Tumor Metabolism

摘要 支持是要求为基石研讨会会议题为肿瘤代谢，由博士组织。 白色，约书亚D.作者：Rabinowitz Haigis和大卫M.萨巴蒂尼会议预计 将于2022年2月6日至10日在加拿大班夫举行。 肿瘤代谢领域是癌症生物学中最古老的领域之一，可以追溯到奥托的开创性工作 20世纪20年代的瓦尔堡。肿瘤代谢的临床重要性通过以下两个方面的成功得到了很好的验证： FDG-PET成像和作为化疗剂的抗代谢物。认识到癌基因 促进瓦尔堡效应和激活合成代谢途径为振兴考试提供了动力 肿瘤代谢的影响。这次会议汇集了肿瘤代谢的领导者，讨论正在进行的努力 了解和靶向增殖癌细胞及其支持网络的代谢。这次会议 将解决有关增殖细胞代谢的关键问题， 体内肿瘤，以及治疗干预的相关机会，包括在 代谢和免疫疗法。会议将涉及的关键科学问题包括（1） 癌细胞代谢的特征在增殖细胞中是共享的，哪些是癌症特异性的？(2)如何 信号驱动新陈代谢，新陈代谢如何影响信号和细胞命运的决定？以及（3） 肿瘤对宿主代谢的依赖性是什么，肿瘤代谢对宿主的影响是什么 细胞，包括入侵的淋巴细胞？这次会议与2010年12月15日至16日在日内瓦举行的 “肥胖和癌症交叉路口的免疫代谢”，我们的目标是协同解决如何 营养过剩、微生物组和肿瘤微环境中免疫细胞的代谢影响 这种抗癌免疫反应。通过讨论这些问题和其他问题，会议的目的是 产生新的科学思想，促进合作，加强最新技术的传播 和代谢研究的最佳实践。作为分享肿瘤领域重要未发表数据的首要场所， 代谢领域，本次会议将有助于加速科学发现和新的发展， 治疗癌症的策略。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Tumor Metabolism, organized by Drs. Eileen P. White, Joshua D. Rabinowitz, Marcia C. Haigis and David M. Sabatini. The conference is anticipated to be held in Banff, Canada from February 6-10, 2022. The field of tumor metabolism is one of the oldest in cancer biology, dating back to the seminal work of Otto Warburg in the 1920s. Clinical importance of tumor metabolism is well validated by the successes both of FDG-PET imaging and of antimetabolites as chemotherapeutic agents. The recognition that oncogenes both promote the Warburg effect and activate anabolic pathways has provided impetus for revitalized examination of tumor metabolism. This conference brings together leaders in tumor metabolism to discuss ongoing efforts to understand and target metabolism of proliferating cancer cells and their support network. This conference will address key questions regarding the metabolism of proliferating cells, the unique metabolic features of tumors in vivo, and the associated opportunities for therapeutic intervention, including at the interface between metabolism and immunotherapy. Key scientific questions that conference session will cover include (1) which features of cancer cell metabolism are shared across proliferating cells, and which are cancer specific? (2) how does signaling drive metabolism, and how does metabolism impact signaling and cell fate decisions? and (3) what are the dependencies of tumors on host metabolism, and what is the impact of tumor metabolism on host cells, including invading lymphocytes? By holding this meeting jointly with the Keystone meeting on “Immunometabolism at the Crossroads of Obesity and Cancer” we aim to synergistically address how overnutrition, the microbiome, and the metabolism of immune cells in the tumor microenvironment influences that anti-cancer immune response. Through discussion of these and other questions, the conference aims to generate new scientific ideas, promote collaborations, and enhance dissemination of the latest technologies and best practices for metabolic studies. As the premier venue sharing important unpublished data in the tumor metabolism field, this conference will help to accelerate scientific discovery and the development of new strategies to treat cancer.