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BLR&D Research Career Scientist Award Application

BLR

基本信息

批准号：
10265374
负责人：
Nihal Ahmad
金额：
--
依托单位：
WM S. MIDDLETON MEMORIAL VETERANS HOSP
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-04-01 至 2022-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10265374
关键词：
Academia Affect Afghanistan Antioxidants Area Award Berry Biochemical Biochemistry Biology Book Chapters Cancer Biology Chemopreventive Agent Clinical Collaborations Country Deacetylase Department of Defense Dermatology Development Dioxins Event Exposure to Extramural Activities Faculty Family Funding Funding Agency Goals Grant Grapes Hand Healthcare Herbicides Human Incidence Industry Institutes International Investigational Therapies Iraq Journals Laboratories Lead Life Malignant Neoplasms Malignant neoplasm of prostate Melatonin Mentors Micronutrients Middle East Military Personnel Mission Mitotic Molecular Names Neoplasms Nicotinamide adenine dinucleotide Nuts Oncogenes PLK1 gene Paper Peer Review Peer Review Grants Pharmacology Photobiology Photochemistry Pineal gland Positioning Attribute Postdoctoral Fellow Prevention Protein Family Protein-Serine-Threonine Kinases Publications Publishing Radiation Reporting Research Resveratrol Risk Role Scientist Selenium Services Signal Pathway Signal Transduction Signal Transduction Pathway Sirtuins Skin Cancer Source Study Section Therapeutic Toxicology Training United States Department of Veterans Affairs United States National Institutes of Health Universities Veterans Vietnam Vitamin E Wisconsin Work World War II anticancer research base career editorial graduate student improved indexing interest meetings melanoma member military veteran novel strategies operation phytoalexins red wine symposium tumor progression ultraviolet irradiation undergraduate student

项目摘要

My long-term career goal is to improve the quality of human life, including that of Veterans, through my research. My laboratory focuses on two broad and complimentary research areas: 1) cancer biology and 2) prevention and experimental therapeutics of cancer. My overall goal is to define the critical molecular and biochemical events that occur during cancer development that in turn will assist in identifying targets and new approaches and strategies for cancer management. While interested in cancer in general, my recent focus has been on skin and prostate cancers, both of which disproportionally affect the Veteran population. Examples of ongoing research in my laboratory are as follows. We are studying the role and functional significance of mitotic regulators, including the polo-like kinase (Plk) family of serine/threonine kinases, and how these factors interact with other important cell signaling pathways to influence cancer development and progression. In addition, we are trying to understand the role of nicotinamide adenine dinucleotide (NAD)+ -dependent deacetylases, namely the Sirtuin family proteins, in the development and/or progression of cancer. The second major focus of my research is to define the cancer chemopreventive/therapeutic potential of a variety of agents, such as resveratrol (a phytoalexin antioxidant found in grapes, nuts, berries and red wine), melatonin (the chief secretory product of the pineal gland and a known antioxidant), vitamin E (the major antioxidant in biomembranes) and selenium (an essential micronutrient for humans). My current VA-sponsored research focuses on identifying the mechanism of melanoma development and progression. This research area is extremely relevant to VA healthcare as the U.S. military engages in missions all over the world, including in the Middle East (Iraq and Afghanistan). Deployment to these regions results in significant UV irradiation exposure that increases the risk for malignant melanoma in the Veterans returning from these areas. Based on several studies, an increased incidence of melanoma was reported for World War II Veterans stationed in the Pacific and those exposed to dioxin-contaminated herbicides during Operation Ranch Hand in Vietnam. My ongoing research aims at defining the molecular mechanism of melanoma development. I believe that my research findings are moving towards the identification of novel strategies for the management of this deadly neoplasm. Thus, my work is relevant and significant to Veteran's healthcare and is in line with the mission of the Department of Veterans Affairs. The results of my research are published in a wide range of high-impact scientific journals. I have published more than 170 papers, 150 abstracts and several book chapters (Total Citations: 17,705; h-index, 65; i10-index: 1256 Source: Google Scholar; 8/2016). I serve as an Associate Editor of two well-respected journals, Toxicology and Applied Pharmacology and Photochemistry and Photobiology, and am a member of the Editorial Board of several other journals. I am regularly invited to participate in the peer-review of grants for national and international funding agencies, including the Department of Veterans Affairs, National Institutes of Health, and the Department of Defense. I am currently a regular member of the Radiation Therapeutics and Biology (RTB) Study Section of the NIH. I mentored numerous junior scientists at all levels (undergraduate, graduate, post-doctoral, and junior faculty). Many of my previous trainees/mentees have successfully obtained independent positions in academics and industry. In addition, I extensively collaborated with numerous scientists within the VA as well as at the University of Wisconsin, other universities in the U.S., and outside the country (internationally). I have always believed in the notion that `two heads are better than one'. A majority of my collaborations have been very successful, resulting in numerous papers and extramural funding. In summary, I believe that I am well qualified for the BLR&D Merit Review Research Career Scientist (RCS) Award, and I appreciate your consideration of my application.

我的长期职业目标是提高人类的生活质量，包括退伍军人的生活质量