Tumor Metabolism

肿瘤代谢

• 批准号: 10391399
• 负责人: Thale Cross Jarvis
• 金额: $ 0.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-03 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10391399
• 关键词: Address; Antimetabolites; Back; Canada; Cancer Biology; Cells; Clinical; Collaborations; Data; Dependence; Development; Educational workshop; Future; Immune; Immune response; Immunotherapy; Industrialization; Invaded; Knowledge; Lymphocyte; Malignant Neoplasms; Mentors; Metabolic; Metabolism; Methodology; Obesity; Oncogenes; Outcome; Overnutrition; Pathway interactions; Positron-Emission Tomography; Proliferating; Research; Research Personnel; Scientist; Seminal; Signal Transduction; Technology; Therapeutic; Therapeutic Intervention; Warburg Effect; Work; anti-cancer; cancer cell; chemotherapeutic agent; clinical practice; clinical translation; design; drug metabolism; fluorodeoxyglucose positron emission tomography; in vivo; interest; meetings; metabolic abnormality assessment; microbiome; posters; prospective; success; support network; symposium; tumor; tumor metabolism; tumor microenvironment

ABSTRACT Support is requested for a Keystone Symposia conference entitled Tumor Metabolism, organized by Drs. Eileen P. White, Joshua D. Rabinowitz, Marcia C. Haigis and David M. Sabatini. The conference is anticipated to be held in Banff, Canada from February 6-10, 2022. The field of tumor metabolism is one of the oldest in cancer biology, dating back to the seminal work of Otto Warburg in the 1920s. Clinical importance of tumor metabolism is well validated by the successes both of FDG-PET imaging and of antimetabolites as chemotherapeutic agents. The recognition that oncogenes both promote the Warburg effect and activate anabolic pathways has provided impetus for revitalized examination of tumor metabolism. This conference brings together leaders in tumor metabolism to discuss ongoing efforts to understand and target metabolism of proliferating cancer cells and their support network. This conference will address key questions regarding the metabolism of proliferating cells, the unique metabolic features of tumors in vivo, and the associated opportunities for therapeutic intervention, including at the interface between metabolism and immunotherapy. Key scientific questions that conference session will cover include (1) which features of cancer cell metabolism are shared across proliferating cells, and which are cancer specific? (2) how does signaling drive metabolism, and how does metabolism impact signaling and cell fate decisions? and (3) what are the dependencies of tumors on host metabolism, and what is the impact of tumor metabolism on host cells, including invading lymphocytes? By holding this meeting jointly with the Keystone meeting on “Immunometabolism at the Crossroads of Obesity and Cancer” we aim to synergistically address how overnutrition, the microbiome, and the metabolism of immune cells in the tumor microenvironment influences that anti-cancer immune response. Through discussion of these and other questions, the conference aims to generate new scientific ideas, promote collaborations, and enhance dissemination of the latest technologies and best practices for metabolic studies. As the premier venue sharing important unpublished data in the tumor metabolism field, this conference will help to accelerate scientific discovery and the development of new strategies to treat cancer.

摘要 请求支持由博士组织的题为肿瘤代谢的Keystone研讨会。 题名/责任者：The First of the First，and and the First of the First.这次会议令人期待。 将于2022年2月6日至10日在加拿大班夫举行。 肿瘤代谢领域是癌症生物学中最古老的领域之一，可以追溯到奥托的开创性工作。 20世纪20年代的华堡。两项研究的成功充分证明了肿瘤代谢的临床重要性。 FDG-PET成像和抗代谢药物作为化疗药物的研究。认识到癌基因既有 推动华宝效应，激活合成代谢通路，为振兴考试提供了动力 肿瘤的新陈代谢。这次会议汇聚了肿瘤新陈代谢领域的领袖，讨论正在进行的努力。 了解和靶向增殖癌细胞及其支持网络的新陈代谢。这次会议 将解决有关增殖细胞新陈代谢的关键问题，即 体内肿瘤，以及相关的治疗干预机会，包括在 新陈代谢和免疫治疗。会议将讨论的关键科学问题包括(1) 癌细胞代谢的特征在增殖细胞中是相同的，哪些是癌症特有的？(2)如何 信号是否驱动新陈代谢，新陈代谢如何影响信号和细胞命运的决定？和(3) 肿瘤对宿主代谢的依赖性是什么，肿瘤代谢对宿主的影响是什么 细胞，包括入侵的淋巴细胞？通过与Keystone会议联合举行这次会议 “肥胖和癌症的十字路口的免疫新陈代谢”我们的目标是协同解决 肿瘤微环境中的营养过剩、微生物群和免疫细胞的新陈代谢都会影响 抗癌免疫反应。通过对这些问题和其他问题的讨论，会议旨在 产生新的科学思想，促进合作，加强最新技术的传播 和代谢研究的最佳实践。作为共享肿瘤中重要的未发表数据的首要场所 新陈代谢领域，这次会议将有助于加快科学发现和新技术的发展 治疗癌症的策略。