (3) promote translational research by providing access to normal and diseased human skin samples that might not otherwise be available to non-physicians or have substantial administrative barriers to their use; and (4) integrate our core directors’ research expertise into future core services to adapt to the emerging needs and opportunities of our membership. To accomplish these goals we aim to: 1) Accelerate novel pathway discovery through both targeted investigations of candidate pathways as well as unbiased high-throughput screening assays in primary human skin cells; 2) Enable 3-dimensional skin biology and disease modeling through ex vivo human skin cultures, organotypic skin cultures, and human skin xenografts; and 3) Promote research using well- annotated skin biospecimens by establishing the Penn Dermatology BioBank, which includes both normal and diseased human skin samples, with or without paired blood samples, including linked clinical and genetic data.