IGNITE KUH NRSA Training Core

IGNITE KUH NRSA 培训核心

• 批准号: 10483193
• 负责人: DIDIER PORTILLA
• 金额: $ 40.4万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10483193
• 关键词: Acute Renal Failure with Renal Papillary Necrosis; Address; Adult; Advocacy; Affect; American; Anti-Cholinergics; Anti-Inflammatory Agents; Area; Attenuated; Basic Science; Benign; Bioenergetics; Biology; Biomechanics; Biomedical Engineering; Blood; Career Choice; Childhood; Chronic Kidney Insufficiency; Cisplatin; Clinical Research; Clinical Sciences; Clinical and Translational Science Awards; Cohort Studies; Communication; Cystoscopy; Data Science; Dendritic Cells; Development; Disease; Doctor of Philosophy; Endothelium; FGF2 gene; Faculty; Future; General Population; Goals; HL-60 Cells; Health; Healthcare Systems; Hematological Disease; Hematology; Historically Black Colleges and Universities; Human; Immunity; Individual; Inflammation; Infrastructure; Injury; Institutes; Institution; Interferon Type II; Kidney; Kidney Diseases; Lead; Lipids; Mediating; Medical; Methods; Microbubbles; Mitochondria; Mole the mammal; National Research Service Awards; Nephrology; Nephrons; Neuroimmune; Operative Surgical Procedures; Pathway interactions; Patients; Physicians; Postdoctoral Fellow; Predictive Analytics; Price; Recovery; Reperfusion Injury; Research; Research Institute; Research Personnel; Research Training; Resistance; Resuscitation; Risk Factors; Role; Scientist; Societies; Sphingolipids; Sphingosine; Sphingosine-1-Phosphate Receptor; Students; Surgeon; System; Systems Biology; Therapeutic; Training; Training Programs; Training and Education; Translational Research; Ultrasonics; Underrepresented Populations; Underrepresented Students; United States; Universities; Urologic Diseases; Urology; Virginia; Washington; chemotherapy; clinical center; cohesion; diabetic; doctoral student; drug discovery; functional genomics; human disease; innovation; kidney fibrosis; medical specialties; nanoparticle delivery; nanotherapeutic; next generation; non-diabetic; novel; pressure; prevent; programs; receptor; recruit; renal ischemia; rosin; sphingosine 1-phosphate; sphingosine kinase; success; targeted delivery; telecare; trend; ultrasound; workforce needs

Contact PD/PI: Okusa, Mark D. NRSA-Training-001 (883) NRSA TRAINING CORE ABSTRACT The Integrated Virginia Research Training Centers in Kidney, Urology and Hematology (IGNITE KUH) training program is being proposed to address an unmet need and major gap in prioritized research training through development and integration of a statewide research program in the Commonwealth of Virginia. The IGNITE KUH NRSA Training Core is an innovative and distinctive multi-institutional, multi-departmental program comprising a team of 65 outstanding faculty from the University of Virginia (UVA), Virginia Commonwealth University (VCU), and Virginia Polytechnic Institute and State University (VT) with primary research programs anchored in the basic research and clinical science of benign KUH diseases in six thematic areas: Systems Biology and Functional Genomics, Immunity and Inflammation, Biomedical Engineering, Nanotherapeutics and Drug Discovery, Clinical and Data Sciences, and Predictive Analytics. The NRSA Training Core leverages existing strengths in kidney and hematological disease research, uniting them with urological disease research in a cohesive, integrated and coordinated research training program. The NRSA Training Core will be enhanced through participation and integration of the Translational Health Research Institute of Virginia (iTHRIV), a component of the Clinical and Translational Science Award (CTSA) partnership between UVA and VT, and the Wright Center for Clinical and Translational Research (CCTR) at VCU. Three major goals of the IGNITE KUH NRSA Training Core include: 1) increase training of PhD students, residents (urology) and postdoctoral fellows in basic and translational aspects of KUH in health and disease using a unified approach; 2) establish an integrated Virginia-wide research training program focused on KUH-diseases; and 3) attract outstanding students and postdoctoral fellows with long-term career interests in basic or clinical research into the IGNITE KUH Training Program. IGNITE KUH will prioritize strategies to attract students from underrepresented populations at several partner institutions, including three historically black universities in Virginia – Virginia State University (VSU), Hampton University (HU), and Virginia Union Universities (VUU) – thereby further enhancing development and training of both PhD researchers and physician scientists. The IGNITE KUH NRSA Training Core will address human health issues through increased education and training of the next generation of researchers and physician scientists in basic research or clinical science who can guide and lead future research programs aiming to lessen human disease and suffering in KUH-specific fields. Project Summary/Abstract Page 322 Contact PD/PI: Okusa, Mark D. NRSA-Training-001 (883) References 1. Jager KJ, Kovesdy C, Langham R, Rosenberg M, Jha V, Zoccali C. A single number for advocacy and communication-worldwide more than 850 million individuals have kidney diseases. Kidney Int 2019;96:1048-50. 2. Stapleton FB, Andreoli S, Ettenger R, Kamil E, Sedman A, Chesney R. Future workforce needs for pediatric nephrology: an analysis of the nephrology workforce and training requirements by the Workforce Committee of the American Society of Pediatric Nephrology. J Am Soc Nephrol 1997;8:S5-8. 3. Rosner MH, Berns JS. Transforming Nephrology. Clin J Am Soc Nephrol 2018;13:331-4. 4. de Boer IH. Nephrology at a Crossroads. Clin J Am Soc Nephrol 2018;13:324. 5. Lane CA, Brown MA. Nephrology: a specialty in need of resuscitation? Kidney Int 2009;76:594-6. 6. Tonelli M, Wiebe N, Manns BJ, et al. Comparison of the Complexity of Patients Seen by Different Medical Subspecialists in a Universal Health Care System. JAMA Netw Open 2018;1:e184852. 7. McKibben MJ, Kirby EW, Langston J, et al. Projecting the Urology Workforce Over the Next 20 Years. Urology 2016;98:21-6. 8. Washington SL, 3rd, Baradaran N, Gaither TW, et al. Racial distribution of urology workforce in United States in comparison to general population. Transl Androl Urol 2018;7:526-34. 9. Woldu SL, Raj GV. Surgery: The surgeon-scientist - a dying breed? Nat Rev Urol 2016;13:698-9. 10. Keswani SG, Moles CM, Morowitz M, et al. The Future of Basic Science in Academic Surgery: Identifying Barriers to Success for Surgeon-scientists. Ann Surg 2017;265:1053-9. 11. Hougen HY, Lobo JM, Corey T, et al. Optimizing and validating the technical infrastructure of a novel tele- cystoscopy system. J Telemed Telecare 2016;22:397-404. 12. Sharma D, Wallace N, Levinsohn EA, et al. Trends and factors affecting the US adult hematology workforce: a mixed methods study. Blood Adv 2019;3:3550-61. 13. Hoots WK, Abkowitz JL, Coller BS, DiMichele DM. Planning for the future workforce in hematology research. Blood 2015;125:2745-52. 14. Soffer E, Hoots WK. Challenges facing the benign hematology physician-scientist workforce: identifying issues of recruitment and retention. Blood Adv 2018;2:308. 15. Perry HM, Huang L, Ye H, et al. Endothelial Sphingosine 1Phosphate Receptor1 Mediates Protection and Recovery from Acute Kidney Injury. J Am Soc Nephrol 2016;27:3383-93. 16. Bajwa A, Huang L, Kurmaeva E, et al. Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN-gamma. J Am Soc Nephrol 2016;28:1145-61. 17. Bajwa A, Rosin DL, Chroscicki P, et al. Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury. J Am Soc Nephrol 2014. 18. Bajwa A, Huang L, Ye H, et al. Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury. J Immunol 2012;189:2584-96. 19. Bajwa A, Jo SK, Ye H, et al. Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury. J Am Soc Nephrol 2010;21:955-65. 20. Jo SK, Bajwa A, Ye H, et al. Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury. Kidney Int 2009;75:167-75. 21. Jo SK, Bajwa A, Awad AS, Lynch KR, Okusa MD. Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney disease. Kidney Int 2008;73:1220-30. 22. Kao LP, Morad SAF, Davis TS, et al. Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells. J Lipid Res 2019;60:1590-602. 23. Gigliotti JC, Huang L, Ye H, et al. Ultrasound prevents renal ischemia-reperfusion injury by stimulating the splenic cholinergic anti-inflammatory pathway. J Am Soc Nephrol 2013;24:1451-60. 24. Tanaka S, Inoue T, Hossack JA, Okusa MD. Nonpharmacological, Biomechanical Approaches to Control Inflammation in Acute Kidney Injury. Nephron 2017;137:277-81. 25. Gigliotti JC, Huang L, Bajwa A, et al. Ultrasound Modulates the Splenic Neuroimmune Axis in Attenuating AKI. J Am Soc Nephrol 2015;26:2407-81. 26. Chappell JC, Song J, Burke CW, Klibanov AL, Price RJ. Targeted delivery of nanoparticles bearing fibroblast growth factor-2 by ultrasonic microbubble destruction for therapeutic arteriogenesis. Small 2008;4:1769-77. 27. Anderson AH, Xie D, Wang X, et al. Novel Risk Factors for Progression of Diabetic and Nondiabetic CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis 2020. References Cited Page 323

联系PD/PI：Okusa，Mark D. NRSA-Training-001（883） NRSA培训核心摘要 肾脏，泌尿外科和血液学的综合研究培训中心（点燃 提议提出培训计划，以满足未满足的需求和主要差距 通过开发和整合全州研究计划的研究培训 弗吉尼亚州的联邦。点燃的Kuh NRSA培训核心是一种创新和独特的 多机构的多部门计划，完成了一支由65个杰出教师组成的团队 弗吉尼亚大学（UVA），弗吉尼亚联邦大学（VCU）和弗吉尼亚大学 理工学院和州立大学（VT）的主要研究计划锚定 良性KUH疾病的基础研究和临床科学在六个主题领域：系统 生物学和功能基因组学，免疫和炎症，生物医学工程， 纳米治疗和药物发现，临床和数据科学以及预测分析。这 NRSA训练核心利用肾脏和血液学疾病研究中的现有优势， 将它们与泌尿外科研究结合在凝聚力，整合和协调的研究中 培训计划。 NRSA培训核心将通过参与和集成来增强 弗吉尼亚转化卫生研究所（ITHRIV），临床的组成部分 UVA和VT之间的转化科学奖（CTSA）合作伙伴关系以及Wright VCU的临床与转化研究中心（CCTR）。点火的三个主要目标 Kuh NRSA培训核心包括：1）增加博士生，居民（泌尿外科）和 在健康和疾病的基本和翻译方面的博士后研究员使用A 统一的方法； 2）建立一个关注弗吉尼亚州范围内的综合研究培训计划 kuh-diseases; 3）吸引有长期职业的杰出学生和博士后研究员 对IGNITE KUH培训计划的基础或临床研究的兴趣。点燃Kuh Will 优先考虑吸引多个合作伙伴人口不足的学生的策略 机构，包括弗吉尼亚州 - 弗吉尼亚州立大学的三所历史悠久的黑人大学 （VSU），汉普顿大学（HU）和弗吉尼亚联合大学（VUU） - 从而进一步 增强博士研究人员和身体科学家的发展和培训。这 点燃Kuh NRSA培训核心将通过增加教育解决人类健康问题 以及对基础研究中的下一代研究人员和物理科学家的培训或 可以指导和领导未来研究计划的临床科学，旨在减少人类 疾病和kuh特异性领域的苦难。 项目摘要/摘要页面322 联系PD/PI：Okusa，Mark D. NRSA-Training-001（883） 参考 1。JagerKJ，Kovesdy C，Langham R，Rosenberg M，Jha V，ZoccaliC。 沟通范围内有超过8.5亿人患有肾脏疾病。肾脏int 2019; 96：1048-50。 2。StapletonFB，Andreoli S，Ettenger R，Kamil E，Sedman A，ChesneyR。 肾脏科：劳动力对肾脏的劳动力和培训要求的分析 美国儿科肾脏学会委员会。 J Am Soc Nephrol 1997; 8：S5-8。 3。RosnerMH，Berns JS。转化肾脏科。 Clin J Am Soc Nephrol 2018; 13：331-4。 4。DeBoer IH。十字路口的肾脏病。 Clin J Am Soc Nephrol 2018; 13：324。 5。LaneCA，Brown MA。肾脏病：需要复苏的专业？ Hidney INT 2009; 76：594-6。 6。TonelliM，Wiebe N，Manns BJ等。比较不同医学的患者的复杂性 世界医疗保健系统中的专科医生。 JAMA NetW Open 2018; 1：E184852。 7。McKibbenMJ，Kirby EW，Langston J等。在未来20年内投射泌尿外科。 泌尿科2016; 98：21-6。 8。华盛顿SL，第三，巴达拉N，Gaither TW等。联合泌尿外军的种族分布 与普通人群相比。翻译Androl Urol 2018; 7：526-34。 9。WolduSL，Raj GV。手术：外科医生科学家 - 垂死的品种？ Nat Rev Urol 2016; 13：698-9。 10。KeswaniSG，Moles CM，Morowitz M等。学术手术基础科学的未来：确定 外科医生科学家成功的障碍。 Ann Surg 2017; 265：1053-9。 11。HougenHY，Lobo JM，Corey T等。优化和验证新颖的电信的技术基础设施 膀胱镜检查系统。 J Telemed Telecare 2016; 22：397-404。 12。SharmaD，Wallace N，Levinsohn EA等。影响美国成人血液学的趋势和因素 劳动力：一项混合方法研究。 Blood Adv 2019; 3：3550-61。 13。HootsWK，Abkowitz JL，Coller BS，Dimichele DM。为血液学的未来劳动力计划 研究。血液2015; 125：2745-52。 14. soffer e，hoots wk。良性血液学医师科学家劳动力面临的挑战：确定 招聘和保留问题。 Blood Adv 2018; 2：308。 15。PerryHM，Huang L，Ye H等。内皮鞘氨酸1磷酸受体1介导保护和 从急性肾脏损伤中恢复。 J Am Soc Nephrol 2016; 27：3383-93。 16。BajwaA，Huang L，Kurmaeva E等。鞘氨醇激酶2缺乏通过 ifn-gamma。 J Am Soc Nephrol 2016; 28：1145-61。 17。BajwaA，Rosin DL，Chrosicki P等。鞘氨醇1-磷酸受体1增强线粒体 功能并减少顺铂诱导的小管损伤。 J Am Soc Nephrol 2014。 18。BajwaA，Huang L，Ye H等。树突状细胞鞘氨酸1-磷酸受体-3调节Th1-Th2 肾脏缺血再灌注损伤的极性。 J Immunol 2012; 189：2584-96。 19。BajwaA，Jo SK，Ye H等。在近端管中激活鞘氨醇1-磷酸1受体 预防缺血 - 重新灌注损伤。 J Am Soc Nephrol 2010; 21：955-65。 20。JoSK，Bajwa A，Ye H等。鞘氨酸激酶在肾脏缺血再灌注损伤中的发散作用。 Hidney INT 2009; 75：167-75。 21。JoSK，Bajwa A，Awad AS，Lynch KR，Okusa MD。鞘氨醇1-磷酸受体：生物学和 肾脏疾病的治疗潜力。肾脏INT 2008; 73：1220-30。 22. Kao LP，Morad Saf，Davis TS等。化学疗法选择压力改变鞘脂组成和 抗性HL-60细胞中的线粒体生物能。 J Lipid Res 2019; 60：1590-602。 23。GigliottiJC，Huang L，Ye H等。超声检查可通过刺激肾脏缺血再灌注损伤 脾胆碱能抗炎途径。 J Am Soc Nephrol 2013; 24：1451-60。 24。TanakaS，Inoue T，Hossack JA，Okusa MD。非药理学，生物力学方法 急性肾脏损伤的炎症。 Nephron 2017; 137：277-81。 25。GigliottiJC，Huang L，Bajwa A等。超声调节脾神经免疫轴衰减 aki。 J Am Soc Nephrol 2015; 26：2407-81。 26。ChappellJC，Song J，Burke CW，Klibanov AL，Price RJ。有针对性的纳米颗粒携带 超声微泡破坏的成纤维细胞生长因子-2用于热动脉生成。小的 2008; 4：1769-77。 27。AndersonAh，Xie D，Wang X等。糖尿病和非糖尿病CKD进展的新型风险因素： 慢性肾功能不全队列（CRIC）研究的结果。 Am J肾脏DIS 2020。 引用的参考文献第323页