BLR&D Research Career Scientist Award Application

BLR

• 批准号: 9338937
• 负责人: Nihal Ahmad
• 金额: --
• 依托单位: WM S. MIDDLETON MEMORIAL VETERANS HOSP
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9338937
• 关键词: Academia; Affect; Afghanistan; Antioxidants; Area; Award; Berry; Biochemical; Biochemistry; Biology; Book Chapters; Cancer Biology; Chemopreventive Agent; Clinical; Collaborations; Country; Deacetylase; Department of Defense; Dermatologic; Dermatology; Development; Dioxins; Event; Extramural Activities; Faculty; Family; Funding; Funding Agency; Goals; Grant; Grapes; Hand; Healthcare; Herbicides; Human; Incidence; Industry; Institutes; International; Investigational Therapies; Iraq; Journals; Laboratories; Lead; Life; Malignant Neoplasms; Malignant neoplasm of prostate; Melatonin; Mentors; Micronutrients; Middle East; Military Personnel; Mission; Mitotic; Molecular; Names; Neoplasms; Nicotinamide adenine dinucleotide; Nuts; Oncogenes; PLK1 gene; Paper; Peer Review; Peer Review Grants; Pharmacology; Photobiology; Photochemistry; Pineal gland; Population; Positioning Attribute; Postdoctoral Fellow; Prevention; Protein Family; Protein-Serine-Threonine Kinases; Publications; Publishing; Radiation; Reporting; Research; Resveratrol; Risk; Role; Scientist; Selenium; Services; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Sirtuins; Skin Cancer; Source; Study Section; Therapeutic; Toxicology; Training; United States National Institutes of Health; Universities; Veterans; Vietnam; Vitamin E; Wisconsin; Work; World War II; anticancer research; base; career; editorial; graduate student; improved; indexing; interest; meetings; melanoma; member; novel strategies; operation; phytoalexins; red wine; symposium; tumor progression; ultraviolet irradiation; undergraduate student

My long-term career goal is to improve the quality of human life, including that of Veterans, through my research. My laboratory focuses on two broad and complimentary research areas: 1) cancer biology and 2) prevention and experimental therapeutics of cancer. My overall goal is to define the critical molecular and biochemical events that occur during cancer development that in turn will assist in identifying targets and new approaches and strategies for cancer management. While interested in cancer in general, my recent focus has been on skin and prostate cancers, both of which disproportionally affect the Veteran population. Examples of ongoing research in my laboratory are as follows. We are studying the role and functional significance of mitotic regulators, including the polo-like kinase (Plk) family of serine/threonine kinases, and how these factors interact with other important cell signaling pathways to influence cancer development and progression. In addition, we are trying to understand the role of nicotinamide adenine dinucleotide (NAD)+ -dependent deacetylases, namely the Sirtuin family proteins, in the development and/or progression of cancer. The second major focus of my research is to define the cancer chemopreventive/therapeutic potential of a variety of agents, such as resveratrol (a phytoalexin antioxidant found in grapes, nuts, berries and red wine), melatonin (the chief secretory product of the pineal gland and a known antioxidant), vitamin E (the major antioxidant in biomembranes) and selenium (an essential micronutrient for humans). My current VA-sponsored research focuses on identifying the mechanism of melanoma development and progression. This research area is extremely relevant to VA healthcare as the U.S. military engages in missions all over the world, including in the Middle East (Iraq and Afghanistan). Deployment to these regions results in significant UV irradiation exposure that increases the risk for malignant melanoma in the Veterans returning from these areas. Based on several studies, an increased incidence of melanoma was reported for World War II Veterans stationed in the Pacific and those exposed to dioxin-contaminated herbicides during Operation Ranch Hand in Vietnam. My ongoing research aims at defining the molecular mechanism of melanoma development. I believe that my research findings are moving towards the identification of novel strategies for the management of this deadly neoplasm. Thus, my work is relevant and significant to Veteran's healthcare and is in line with the mission of the Department of Veterans Affairs. The results of my research are published in a wide range of high-impact scientific journals. I have published more than 170 papers, 150 abstracts and several book chapters (Total Citations: 17,705; h-index, 65; i10-index: 1256 Source: Google Scholar; 8/2016). I serve as an Associate Editor of two well-respected journals, Toxicology and Applied Pharmacology and Photochemistry and Photobiology, and am a member of the Editorial Board of several other journals. I am regularly invited to participate in the peer-review of grants for national and international funding agencies, including the Department of Veterans Affairs, National Institutes of Health, and the Department of Defense. I am currently a regular member of the Radiation Therapeutics and Biology (RTB) Study Section of the NIH. I mentored numerous junior scientists at all levels (undergraduate, graduate, post-doctoral, and junior faculty). Many of my previous trainees/mentees have successfully obtained independent positions in academics and industry. In addition, I extensively collaborated with numerous scientists within the VA as well as at the University of Wisconsin, other universities in the U.S., and outside the country (internationally). I have always believed in the notion that `two heads are better than one'. A majority of my collaborations have been very successful, resulting in numerous papers and extramural funding. In summary, I believe that I am well qualified for the BLR&D Merit Review Research Career Scientist (RCS) Award, and I appreciate your consideration of my application.

我的长期职业目标是提高人类的生活质量，包括退伍军人，通过我的 research.我的实验室专注于两个广泛而互补的研究领域：1）癌症生物学和2） 癌症的预防和实验治疗。我的总体目标是确定关键的分子和 在癌症发展过程中发生的生物化学事件，反过来将有助于确定目标和新的 癌症管理的方法和策略。虽然对癌症感兴趣，但我最近的重点是 一直在皮肤癌和前列腺癌，这两种疾病都严重影响退伍军人群体。的实例 我实验室正在进行的研究如下。我们正在研究 有丝分裂调节因子，包括丝氨酸/苏氨酸激酶的polo样激酶（Plk）家族，以及这些因子如何 与其他重要的细胞信号通路相互作用，影响癌症的发展和进展。在 此外，我们正试图了解烟酰胺腺嘌呤二核苷酸（NAD）+依赖的作用， 在癌症的发展和/或进展中，去乙酰化酶，即Sirtuin家族蛋白。第二 我研究的主要重点是确定各种癌症化学预防/治疗潜力， 制剂，如白藜芦醇（一种在葡萄，坚果，浆果和红酒中发现的植物抗氧化剂），褪黑激素 (the松果体的主要分泌物和已知的抗氧化剂），维生素E（主要的抗氧化剂， 生物膜）和硒（人体必需的微量营养素）。我目前在退伍军人管理局赞助的研究中 重点是确定黑色素瘤发展和进展的机制。该研究领域是 与退伍军人事务部医疗保健极其相关，因为美国军方在世界各地执行任务，包括在 中东（伊拉克和阿富汗）。部署到这些区域会导致显著的紫外线照射暴露 这增加了从这些地区返回的退伍军人患恶性黑色素瘤的风险。基于几 据报道，驻扎在太平洋的二战老兵的黑色素瘤发病率增加 以及那些在越南的牧场之手行动中接触到二恶英污染的除草剂的人。我正在进行的 研究的目的是确定黑色素瘤发展的分子机制。我相信我的研究 研究结果正朝着确定管理这种致命肿瘤的新策略的方向发展。 因此，我的工作与退伍军人的医疗保健有关，意义重大，符合退伍军人协会的使命。 退伍军人事务部。我的研究成果发表在影响广泛的 科学期刊。发表论文170余篇，论文摘要150余篇，专著章节数篇（总计 引文：17，705; h-index，65; i10-index：1256来源：Google Scholar; 8/2016）。 我担任两个备受尊敬的杂志，毒理学和应用药理学的副编辑， 光化学和光生物学，并担任其他几种期刊的编委会成员。我是 经常应邀参加对国家和国际供资机构赠款的同行审查， 包括退伍军人事务部、国立卫生研究院和国防部。我 我目前是美国国立卫生研究院放射治疗学和生物学（RTB）研究科的正式成员。 我指导过许多不同层次的年轻科学家（本科生、研究生、博士后和大三学生 教师）。我以前的许多学员/学员都成功地获得了独立职位， 学术界和工业界。此外，我还与退伍军人事务部的许多科学家进行了广泛的合作， 就像在威斯康星州的大学一样，在美国的其他大学，国外（国际）。我有 我一直相信“两个脑袋比一个脑袋好”的观念。我的大部分合作都是 非常成功，导致了许多论文和校外资金。 总之，我认为我完全有资格担任BLR&D Merit Review Research Career Scientist (RCS)我很感激你能考虑我的申请。