Magnetic resonance biomarkers of muscle degeneration in patients with rotator cuff tears

肩袖撕裂患者肌肉退化的磁共振生物标志物

• 批准号: 10478830
• 负责人: Sean C Forbes
• 金额: $ 19.93万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10478830
• 关键词: Accounting; Age; Aging; American; Biological; Biological Markers; Biopsy; Blood Vessels; Caring; Clinical; Clinical Research; Custom; Data; Disease Progression; Engineering; Fatty acid glycerol esters; Florida; Foundations; Future; Gait; Gold; Grant; Health; Histologic; Image; Impairment; Individual; Lower Extremity; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measures; Metabolic; Methods; Muscle; Muscle Contraction; Muscle function; Myopathy; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Natural regeneration; Outcome; Outcome Measure; Pain; Pain management; Pathologic; Pathologic Processes; Patient-Focused Outcomes; Patients; Performance; Perfusion; Phosphocreatine; Play; Process; Protocols documentation; Research; Role; Rotator Cuff; Sampling; Scanning; Shoulder; Shoulder Pain; Skeletal Muscle; Standardization; Strategic Planning; Symptoms; Tendon structure; Testing; Thick; Time; Tissue Sample; Tissues; Treatment Efficacy; Universities; base; blood oxygen level dependent; clinical application; high reward; high risk; histological studies; improved; innovation; loss of function; muscle degeneration; novel; quantitative imaging; recruit; response; rotator cuff tear; sex; skeletal disorder; spectroscopic imaging; success; supraspinatus muscle; therapeutic target; tool

PROJECT ABSTRACT Histological studies showed that the degenerative process following rotator cuff tears goes beyond the mere accumulation of fat and includes diminished functional contractile tissue and altered perfusion. Histological measures are limited in clinical studies due to the invasive methods (biopsy) necessary to sample tissue. Quantitative magnetic resonance (MR) imaging and spectroscopy can measure the degenerative process in skeletal muscles, track disease progression and therapeutic efficacy. MR imaging-based Blood Oxygen Level- Dependent (MRI-BOLD) and 31phosphorus MR spectroscopy (31P-MRS) are reliable estimates of muscle microvascular function and energetic status, which are makers of muscle function and quality. Alterations of MRI- BOLD and 31P-MRS are related to lower extremity weakness and decreased gait performance associated with aging, as well as the degeneration associated with pathological disorders of skeletal muscles. Thus, MRI-BOLD and 31P-MRS offer advantages over measures of muscle function and quality that require tissue sampling. These markers may enhance the mechanistic understanding of the degenerative process following rotator cuff tendon tears, and may provide quantitative measures for treatment efficacy, which is of the utmost importance considering the recent advent of biological augmented treatment approaches. Ultimately, they can positively impact the care of over 4.5 million Americans who seek treatment for rotator cuff tears each year. This project will use MR-derived markers (MRI-BOLD, 31P-MRS) to investigate microvascular function and energetic status of the supraspinatus in 30 individuals with full-thickness supraspinatus tears, the most commonly torn rotator cuff tendon. Thirty age and sex-matched individuals without shoulder pain or imaging evidence of rotator cuff tears will be recruited as controls. This project has three specific aims: 1) Develop a dynamometer to measure shoulder abduction force in real-time during MR scans; 2) Test the hypothesis that post-contractile MRI-BOLD response and energetic status evaluated with 31P-MRS of the supraspinatus differ between patients with full- thickness supraspinatus tendon tears versus control individuals; and 3) Test the hypothesis that the MRI-BOLD response and energetic status of the supraspinatus predict shoulder function and abduction strength in patients with full-thickness supraspinatus tendon tears, after accounting for the variance predicted by sex, pain, and fat accumulation. Completing this study will advance the field of quantitative imaging by providing non-invasive measures of muscle vascularity and energetic status in individuals with full-thickness supraspinatus tendon tears. These measures will advance the understanding of the degenerative mechanisms after rotator cuff tendon tears. Future clinical research will evaluate the impact of supraspinatus degeneration/regeneration on patients’ symptoms and the efficacy of promising treatment approaches. Ultimately, this innovative proposal will lay the foundation to promote a paradigm shift in the way we approach and treat rotator cuff tears.

项目摘要 组织学研究表明，肩袖撕裂后的退行性过程不仅仅是 脂肪堆积，包括功能性收缩组织减少和灌注改变。组织学 由于组织取样需要侵入性方法（活检），临床研究中的措施受到限制。 定量磁共振 (MR) 成像和光谱学可以测量退化过程 骨骼肌，跟踪疾病进展和治疗效果。基于 MR 成像的血氧水平 - 依赖性 (MRI-BOLD) 和 31 磷 MR 波谱 (31P-MRS) 是肌肉的可靠估计 微血管功能和能量状态是肌肉功能和质量的决定因素。 MRI 的改变 BOLD 和 31P-MRS 与下肢无力和步态表现下降有关 衰老以及与骨骼肌病理性疾病相关的退化。因此，MRI-BOLD 31P-MRS 比需要组织取样的肌肉功能和质量测量具有优势。这些 标记物可以增强对肩袖肌腱退变过程的机制理解 眼泪，并可以提供治疗效果的定量测量，这是最重要的 考虑到最近出现的生物增强治疗方法。最终，他们可以积极地 每年影响超过 450 万因肩袖撕裂寻求治疗的美国人的护理。这个项目 将使用 MR 衍生标记（MRI-BOLD、31P-MRS）来研究微血管功能和能量状态 30 名患有全层冈上肌撕裂（最常见的旋转肌撕裂）的人的冈上肌 袖口肌腱。三十岁且性别匹配的个体，无肩部疼痛或肩袖影像学证据 将招募眼泪作为对照。该项目有三个具体目标：1）开发测功机来测量 MR 扫描期间实时肩部外展力； 2) 检验收缩后 MRI-BOLD 的假设 用 31P-MRS 评估的冈上肌反应和能量状态在完全不同的患者之间存在差异。 与对照个体相比，冈上肌腱撕裂的厚度； 3) 检验 MRI-BOLD 的假设 冈上肌的反应和能量状态可预测患者的肩部功能和外展力量 在考虑了性别、疼痛和脂肪预测的方差后，冈上肌腱全层撕裂 积累。完成这项研究将通过提供非侵入性的方法来推进定量成像领域的发展 测量冈上肌腱全层撕裂患者的肌肉血管分布和能量状态。 这些措施将增进对肩袖肌腱撕裂后退行性机制的理解。 未来的临床研究将评估冈上肌变性/再生对患者的影响 症状和有希望的治疗方法的功效。最终，这一创新提案将奠定 基金会旨在促进我们处理和治疗肩袖撕裂的方式发生范式转变。

项目成果

Preseason lower extremity range of motion, flexibility, and strength in relation to in-season injuries in NCAA division I gymnasts.

NCAA一级体操运动员季前赛下肢的运动范围、灵活性和力量与赛季中受伤的关系。

• DOI: 10.1080/00913847.2023.2215775
• 发表时间: 2024
• 期刊: The Physician and sportsmedicine
• 作者: Bates,Kaysha;Zeppieri,Giorgio;Young,Candace;Bruner,Michelle;Moser,Michael;Farmer,KevinW;Pozzi,Federico
• 通讯作者: Pozzi,Federico

Olympic Weightlifting Training for Sprint Performance in Athletes: A Systematic Review with Meta-analysis.

奥运会举重训练对运动员冲刺表现的影响：系统评价与荟萃分析。

• DOI: 10.1055/a-2161-4867
• 发表时间: 2024
• 期刊: International journal of sports medicine
• 影响因子: 2.5
• 作者: Crenshaw,Kristen;Zeppieri,Giorgio;Hung,Cheng-Ju;Schmitfranz,Tania;McCall,Patti;Castellini,Greta;Gianola,Silvia;Pozzi,Federico
• 通讯作者: Pozzi,Federico