Clinical neuroscience of alcoholism: integrating neuroscience and clinical trials

酗酒的临床神经科学：神经科学与临床试验的结合

• 批准号: 10481839
• 负责人: LARA A. RAY
• 金额: $ 18.39万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10481839
• 关键词: Address; Alcohol consumption; Alcoholism; Alcohols; Area; Award; Clinical; Clinical Investigator; Clinical Psychology; Clinical Research; Clinical Trials; Data; Data Analyses; Data Set; Development; Educational process of instructing; Faculty; Funding; Generations; Goals; Group Meetings; Heterogeneity; Human; Individual; Laboratories; Laboratory Research; Laboratory Study; Latina; Levetiracetam; Manuscripts; Mentors; Mentorship; Methods; Modeling; National Institute on Alcohol Abuse and Alcoholism; Neurosciences; Participant; Patients; Pharmaceutical Preparations; Pharmacology Study; Phenotype; Postdoctoral Fellow; Preparation; Publications; Reporting; Research; Research Ethics; Research Methodology; Research Personnel; Resources; Sampling; Science; Scientist; Self Administration; Services; Severities; Testing; Time; Training; Training Programs; Underrepresented Students; alcohol craving; alcohol cue; alcohol reinforcement; alcohol research; alcohol response; alcohol reward; behavioral pharmacology; behavioral study; career; career development; clinical investigation; cue reactivity; experience; graduate student; lectures; neuroimaging; novel; patient oriented; programs; quetiapine; research and development; response; screening; skills; student mentoring; synergism; therapy development; treatment comparison; undergraduate student; varenicline

PROJECT SUMMARY/ABSTRACT This application for a Mid-Career Investigator Award (K24) will provide Dr. Ray with the opportunity to continue her career development, mentorship of clinical investigators, and research in medications development for alcoholism. Consistent with the goal of supporting Dr. Ray’s career trajectory in AUD treatment development, the research aims are comprised of projects that will allow her to extend the impact of her research program in the areas of (a) neuroscience, (b) clinical trials, and (c) advanced quantitative methods. The ultimate research goal of the proposal is to integrate basic neuroscience and clinical trials methods to medications development for AUD. The mentoring plan will focus on continued training of undergraduate students, graduate students in clinical psychology, psychiatric residents, postdoctoral fellows, and junior faculty to conduct patient-oriented alcohol research. Dr. Ray will provide training in areas of clinical research methods, data analysis, data interpretation, manuscript preparation, grantsmanship, research ethics, and professional development. Mentoring occurs through Dr. Ray’s active research laboratory, which includes weekly individual and group meetings with trainees. Dr. Ray is active in providing lectures and seminars through multiple training programs at UCLA. In particular, Dr. Ray is committed to mentoring students from underrepresented backgrounds and as a Latina scientist, is sensitive to the issues of diversity in science. Through active participation in multiple programs aimed at diversifying the pool of alcohol scientists, Dr. Ray will broaden her impact in this arena. The training plan consists of coursework and training experiences in areas that are important to her career development as an investigator and mentor, particularly in the topics of basic neuroscience, clinical trials, and advanced quantitative methods. An outstanding group of collaborators has agreed to support Dr. Ray in her training goals. These areas of training and professional development have been selected in synergy with the research aims and ongoing funded-projects in Dr. Ray’s laboratory with the overarching goal of broadening the impact of her research program as well as that of her mentees. In summary, the support of the Mid-Career Investigator Award (K24) will allow Dr. Ray to devote her effort to patient-oriented alcohol research and research mentoring. She will also develop her own skill set through proposed training in basic neuroscience of AUD, clinical trials, and advanced quantitative methods while continuing to actively disseminate research findings along with her mentees through scientific presentations and publications. Through her mentoring, Dr. Ray is committed to training the new generation of patient-oriented alcohol researchers and will prioritize efforts to diversify the pool of junior scientists in the field of alcohol research.

项目摘要/摘要 申请职业生涯中期研究人员奖(K24)将为雷博士提供继续 她的职业发展、临床研究人员的指导以及药物开发方面的研究 酗酒。与支持Ray博士在AUD治疗开发方面的职业轨迹的目标一致， 研究目标由项目组成，这些项目将使她能够扩大她的研究计划在 (A)神经科学，(B)临床试验，和(C)先进的定量方法。终极研究 该提案的目标是将基础神经科学和临床试验方法整合到药物开发中 换成澳元。导师计划将重点放在继续培训本科生、研究生和 临床心理学、精神科住院医师、博士后研究员和初级教员以病人为导向 酒精研究。Ray博士将在临床研究方法、数据分析、数据 口译、手稿准备、专业技能、研究道德和专业发展。 辅导通过Ray博士的主动研究实验室进行，该实验室包括每周个人和小组 与实习生会面。雷博士积极通过多个培训项目提供讲座和研讨会 在加州大学洛杉矶分校。尤其是，雷博士致力于指导来自代表性不足的背景的学生，以及 一位拉丁裔科学家，对科学中的多样性问题很敏感。通过积极参与多个 旨在使酒精科学家群体多样化的项目，雷博士将扩大她在这一领域的影响力。这个 培训计划包括对她的职业生涯很重要的领域的课程工作和培训经验 作为研究人员和导师的发展，特别是在基础神经科学、临床试验和 先进的量化方法。一群杰出的合作者已经同意支持雷博士 培训目标。这些培训和专业发展领域的选择是与 雷博士实验室的研究目标和正在进行的资助项目，首要目标是扩大 她的研究计划以及她的导师的影响。总而言之，对职业生涯中期的支持 研究员奖(K24)将允许雷博士致力于以患者为导向的酒精研究和 研究指导。她还将通过拟议的基础神经科学培训来发展自己的技能。 AUD、临床试验和先进的定量方法，同时继续积极传播研究 通过科学报告和出版物，她与她的导师们一起研究了这一发现。通过她的指导，Dr。 雷致力于培养新一代以患者为导向的酒精研究人员，并将优先考虑 努力使酒精研究领域的初级科学家队伍多样化。

项目成果

Ibudilast moderates the effect of mood on alcohol craving during stress exposure.

• DOI: 10.1037/pha0000458
• 发表时间: 2022-10
• 期刊: Experimental and clinical psychopharmacology
• 影响因子: 2.3
• 作者: Meredith LR;Green R;Grodin EN;Chorpita M;Miotto K;Ray LA
• 通讯作者: Ray LA

Alcohol Use Among Treatment-Seeking Individuals With Opioid Use Disorder.

寻求治疗的阿片类药物使用障碍患者的饮酒情况。

• DOI: 10.15288/jsad.22-00176
• 发表时间: 2023
• 期刊: Journal of studies on alcohol and drugs
• 影响因子: 3.4
• 作者: Baskerville,Wave-Ananda;Grodin,EricaN;Lin,Johnny;Miotto,Karen;Mooney,LarissaJ;Ray,LaraA
• 通讯作者: Ray,LaraA

Alcohol use trajectories among U.S. adults during the first 42 weeks of the COVID-19 pandemic.

• DOI: 10.1111/acer.14824
• 发表时间: 2022-06
• 期刊: ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
• 作者: Leventhal, Adam M.;Cho, Junhan;Ray, Lara A.;Pacula, Rosalie Liccardo;Lee, Brian P.;Terrault, Norah;Pedersen, Eric;Lee, Jungeun Olivia;Davis, Jordan P.;Jin, Haomiao;Huh, Jimi;Wilson, John P.;Whaley, Reid C.
• 通讯作者: Whaley, Reid C.

Evaluation of delay discounting as a transdiagnostic research domain criteria indicator in 1388 general community adults.

• DOI: 10.1017/s0033291721005110
• 发表时间: 2023-03
• 期刊: PSYCHOLOGICAL MEDICINE
• 影响因子: 6.9
• 作者: Levitt, E. E.;Oshri, A.;Amlung, M.;Ray, L. A.;Sanchez-Roige, S.;Palmer, A. A.;MacKillop, J.
• 通讯作者: MacKillop, J.