Biostatistics and Bioinformatics Core

生物统计学和生物信息学核心

• 批准号: 10478813
• 负责人: Masha Kocherginsky
• 金额: $ 16.45万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-18 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10478813
• 关键词: Address; Adherence; Affinity; Binding; Bioinformatics; Biological; Biometry; Cell physiology; Cells; ChIP-seq; Chicago; Clinical; Clinical Data; Clinical Trials; Code; Collaborations; Complement; Comprehensive Cancer Center; Computer Systems; Computer software; Consultations; Custom; Data; Data Analyses; Data Analytics; Data Science; Data Set; Databases; Development; Dose; Ensure; Environment; Evaluation; Experimental Designs; Faculty; Fostering; Funding; Gene set enrichment analysis; Genes; High Performance Computing; High-Throughput Nucleotide Sequencing; Individual; Investigation; Link; Maintenance; Malignant neoplasm of prostate; Modification; Molecular; Monitor; Monitoring Clinical Trials; Ontology; Output; Pathway interactions; Patients; Phase I Clinical Trials; Prostate; Protocols documentation; Registries; Reporting; Reproducibility; Research; Research Design; Research Personnel; Safety; Secure; Site; Statistical Data Interpretation; Techniques; Time; Tissue Sample; Tissues; Universities; Visualization; base; bioinformatics pipeline; clinical database; clinical trial participant; cohort; data management; data registry; data resource; data standards; differential expression; experimental study; genetic manipulation; genome browser; high dimensionality; improved; innovation; medical schools; member; pre-clinical; preclinical study; programs; reference genome; repository; single-cell RNA sequencing; synergism; transcriptome sequencing

CORE B: ABSTRACT The Biostatistics and Bioinformatics Core (Core B) is a central component of the Prostate SPORE, providing state-of-the-art integrated data science support to all Prostate SPORE projects. Database development and maintenance will provide a centralized resource for data tracking for preclinical studies, ensuring efficient reporting and statistical analysis of all experiments. In addition, clinical databases will be enhanced and developed in conjunction with all project teams to complement existing clinical trial data registries at Northwestern and ensure custom data capture in a highly secure environment. Bioinformatics activities of Core B are central to discovery and will help define new and significant research directions. The large omics data sets that will be generated in the Prostate SPORE Projects require specialized expertise for preprocessing, analysis and interpretation of molecular and biological consequences of genetic manipulations and treatments. Bioinformatics functionality provided by Core B will provide this crucial assistance for all proposed Prostate SPORE Projects. Biostatistical activities of Core B are central to the concerns of rigor and reproducibility: by providing study design guidance, data management, statistical analysis and consultation for interpretation of results the core will see that reported results have been rigorously controlled and will be reproducible by others. All functions of the Core B will be conducted in association with the following Specific Aims: AIM 1: Maintain and enhance the pre-clinical, clinical and tissue databases of the Prostate SPORE; AIM 2: Provide state-of-the-art bioinformatics expertise to the Prostate SPORE projects; AIM 3: Provide experimental design guidance and biostatistics collaboration and analysis support for all preclinical studies and clinical trials Through these activities Core B will serve as a key contributor to all individual projects and will ensure that project output is accurate, reliable, and of the highest quality.

核心B：摘要 生物统计学和生物信息学核心（核心B）是前列腺孢子的核心组成部分，提供 为所有Prostate SPORE项目提供最先进的集成数据科学支持。数据库开发和 维护将为临床前研究的数据跟踪提供集中资源， 所有实验的报告和统计分析。此外，将加强临床数据库， 与所有项目团队共同开发，以补充现有的临床试验数据登记， 西北和确保定制数据捕获在一个高度安全的环境。核心生物信息学活动 B是发现的核心，将有助于确定新的和重要的研究方向。大组学数据 将在前列腺孢子项目中生成的集合需要用于预处理的专门知识， 分析和解释遗传操作和治疗的分子和生物学后果。 核心B提供的生物信息学功能将为所有拟议的前列腺 SPORE项目。核心B的生物统计学活动对于严谨性和重现性至关重要： 提供研究设计指导、数据管理、统计分析和咨询，以解释 结果核心将看到报告的结果已被严格控制，并将被其他人重现。 核心B的所有职能将与以下具体目标相关联：目标1：维护和 增强前列腺孢子的临床前、临床和组织数据库; AIM 2：提供最先进的 前列腺孢子项目的生物信息学专业知识;目的3：提供实验设计指导， 为所有临床前研究和临床试验提供生物统计学协作和分析支持 核心B将作为所有个别项目的主要贡献者，并将确保项目产出准确， 可靠，质量最高。