Enhancing Recovery Outcomes in Alcohol Use Disorder: Cognitive Training as an Adjunct to Treatment

提高酒精使用障碍的康复效果：认知训练作为治疗的辅助手段

• 批准号: 10244993
• 负责人: Ben Lewis
• 金额: $ 14.83万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-20 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10244993
• 关键词: Abstinence; Address; Alcohol consumption; Alcoholism; Alcohols; Attention deficit hyperactivity disorder; Basic Science; Biometry; Clinical Research; Cognitive; Computers; Consumption; Control Groups; Data; Data Collection; Development; Distal; Education; Educational Intervention; Effectiveness; Evaluation; Future; Health; Human Resources; Impaired cognition; Impairment; Individual; Individual Differences; Inpatients; Intervention; Intervention Studies; Interview; Investigation; Knowledge; Literature; Measures; Mentored Research Scientist Development Award; Mentors; Methods; Modeling; Modification; Motivation; Neurocognitive; Neurocognitive Deficit; Outcome; Participant; Performance; Predictive Factor; Procedures; Process; Public Health; Recovery; Recovery of Function; Research; Research Training; Response to stimulus physiology; Sampling; Science; Self Efficacy; Severities; Short-Term Memory; Training; Training Support; Treatment Efficacy; Treatment outcome; Work; active control; addiction; alcohol abuse therapy; alcohol craving; alcohol intervention; alcohol use disorder; base; career; cognitive function; cognitive neuroscience; cognitive recovery; cognitive training; computer human interaction; computer science; computer studies; computerized; craving; drinking; executive function; follow-up; functional improvement; functional outcomes; improved; longitudinal analysis; model development; multidisciplinary; novel; programs; recruit; remediation; response; screening; sex; skills; substance use; theories; treatment arm; treatment as usual; treatment duration

Project Summary/Abstract Programmatic investigation of neurocognitive functioning in alcohol use disorder (AUD) has revealed widespread and sustained impairments. Despite conceptual relevance to treatment efficacy, few AUD interventions have been directed to the remediation of these impairments. The proposed K01 is responsive to this gap. It will answer critical questions regarding the potential of cognitive training (CT), applied as an adjunct to inpatient treatment, to improve cognitive recovery and post-discharge functional outcomes in AUD. The PI, Dr. Lewis, is an early career cognitive neuroscientist, committed to alcohol science and the development of novel interventions for AUD. His basic science background was directed toward facilitating abstinence in individuals with AUDs. His clinical research has focused on the investigation of alcohol-associated neurocognitive perturbations. The proposed K01 will facilitate his integration of these aims into the development of a research program directed toward novel interventions promoting neurocognitive and functional recovery. The proposed research and training benefit from a diverse, multidisciplinary mentoring team, leveraging expertise in cognitive neuroscience, addiction, cognitive training, computer science, and biostatistical analysis. The training supported by this K01 award will include the development of expertise in advanced methods/analysis of longitudinal health interventions, and the development of knowledge and skill bases in human-computer interaction theory, facilitating Dr. Lewis’ ability to develop individualized, adaptive computer- based interventions. The current project will investigate the efficacy of two experimental cognitive training interventions in a sample of inpatients in treatment for AUD. While the effectiveness of CT to enhance function is supported by diverse literatures, it remains largely unexamined in AUD. The current proposal will question the degree to which cognitive training interventions can “transfer” cognitive gains to untrained tasks/domains, and improve overall executive functioning. It will apply conceptual models from the CT and alcohol literatures to identify factors associated with CT efficacy. The impact of cognitive training on functional outcomes, including post-discharge drinking, will be investigated. Finally, relationships between cognitive recovery during treatment and post- discharge adaptation will be interrogated. Thus, the proposed work will be of substantial import to public health, alcohol science, and will inform future intervention efforts.

项目总结/摘要 对酒精使用障碍（AUD）的神经认知功能的程序性研究显示， 广泛和持续的损害。尽管概念上与治疗疗效相关，但很少有AUD 干预措施的目的是纠正这些缺陷。建议的K 01响应于 这个差距。它将回答有关认知训练（CT）的潜力的关键问题，作为一种辅助手段 住院治疗，以改善认知恢复和出院后功能的结果在AUD。 PI，刘易斯博士，是一个早期的职业认知神经科学家，致力于酒精科学和 开发针对AUD的新型干预措施。他的基础科学背景是为了促进 在AUD患者中禁欲。他的临床研究主要集中在酒精相关的 神经认知紊乱拟议的K 01将促进他将这些目标融入发展中， 一项旨在促进神经认知和功能恢复的新干预措施的研究计划。 拟议的研究和培训受益于一个多样化的多学科指导团队， 认知神经科学、成瘾、认知训练、计算机科学和生物统计分析方面的专业知识。 K 01奖项支持的培训将包括高级专业知识的发展 方法/纵向健康干预措施的分析，以及知识和技能基础的发展， 人机交互理论，促进刘易斯博士开发个性化，自适应计算机的能力， 基于干预。 目前的项目将在一个样本中调查两种实验性认知训练干预的有效性 接受AUD治疗的住院患者。虽然CT增强功能的有效性得到了多种因素的支持， 文献中，它仍然在很大程度上未经审查的澳元。目前的提案将质疑 认知训练干预可以将认知收益“转移”到未经训练的任务/领域， 执行功能它将应用CT和酒精文献中的概念模型来识别因素 与CT疗效相关。认知训练对功能结果的影响，包括出院后 饮酒，将被调查。最后，研究了治疗期间认知恢复与治疗后认知恢复之间的关系。 将询问放电适应。因此，拟议的工作将对公共卫生具有重大意义， 酒精科学，并将为未来的干预工作提供信息。