Tumor Metabolism
Tumor Metabolism
批准号:
10391399
负责人:
Thale Cross Jarvis
金额:
$0.5万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-12-03 至 2022-11-30
关键词:
AddressAntimetabolitesBackCanadaCancer BiologyCellsClinicalCollaborationsDataDependenceDevelopmentEducational workshopFutureImmuneImmune responseImmunotherapyIndustrializationInvadedKnowledgeLymphocyteMalignant NeoplasmsMentorsMetabolicMetabolismMethodologyObesityOncogenesOutcomeOvernutritionPathway interactionsPositron-Emission TomographyProliferatingResearchResearch PersonnelScientistSeminalSignal TransductionTechnologyTherapeuticTherapeutic InterventionWarburg EffectWorkanti-cancercancer cellchemotherapeutic agentclinical practiceclinical translationdesigndrug metabolismfluorodeoxyglucose positron emission tomographyin vivointerestmeetingsmetabolic abnormality assessmentmicrobiomepostersprospectivesuccesssupport networksymposiumtumortumor metabolismtumor microenvironment
中文摘要
摘要
英文摘要
ABSTRACT
Support is requested for a Keystone Symposia conference entitled Tumor Metabolism, organized by Drs.
Eileen P. White, Joshua D. Rabinowitz, Marcia C. Haigis and David M. Sabatini. The conference is anticipated
to be held in Banff, Canada from February 6-10, 2022.
The field of tumor metabolism is one of the oldest in cancer biology, dating back to the seminal work of Otto
Warburg in the 1920s. Clinical importance of tumor metabolism is well validated by the successes both of
FDG-PET imaging and of antimetabolites as chemotherapeutic agents. The recognition that oncogenes both
promote the Warburg effect and activate anabolic pathways has provided impetus for revitalized examination
of tumor metabolism. This conference brings together leaders in tumor metabolism to discuss ongoing efforts
to understand and target metabolism of proliferating cancer cells and their support network. This conference
will address key questions regarding the metabolism of proliferating cells, the unique metabolic features of
tumors in vivo, and the associated opportunities for therapeutic intervention, including at the interface between
metabolism and immunotherapy. Key scientific questions that conference session will cover include (1) which
features of cancer cell metabolism are shared across proliferating cells, and which are cancer specific? (2) how
does signaling drive metabolism, and how does metabolism impact signaling and cell fate decisions? and (3)
what are the dependencies of tumors on host metabolism, and what is the impact of tumor metabolism on host
cells, including invading lymphocytes? By holding this meeting jointly with the Keystone meeting on
“Immunometabolism at the Crossroads of Obesity and Cancer” we aim to synergistically address how
overnutrition, the microbiome, and the metabolism of immune cells in the tumor microenvironment influences
that anti-cancer immune response. Through discussion of these and other questions, the conference aims to
generate new scientific ideas, promote collaborations, and enhance dissemination of the latest technologies
and best practices for metabolic studies. As the premier venue sharing important unpublished data in the tumor
metabolism field, this conference will help to accelerate scientific discovery and the development of new
strategies to treat cancer.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Bioenergetics in Health and Diseases
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批准号:10609120
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项目类别:
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资助金额:$1.74万
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财政年份:2023
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负责人:Thale Cross Jarvis
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依托单位:
Autophagy and Neurodegeneration: Mechanisms to Therapies
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批准号:10608666
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项目类别:
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资助金额:$1.5万
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财政年份:2023
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负责人:Thale Cross Jarvis
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Adipose Tissue: Energizing Good Fat
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批准号:10609127
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项目类别:
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资助金额:$2.02万
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财政年份:2023
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负责人:Thale Cross Jarvis
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依托单位:
Cancer Neoantigens, Vaccines and Viruses
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批准号:10233861
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项目类别:
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资助金额:$0.5万
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财政年份:2022
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负责人:Thale Cross Jarvis
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依托单位:
Small Regulatory RNAs: From Bench to Bedside
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批准号:10462420
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项目类别:
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资助金额:$0.5万
-
财政年份:2022
-
负责人:Thale Cross Jarvis
-
依托单位:
Engineering Multi-Cellular Living Systems
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批准号:10462913
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项目类别:
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资助金额:$1.5万
-
财政年份:2022
-
负责人:Thale Cross Jarvis
-
依托单位:
Malaria: Confronting Challenges From Drug Discovery to Treatment
-
批准号:10468493
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项目类别:
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资助金额:$0.5万
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财政年份:2022
-
负责人:Thale Cross Jarvis
-
依托单位:
Gut-Brain Axis
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批准号:10467819
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项目类别:
-
资助金额:$1.72万
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财政年份:2022
-
负责人:Thale Cross Jarvis
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依托单位:
The Human Microbiome: Ecology and Evolution
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批准号:10391370
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项目类别:
-
资助金额:$0.5万
-
财政年份:2022
-
负责人:Thale Cross Jarvis
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依托单位:
Modern Phenotypic Drug Discovery: From Chemical Biology to Therapeutics
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批准号:10468419
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项目类别:
-
资助金额:$1.72万
-
财政年份:2022
-
负责人:Thale Cross Jarvis
-
依托单位:
Progress in Vaccine Development for Infectious Diseases
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批准号:10467880
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项目类别:
-
资助金额:$0.55万
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财政年份:2022
-
负责人:Thale Cross Jarvis
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依托单位:
Tissue Fibrosis and Repair: Mechanisms, Human Disease and Therapies
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批准号:10462412
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项目类别:
-
资助金额:$1.8万
-
财政年份:2022
-
负责人:Thale Cross Jarvis
-
依托单位:
Drug Delivery to the Brain: Challenges and Progress
-
批准号:10540503
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项目类别:
-
资助金额:$1.77万
-
财政年份:2022
-
负责人:Thale Cross Jarvis
-
依托单位:
Neurocircuitry of Social Behavior
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批准号:10540465
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项目类别:
-
资助金额:$1.2万
-
财政年份:2022
-
负责人:Thale Cross Jarvis
-
依托单位:
Resolution of Inflammation
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批准号:10469175
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项目类别:
-
资助金额:$0.9万
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财政年份:2022
-
负责人:Thale Cross Jarvis
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依托单位:
Organoids as Tools for Fundamental Discovery and Translation
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批准号:10469084
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项目类别:
-
资助金额:$1.5万
-
财政年份:2022
-
负责人:Thale Cross Jarvis
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依托单位:
Novel Approaches Against Emerging Antimicrobial Resistance
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批准号:10391767
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项目类别:
-
资助金额:$1.1万
-
财政年份:2022
-
负责人:Thale Cross Jarvis
-
依托单位:
Precision Genome Engineering
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批准号:10391367
-
项目类别:
-
资助金额:$2.22万
-
财政年份:2022
-
负责人:Thale Cross Jarvis
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依托单位:
Neuronal Control of Appetite
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批准号:10468571
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项目类别:
-
资助金额:$2.0万
-
财政年份:2022
-
负责人:Thale Cross Jarvis
-
依托单位:
Innate Immunity: Complement and Beyond
-
批准号:10464340
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项目类别:
-
资助金额:$1.1万
-
财政年份:2022
-
负责人:Thale Cross Jarvis
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依托单位:
海外基金