Cancer Metabolism Training Program

癌症代谢培训计划

• 批准号: 9766219
• 负责人: David K Ann
• 金额: $ 21.58万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9766219
• 关键词: Training Programs; tumor metabolism

Cancer and metabolic dysfunction are closely related, and together they create unique therapeutic challenges. City of Hope (COH), an NCI-designated Comprehensive Cancer Center (COHCCC) located in Duarte, CA, is known internationally for clinical cancer research and groundbreaking diabetes research. Therefore, the Cancer Metabolism Training Program (CMTP), supported by a rapidly growing research infrastructure at COH, will bring together research experts in cancer and metabolism to train an elite group of dedicated postdoctoral fellows. The CMTP will focus on the link between cancer and metabolism, thereby connecting the long- standing COHCCC with the new COH Diabetes and Metabolism Research Institute. Faculty preceptors will direct research training in four primary areas: 1) Cancer Risk, Prevention, and Metabolism; 2) Cancer Metabolism Biology and Genetics; 3) Cancer Inflammation and Immune Cell Metabolism; and 4) Metabolism- Based Cancer Treatment. The training program includes an organized core curriculum consisting of courses in scientific and career development training, with individualized attention to best achieve each trainee’s personal goals and support the individual needs of a diverse trainee population. Courses in the Responsible Conduct of Research and Methods for Enhancing Reproducibility will also be required. Other associated activities include seminars, journal clubs, data clubs, and an annual Cancer Metabolism Day. The program is designed to take advantage of the existing institutional strengths, including well-established collaborations between cancer and diabetes/metabolism researchers. The CMTP has drawn 25 mentors from 12 departments, all of whom have robust funding profiles with high-profile publications, and are dedicated to preparing early career scientists for leadership roles in cancer research. Six promising early-career investigators will serve as co-mentors and participate in mentor development activities. The 3 NIH T32-supported postdoctoral trainees, supported for up to 3 years, will be selected through a rigorous process, including a personal interview. Trainees will be evaluated on their publications, applications for external funding, and participation in CMTP activities. The outstanding support from COH leadership includes 1) an additional trainee position for every underrepresented minority trainee recruited, up to a total of 6 positions; 2) salary supplementation for all CMTP trainees; 3) a stipend for research supplies; and 4) full administrative and faculty salary support. Each trainee will establish a Mentoring Committee, which will include a physician to expedite translational research. The CMTP leadership will include a Recruitment Committee to oversee national recruitment efforts, a Curriculum and Training Committee to oversee course development, an Executive Committee to evaluate and modify program components, and an Internal and External Advisory Board to independently assess program progress. The overall goal of the CMTP is to assist the transformation of promising researchers into strong independent, funded scientists with the capacity to make contributions that improve human health.

癌症和代谢功能障碍密切相关，它们共同构成了独特的治疗挑战。 位于加利福尼亚州杜阿尔特的NCI指定的综合癌症中心(COHCCC)是希望之城(COH) 因临床癌症研究和突破性的糖尿病研究而闻名国际。因此， 癌症代谢培训计划(CMTP)，由COH快速增长的研究基础设施支持， 将汇聚癌症和新陈代谢方面的研究专家，培养一批敬业的博士后精英 伙计们。CMTP将专注于癌症和新陈代谢之间的联系，从而将长期的- COHCCC与新的COH糖尿病和代谢研究所合作。教职教官将 四个主要领域的直接研究培训：1)癌症风险、预防和新陈代谢；2)癌症 代谢生物学和遗传学；3)癌症炎症和免疫细胞代谢；4)新陈代谢- 以癌症治疗为基础。培训计划包括一个有组织的核心课程，由以下课程组成 科学和职业发展培训，个性化关注，最大限度地实现每个学员的个人 目标和支持不同受训人口的个人需求。负责任的行为课程 还需要加强可重复性的研究和方法。其他相关活动包括 研讨会、杂志俱乐部、数据俱乐部，以及一年一度的癌症代谢日。该计划旨在采取 利用现有的机构优势，包括癌症和癌症之间业已建立的合作 糖尿病/代谢研究人员。CMTP吸引了来自12个部门的25名导师，他们都有 通过高知名度的出版物提供强大的资金支持，致力于为早期职业科学家做好准备 在癌症研究中的领导作用。六名有前途的早期调查人员将担任联合导师和 参与导师发展活动。NIH T32资助的3名博士后实习生，最多支持 到3年，将通过包括个人面试在内的严格程序进行遴选。实习生将是 根据其出版物、外部资金申请和对CMTP活动的参与情况进行评估。这个 来自COH领导层的杰出支持包括：1)每一个任职人数不足的人就增加一个实习生职位 招聘少数族裔实习生，总共最多6个职位；2)为所有CMTP实习生提供薪金补充；3)a) 研究用品的津贴；以及4)全额行政和教师工资支持。每个实习生将建立一个 指导委员会，其中将包括一名医生，以加快翻译研究。CMTP领导层 将包括一个招聘委员会，以监督国家招聘工作、课程和培训 监督课程发展的委员会，评估和修改计划的执行委员会 各组成部分，以及独立评估方案进展情况的内部和外部咨询委员会。这个 CMTP的总体目标是帮助有前途的研究人员转变为强大的独立性， 资助有能力为改善人类健康作出贡献的科学家。