Quantitative Data Sciences Core Facility Shared Resource

定量数据科学核心设施共享资源

• 批准号: 9762034
• 负责人: Masha Kocherginsky
• 金额: $ 50.47万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9762034
• 关键词: ATAC-seq; Advanced Malignant Neoplasm; Applications Grants; Area; Basic Science; Bioinformatics; Biometry; Biostatistics Core; Biotechnology; Cancer Center; Cancer Center Support Grant; ChIP-seq; Chicago; Clinical; Clinical Cancer Center; Clinical Informatics; Clinical Sciences; Clinical Trials; Complex; Comprehensive Cancer Center; Computerized Medical Record; Core Facility; Custom; Data; Data Analyses; Data Science; Databases; Detection; Development; Discipline; Disease; Doctor of Philosophy; Faculty; Gene Expression; Genes; Genetic; Goals; Informatics; Information Systems; Journals; Laboratories; Machine Learning; Maintenance; Malignant Neoplasms; Malignant neoplasm of prostate; Measurement; Medicine; Methylation; Microarray Analysis; Monitor; Natural Language Processing; Online Systems; Outcome; Paper; Pathology; Pathway interactions; Phase; Physiological; Population Sciences; Publications; Randomized Clinical Trials; Reporting; Research; Research Design; Research Personnel; Resource Sharing; Secure; Services; Statistical Data Interpretation; Statistical Methods; Surveys; System; Systems Development; Variant; Work; base; cancer clinical trial; data management; data submission; data visualization; data warehouse; design; electronic data; health equity; imaging genetics; informatics infrastructure; informatics tool; member; next generation sequencing; oncology trial; personalized medicine; preclinical study; programs; protocol development; statistics; success; tool; transcriptome

ABSTRACT – QUANTITATIVE DATA SCIENCES CORE The Quantitative Data Sciences Core (QDSC) provides a state-of-the-art integrated approach for Data Science support to Lurie Cancer Center (LCC) members in the basic, clinical and population sciences. ‘Data Sciences’ includes the three disciplines of Biostatistics, Bioinformatics and Clinical Informatics. Since the last CCSG review, the former Biostatistics Core and Cancer Informatics Core have been integrated into a new QDSC to provide a unified approach to data definition, acquisition, management, analysis and reporting. The QDSC Director is Alfred Rademaker PhD; Associate Directors are Denise Scholtens PhD (Biostatistics), Matthew Schipma PhD (Bioinformatics) and Firas Wehbe MD,PhD (Clinical Informatics). As part of this consolidation, the core has been expanded through the addition of faculty and staff effort bridging the fields of informatics and statistics, areas of expertise often sought together by members of the LCC. The QDSC also works collaboratively with the Pathology Core Facility, the Outcomes Measurement and Survey Core, and the LCC Clinical Trials Office. The Biostatistics component provides power calculations and statistical analyses to investigators who are planning and conducting basic and preclinical studies and assists in the development of early phase and randomized clinical trials. The Bioinformatics component provides support for the analysis of next generation sequencing data, pathway identification, variant detection, methylation analysis, and data visualization. The Clinical Informatics component provides clinical trial management, disease-based database and informatics tools, project specific Research Electronic Data Capture (REDCap) development, pathology data management, and support for accessing and analyzing Northwestern Medicine Electronic Data Warehouse (NMEDW) data. QDSC Clinical Informatics has integrated and augmented the Northwestern Oncology Trial Information System (NOTIS), LCC’s clinical trial management system, and the electronic medical record (Epic) used by our clinical partners. QDSC has been heavily used by cancer researchers, with 109 LCC members using the Core in the last year, and it has been instrumental in the publication of 151 papers, many in high impact journals. Moreover, it has contributed to the success of many grant applications, notable among them a renewal of a SPORE in Prostate Cancer and a new U54 Chicago Collaborative to Promote and Advance Cancer Health Equity.

摘要-定量数据科学核心 定量数据科学核心（QDSC）为数据科学提供了最先进的集成方法 支持Lurie癌症中心（LCC）成员在基础，临床和人口科学。“数据科学” 包括生物统计学、生物信息学和临床信息学三个学科。自上次CCSG以来 回顾，前生物统计学核心和癌症信息学核心已被整合到一个新的QDSC， 提供统一的数据定义、获取、管理、分析和报告方法。关于QDSC 主任是Alfred Rademaker博士;副主任是Denise Scholtens博士（生物统计学），Matthew Schipma PhD（生物信息学）和Firas Wehbe MD，PhD（临床信息学）。作为整合的一部分， 核心已经扩大了通过增加教师和工作人员的努力，桥接信息学领域， 统计学是LCC成员经常共同寻求的专业领域。QDSC还协同工作 与病理学核心设施，结果测量和调查核心，以及LCC临床试验 办公室 生物统计学组件为研究者提供功效计算和统计分析， 规划和进行基础和临床前研究，并协助开发早期阶段， 随机临床试验。生物信息学组件为分析下一代 测序数据、途径鉴定、变体检测、甲基化分析和数据可视化。的 临床信息学组件提供临床试验管理、基于疾病的数据库和信息学 工具，项目特定的研究电子数据采集（REDCap）开发，病理学数据管理， 并支持访问和分析西北医学电子数据仓库（NMEDW）数据。 QDSC Clinical Informatics整合并增强了西北肿瘤学试验信息系统 （NOTIS）、LCC的临床试验管理系统以及我们的临床试验使用的电子病历（Epic） 伙伴 QDSC已被癌症研究人员大量使用，去年有109名LCC成员使用Core， 它在151篇论文的发表中发挥了重要作用，其中许多论文发表在高影响力的期刊上。此外， 促成了许多赠款申请的成功，其中值得注意的是前列腺的一个SPORE的更新 癌症和一个新的U 54芝加哥合作，以促进和推进癌症健康公平。