Developing a diabetes self-management mHealth simulation platform for youth

开发青少年糖尿病自我管理移动医疗模拟平台

基本信息

批准号：
10478215
负责人：
Eileen R. Faulds
金额：
$ 13.36万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-31 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10478215
关键词：
18 year old Adolescence Adolescent Adult Award Behavior Biological Factors Bolus Infusion Carbohydrates Child Chronic Disease Clinical Trials Complex Data Data Analytics Data Set Development Devices Diabetes Mellitus Disease Educational workshop Endocrinology Engineering Environment Environmental Risk Factor Event Exhibits Fostering Frequencies Future Glucose Glycosylated Hemoglobin Glycosylated hemoglobin A Goals Guidelines Health Hybrids Hyperglycemia Hypoglycemia Individual Injections Insulin Insulin Infusion Systems Insulin-Dependent Diabetes Mellitus Intervention Interview K-Series Research Career Programs Knowledge Laboratories Measures Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Methods Microvascular Dysfunction Mission Modeling Online Systems Outcome Pattern Physiological Pilot Projects Positioning Attribute Public Health Reaction Time Research Research Personnel Research Project Grants Research Support Research Training Science Scientist Self Management Suspensions Symptoms System Team Nursing Techniques Technology Testing Time Training United States Variant Vulnerable Populations Youth blood glucose regulation career career development design diabetes education diabetes management diabetes self-management experience feasibility testing field study glucose monitor glycemic control hands on research improved improved outcome large datasets mHealth mHealth self-management macrovascular disease novel patient oriented preadolescence prevent promoter recruit response secondary analysis sensor simulation skills symposium technology development therapy development trend usability

项目摘要

PROJECT SUMMARY For the 1.5 million individuals in the United States living with type 1 diabetes (T1D) the importance of maintaining near normal glycemic control, typically measured by glycosylated hemoglobin (A1c), to prevent microvascular and macrovascular complications is well established. Despite recent advancements and increased use of technologies to manage diabetes (i.e., insulin pump, continuous glucose monitoring (CGM), Hybrid Closed Loop (HCL) systems), 70% of individuals with type 1 diabetes (T1D) do not meet their A1c targets. Adolescents fare worse than children and adults with only 17% currently achieving targets. Insulin pump therapy is a more physiologic form of insulin delivery than multiple daily injections, yet these complex machines rely heavily on individual utilization and self-management behaviors. In this Mentored Patient-Oriented Research Career Development Award (K23) we propose three distinct but complementary studies. First, we will examine novel aspects of pre-teen and adolescent diabetes device self-management by conducting a secondary analysis of a large dataset that combines diabetes device self-management, utilization and glucose data from the youth’s diabetes device (e.g. insulin pump, CGM, HCL). Second, we will extend the functionality and test the validity of an existing mHealth diabetes education simulation platform (A1Control) among youth (10-18 years of age) with T1D using participatory design techniques including co-design workshops, and laboratory usability testing. Third, we will conduct a pilot study to assess the feasibility, sustained engagement and impact of the mHealth intervention among youth (10-18 years of age) with T1D. This proposed training award is congruent with NINR’s mission to support research that models or improves understanding of self-management behaviors as well as cross-cutting alignment in advancing data analytics for technology to improve health. Career development objectives are: (1) developing advanced device and sensor data analytics skills; (2) enhancing knowledge and skills of participatory design methods; and, (3) acquiring skills in clinical trials intervention development and testing. Career objectives will be accomplished through a combination of formal didactic and informal trainings; participation in national conferences and workshops; and hands-on research training under the mentorship of an accomplished team of scientists in the field of patient centered technology development (Mion and Happ), data analytics and secondary analysis (Shoben and Mion), and clinical trials research (Mion, Dungan, Happ and Shoben). The candidate’s mentors and collaborators comprise a transdisciplinary team from nursing, endocrinology, engineering, and public health. The skills, experience, and training gained from this career development award will position the candidate for a successful career as an independent investigator focused on the science of chronic disease self-management and technology utilization with development and organization of future large scale trials aimed at fostering improved outcomes for individuals with diabetes.

项目摘要对于美国150万人患有1型糖尿病（T1D）维护的重要性通常通过糖基化血红蛋白（A1C）测量的几乎正常血糖控制，以防止微血管大血管并发症已经确定。尽管最近进步并增加了管理糖尿病的技术（即胰岛素泵，连续葡萄糖监测（CGM），混合闭环（HCL）系统），有70％的1型糖尿病患者（T1D）不符合其A1C靶标。青少年远比目前只有17％实现目标的儿童和成人还要糟糕。胰岛素泵治疗更多胰岛素输送的生理形式比多次注射的生理形式，但是这些复杂的机器很大程度上依赖个人利用和自我管理行为。在这项受到指导的以患者为导向的研究职业中开发奖（K23）我们提出了三个不同但完整的研究。首先，我们将研究小说青少年和青少年糖尿病设备自我管理的各个方面通过对大型数据集结合了糖尿病设备的自我管理，利用和葡萄糖数据糖尿病装置（例如胰岛素泵，CGM，HCL）。其次，我们将扩展功能并测试现有的MHealth糖尿病教育模拟平台（A1 Control）（10-18岁）与 T1D使用参与设计技术，包括共同设计研讨会和实验室可用性测试。第三，我们将进行一项试点研究，以评估MHealth的可行性，持续参与和影响 T1D的青年（10-18岁）之间的干预。该拟议的培训奖与Ninr的培训奖是一致的支持研究或改善对自我管理行为以及在推进技术分析以改善健康的数据分析方面的跨剪切一致性。职业发展目标是：（1）开发高级设备和传感器数据分析技能；（2）增强知识和参与设计方法的技能；（3）在临床试验干预开发和测试。职业对象将通过正式的教学和非正式培训来实现；参加民族会议和研讨会；以及在心态下的动手研究培训在以患者为中心的技术开发领域（Mion和Happ）领域的科学家团队，数据分析和二级分析（Shoben和Mion）以及临床试验研究（Mion，Dungan，Happ和 Shoben）。候选人的导师和合作者组成了护士的跨学科团队，内分泌，工程和公共卫生。从这个职业中获得的技能，经验和培训开发奖将使候选人成为成功的职业生涯的候选人关于随着发展的慢性疾病自我管理和技术利用的科学旨在促进糖尿病患者改善结果的未来大规模试验的组织。