Cancer Metabolism Training Program

癌症代谢培训计划

• 批准号: 10481834
• 负责人: David K Ann
• 金额: $ 21.93万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10481834
• 关键词: Training Programs; tumor metabolism

Cancer and metabolic dysfunction are closely related, and together they create unique therapeutic challenges. City of Hope (COH), an NCI-designated Comprehensive Cancer Center (COHCCC) located in Duarte, CA, is known internationally for clinical cancer research and groundbreaking diabetes research. Therefore, the Cancer Metabolism Training Program (CMTP), supported by a rapidly growing research infrastructure at COH, will bring together research experts in cancer and metabolism to train an elite group of dedicated postdoctoral fellows. The CMTP will focus on the link between cancer and metabolism, thereby connecting the long- standing COHCCC with the new COH Diabetes and Metabolism Research Institute. Faculty preceptors will direct research training in four primary areas: 1) Cancer Risk, Prevention, and Metabolism; 2) Cancer Metabolism Biology and Genetics; 3) Cancer Inflammation and Immune Cell Metabolism; and 4) Metabolism- Based Cancer Treatment. The training program includes an organized core curriculum consisting of courses in scientific and career development training, with individualized attention to best achieve each trainee’s personal goals and support the individual needs of a diverse trainee population. Courses in the Responsible Conduct of Research and Methods for Enhancing Reproducibility will also be required. Other associated activities include seminars, journal clubs, data clubs, and an annual Cancer Metabolism Day. The program is designed to take advantage of the existing institutional strengths, including well-established collaborations between cancer and diabetes/metabolism researchers. The CMTP has drawn 25 mentors from 12 departments, all of whom have robust funding profiles with high-profile publications, and are dedicated to preparing early career scientists for leadership roles in cancer research. Six promising early-career investigators will serve as co-mentors and participate in mentor development activities. The 3 NIH T32-supported postdoctoral trainees, supported for up to 3 years, will be selected through a rigorous process, including a personal interview. Trainees will be evaluated on their publications, applications for external funding, and participation in CMTP activities. The outstanding support from COH leadership includes 1) an additional trainee position for every underrepresented minority trainee recruited, up to a total of 6 positions; 2) salary supplementation for all CMTP trainees; 3) a stipend for research supplies; and 4) full administrative and faculty salary support. Each trainee will establish a Mentoring Committee, which will include a physician to expedite translational research. The CMTP leadership will include a Recruitment Committee to oversee national recruitment efforts, a Curriculum and Training Committee to oversee course development, an Executive Committee to evaluate and modify program components, and an Internal and External Advisory Board to independently assess program progress. The overall goal of the CMTP is to assist the transformation of promising researchers into strong independent, funded scientists with the capacity to make contributions that improve human health.

癌症和代谢功能障碍密切相关，它们共同带来了独特的治疗挑战。 位于加利福尼亚州杜阿尔特的NCI指定的综合癌症中心（COHCCC）的希望之城（COH）是 临床癌症研究和开创性糖尿病研究的国际知名度。因此， 癌症代谢培训计划（CMTP），由COH的迅速增长的研究基础设施支持， 将汇集癌症和代谢方面的研究专家，以培训一群精英的博士后。 研究员。 CMTP将重点关注癌症与代谢之间的联系，从而连接长期 与新的COH糖尿病和新陈代谢研究所一起站立的COHCCC。教师主持人会 在四个主要领域的直接研究培训：1）癌症风险，预防和代谢； 2）癌症 代谢生物学和遗传学； 3）癌症炎症和免疫细胞代谢； 4）代谢 - 基于癌症治疗。培训计划包括一个有组织的核心课程，该课程包括 科学和职业发展培训，并具有个性化的关注，以最能实现每个学员的个人 目标并支持潜水员学员人口的个人需求。负责任的课程 还需要研究和提高可重复性的方法。其他相关活动包括 半人物，期刊俱乐部，数据俱乐部和年度癌症代谢日。该程序旨在采用 现有机构优势的优势，包括癌症与 糖尿病/代谢研究人员。 CMTP从12个部门吸引了25名导师 具有备受瞩目的出版物的强大资助资料，并致力于为早期职业科学家做准备 在癌症研究中的领导作用。六个诺言早期调查人员将担任联合委员会和 参加导师发展活动。 3个NIH T32支持的博士后学员，支持UP 到3年，将通过严格的过程进行选择，包括个人面试。学员会 在其出版物，外部资金申请和参与CMTP活动中进行了评估。 COH领导层的出色支持包括1）每个人为不足的额外的学员职位 少数民族学员招募，总共有6个职位； 2）为所有CMTP受训人员补充工资； 3）a 研究用品的津贴； 4）全部行政和教师薪资支持。每个学员将建立一个 指导委员会，其中包括一名物理学来加快转化研究。 CMTP领导 将包括一个招聘委员会，参加海外国家招聘工作，课程和培训 监督课程开发的委员会，执行委员会评估和修改计划 组件以及内部和外部顾问委员会，以独立评估计划的进度。 CMTP的总体目标是帮助有前途的研究人员转变为强大的独立， 资助的科学家有能力做出改善人类健康的贡献。

项目成果

Niraparib-induced STAT3 inhibition increases its antitumor effects.

• DOI: 10.3389/fonc.2022.966492
• 发表时间: 2022
• 期刊: FRONTIERS IN ONCOLOGY
• 影响因子: 4.7
• 作者: Zhao, Qianqian;Kohut, Adrian;Li, Yi-Jia;Martincuks, Antons;Austria, Theresa;Zhang, Chunyan;Santiago, Nicole Lugo;Borrero, Rosemarie Martinez;Phan, Xuan Thuy;Melstrom, Laleh;Rodriguez-Rodriguez, Lorna;Yu, Hua
• 通讯作者: Yu, Hua

Tissue aging: the integration of collective and variant responses of cells to entropic forces over time.

• DOI: 10.1016/j.ceb.2018.05.016
• 发表时间: 2018-10
• 期刊: Current opinion in cell biology
• 影响因子: 7.5
• 作者: Todhunter ME;Sayaman RW;Miyano M;LaBarge MA
• 通讯作者: LaBarge MA