Quantitative Data Sciences Core Facility Shared Resource

定量数据科学核心设施共享资源

• 批准号: 10902187
• 负责人: Masha Kocherginsky
• 金额: $ 50.74万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10902187
• 关键词: ATAC-seq; Advanced Malignant Neoplasm; Applications Grants; Area; Basic Science; Bioinformatics; Biometry; Biostatistics Core; Biotechnology; Cancer Center; Cancer Center Support Grant; Cancer health equity; ChIP-seq; Chicago; Clinical; Clinical Cancer Center; Clinical Informatics; Clinical Sciences; Clinical Trials; Complex; Comprehensive Cancer Center; Computerized Medical Record; Core Facility; Custom; Data; Data Analyses; Data Science; Data Science Core; Databases; Development; Dimensions; Discipline; Disease; Doctor of Philosophy; Faculty; Gene Expression; Genes; Genetic; Goals; Image; Informatics; Information Retrieval; Information Systems; Journals; Laboratories; Machine Learning; Maintenance; Malignant Neoplasms; Malignant neoplasm of prostate; Measurement; Medicine; Methylation; Microarray Analysis; Monitor; Natural Language Processing; Outcome; Paper; Pathology; Pathway interactions; Phase; Physiological; Population Sciences; Publications; Reporting; Research; Research Design; Research Personnel; Resource Sharing; Secure; Services; Statistical Data Interpretation; Statistical Methods; Surveys; System; Variant; Work; cancer clinical trial; data management; data repository; data submission; data visualization; data warehouse; design; electronic data; informatics infrastructure; informatics tool; member; next generation sequencing; oncology trial; personalized medicine; preclinical study; programs; protocol development; public database; randomized, clinical trials; statistics; success; tool; transcriptome; variant detection; web platform

ABSTRACT – QUANTITATIVE DATA SCIENCES CORE The Quantitative Data Sciences Core (QDSC) provides a state-of-the-art integrated approach for Data Science support to Lurie Cancer Center (LCC) members in the basic, clinical and population sciences. ‘Data Sciences’ includes the three disciplines of Biostatistics, Bioinformatics and Clinical Informatics. Since the last CCSG review, the former Biostatistics Core and Cancer Informatics Core have been integrated into a new QDSC to provide a unified approach to data definition, acquisition, management, analysis and reporting. The QDSC Director is Alfred Rademaker PhD; Associate Directors are Denise Scholtens PhD (Biostatistics), Matthew Schipma PhD (Bioinformatics) and Firas Wehbe MD,PhD (Clinical Informatics). As part of this consolidation, the core has been expanded through the addition of faculty and staff effort bridging the fields of informatics and statistics, areas of expertise often sought together by members of the LCC. The QDSC also works collaboratively with the Pathology Core Facility, the Outcomes Measurement and Survey Core, and the LCC Clinical Trials Office. The Biostatistics component provides power calculations and statistical analyses to investigators who are planning and conducting basic and preclinical studies and assists in the development of early phase and randomized clinical trials. The Bioinformatics component provides support for the analysis of next generation sequencing data, pathway identification, variant detection, methylation analysis, and data visualization. The Clinical Informatics component provides clinical trial management, disease-based database and informatics tools, project specific Research Electronic Data Capture (REDCap) development, pathology data management, and support for accessing and analyzing Northwestern Medicine Electronic Data Warehouse (NMEDW) data. QDSC Clinical Informatics has integrated and augmented the Northwestern Oncology Trial Information System (NOTIS), LCC’s clinical trial management system, and the electronic medical record (Epic) used by our clinical partners. QDSC has been heavily used by cancer researchers, with 109 LCC members using the Core in the last year, and it has been instrumental in the publication of 151 papers, many in high impact journals. Moreover, it has contributed to the success of many grant applications, notable among them a renewal of a SPORE in Prostate Cancer and a new U54 Chicago Collaborative to Promote and Advance Cancer Health Equity.

摘要--定量数据科学核心 定量数据科学核心(QDSC)为数据科学提供了一种最先进的集成方法 在基础、临床和人口科学方面为Lurie癌症中心(LCC)成员提供支持。“数据科学” 包括生物统计学、生物信息学和临床信息学三个学科。自上次CCSG以来 回顾，原生物统计学核心和癌症信息学核心已整合到新的QDSC中，以 提供统一的数据定义、获取、管理、分析和报告方法。QDSC 主任是Alfred Rademaker博士；副主任是Denise Scholten博士(生物统计学)，Matthew Schipma博士(生物信息学)和Firas Wehbe医学博士(临床信息学)。作为这一整合的一部分， 核心已经通过增加教职员工的努力来扩大，架起了信息学和 统计，这是LCC成员经常共同寻求的专业领域。QDSC也协同工作 拥有病理学核心设施、结果测量和调查核心，以及LCC临床试验 办公室。 生物统计组件为符合以下条件的调查人员提供电力计算和统计分析 计划和进行基础和临床前研究，并协助开发早期和 随机临床试验。生物信息学组件为下一代的分析提供支持 测序数据、路径识别、变异检测、甲基化分析和数据可视化。这个 临床信息学部分提供临床试验管理、基于疾病的数据库和信息学 工具、项目特定研究电子数据捕获(RedCap)开发、病理数据管理、 以及对访问和分析西北医学电子数据仓库(NMEDW)数据的支持。 QDSC临床信息学公司整合和增强了西北肿瘤试验信息系统 LCC的临床试验管理系统(NOTIS)和我们临床使用的电子病历(EPIC) 合伙人。 癌症研究人员大量使用QDSC，去年有109名LCC成员使用该核心， 它在151篇论文的发表中发挥了重要作用，其中许多论文发表在影响力很大的期刊上。此外，它还拥有 为许多赠款申请的成功做出了贡献，其中值得注意的是前列腺癌的一个孢子的续展 癌症和新的U54芝加哥合作促进和推进癌症健康公平。