P30 Center Core Grant for Vision Research

P30 中心视觉研究核心资助

• 批准号: 10477424
• 负责人: MICHAEL H ELLIOTT
• 金额: $ 14.51万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10477424
• 关键词: 3-Dimensional; Center Core Grants; Collaborations; Computer software; Core Facility; Equipment; Eye; Fostering; Functional disorder; Funding; Grant; Guidelines; Health Sciences; Histologic; Histology; Hour; Image; Label; Laboratories; Laboratory Research; Lasers; Microtome - medical device; Oklahoma; Paraffin; Physiology; Postdoctoral Fellow; Principal Investigator; Productivity; Publications; Research; Research Personnel; Resolution; Resources; Scanning; Sepharose; Services; Slide; Stains; Tissues; Training; Training and Infrastructure; Universities; Vision; Vision research; cellular imaging; confocal imaging; cryostat; digital imaging; imaging modality; imaging system; innovation; microscopic imaging; programs; ranpirnase; student training

ABSTRACT Cellular Imaging Core A crucial focus of vision research laboratories at the University of Oklahoma Health Sciences Center is understanding ocular tissue physiology and pathophysiology at the cellular level. Every vision research laboratory on our campus requires the infrastructure and training necessary to label, image, and quantitatively analyze tissues at the cellular and subcellular levels. Furthermore, the competitiveness of our researchers requires that they incorporate new imaging modalities, analytical approaches, and hardware into their research programs. Training on and access to state-of-the-art cellular imaging modalities is expensive and necessitates shared core facilities to foster innovative new research approaches and collaborations, to sustain high productivity, and remain at the forefront of the field. The Cellular Imaging and Morphometric Analysis Core (CIC) currently supports vision research on 16 NEI-funded R01 grants, providing highly knowledgeable expert support along with the bright field, epifluorescence, stereomicroscopes and laser scanning confocal microscopes for image capture at the macro and micro levels. The highly sophisticated software packages provided by the CIC (Metamorph and Imaris) enable vision researchers to render and analyze images. The core provides access and high quality training for students, postdoctoral fellows, staff, and principal investigators on the use of CIC equipment and resources to greatly expand their investigative capabilities, develop creative new ideas, and promote collaborative interactions.

摘要 细胞成像核心 俄克拉荷马大学健康科学中心视觉研究实验室的一个关键焦点是 在细胞水平上了解眼组织生理学和病理生理学。所有视觉研究 我们园区的实验室需要必要的基础设施和培训来标记、成像和量化 在细胞和亚细胞水平上分析组织。此外，我们研究人员的竞争力 要求他们将新的成像模式、分析方法和硬件纳入他们的研究 程序。培训和使用最先进的细胞成像模式是昂贵的，而且有必要 共享核心设施，以促进创新的新研究方法和合作，以保持高水平 生产力，并保持在该领域的领先地位。细胞成像和形态分析核心 (CIC)目前支持NEI资助的16项R01资助的视觉研究，提供知识渊博的专家 支持亮场、荧光、体视显微镜和激光扫描共聚焦 用于在宏观和微观层面捕捉图像的显微镜。高度复杂的软件包 由CIC(Metamorph和Imaris)提供，使视觉研究人员能够渲染和分析图像。这个 CORE为学生、博士后研究员、教职员工和校长提供途径和高质量的培训 侦查员利用中情局的设备和资源，大大扩展了侦查能力， 开发创造性的新想法，促进协作互动。