Biostatistics and Bioinformatics Core

生物统计学和生物信息学核心

• 批准号: 10089061
• 负责人: Masha Kocherginsky
• 金额: $ 14.33万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-18 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10089061
• 关键词: Address; Adherence; Affinity; Binding; Bioinformatics; Biological; Biometry; Cell physiology; Cells; ChIP-seq; Chicago; Clinical; Clinical Data; Clinical Trials; Code; Collaborations; Complement; Comprehensive Cancer Center; Computer Systems; Computer software; Consultations; Custom; Data; Data Analyses; Data Analytics; Data Science; Data Set; Databases; Development; Dose; Ensure; Environment; Evaluation; Experimental Designs; Faculty; Fostering; Funding; Gene set enrichment analysis; Genes; High Performance Computing; High-Throughput Nucleotide Sequencing; Individual; Investigation; Link; Maintenance; Malignant neoplasm of prostate; Modification; Molecular; Monitor; Monitoring Clinical Trials; Ontology; Output; Pathway interactions; Patients; Phase I Clinical Trials; Prostate; Protocols documentation; Registries; Reporting; Reproducibility; Research; Research Design; Research Personnel; Safety; Secure; Site; Statistical Data Interpretation; Techniques; Time; Tissue Sample; Tissues; Universities; Visualization; base; bioinformatics pipeline; clinical database; clinical trial participant; cohort; data management; data registry; data resource; data standards; differential expression; experimental study; genetic manipulation; genome browser; high dimensionality; improved; innovation; medical schools; member; pre-clinical; preclinical study; programs; reference genome; repository; single-cell RNA sequencing; synergism; transcriptome sequencing

CORE B: ABSTRACT The Biostatistics and Bioinformatics Core (Core B) is a central component of the Prostate SPORE, providing state-of-the-art integrated data science support to all Prostate SPORE projects. Database development and maintenance will provide a centralized resource for data tracking for preclinical studies, ensuring efficient reporting and statistical analysis of all experiments. In addition, clinical databases will be enhanced and developed in conjunction with all project teams to complement existing clinical trial data registries at Northwestern and ensure custom data capture in a highly secure environment. Bioinformatics activities of Core B are central to discovery and will help define new and significant research directions. The large omics data sets that will be generated in the Prostate SPORE Projects require specialized expertise for preprocessing, analysis and interpretation of molecular and biological consequences of genetic manipulations and treatments. Bioinformatics functionality provided by Core B will provide this crucial assistance for all proposed Prostate SPORE Projects. Biostatistical activities of Core B are central to the concerns of rigor and reproducibility: by providing study design guidance, data management, statistical analysis and consultation for interpretation of results the core will see that reported results have been rigorously controlled and will be reproducible by others. All functions of the Core B will be conducted in association with the following Specific Aims: AIM 1: Maintain and enhance the pre-clinical, clinical and tissue databases of the Prostate SPORE; AIM 2: Provide state-of-the-art bioinformatics expertise to the Prostate SPORE projects; AIM 3: Provide experimental design guidance and biostatistics collaboration and analysis support for all preclinical studies and clinical trials Through these activities Core B will serve as a key contributor to all individual projects and will ensure that project output is accurate, reliable, and of the highest quality.

核心B：摘要 生物统计和生物信息学核心(核心B)是前列腺孢子的中心组成部分，提供 为所有前列腺癌孢子项目提供最先进的综合数据科学支持。数据库开发和 维护将为临床前研究提供集中的数据跟踪资源，确保高效 所有实验的报告和统计分析。此外，还将加强临床数据库，并 与所有项目团队共同开发，以补充现有的临床试验数据登记，网址为 并确保在高度安全的环境中捕获定制数据。CORE的生物信息学活动 B是发现的核心，将有助于确定新的和重要的研究方向。大型组学数据 将在前列腺癌孢子项目中产生的集合需要专门的前处理专业知识， 分析和解释遗传操作和治疗的分子和生物学后果。 Core B提供的生物信息学功能将为所有建议的前列腺癌提供这一至关重要的帮助 孢子项目。核心B的生物统计活动对严谨性和再现性的关注至关重要： 提供研究设计指导、数据管理、统计分析和咨询 结果核心将看到报告的结果已被严格控制，并将被其他人复制。 核心B的所有职能将结合以下具体目标进行：目标1：维护和 增强前列腺孢子的临床前、临床和组织数据库；目标2：提供最先进的 为前列腺孢子项目提供生物信息学专业知识；目标3：提供实验设计指导和 通过这些活动为所有临床前研究和临床试验提供生物统计协作和分析支持 核心B将作为所有个别项目的关键贡献者，并将确保项目产出准确， 可靠，质量最好。