IGNITE KUH NRSA Training Core

IGNITE KUH NRSA 培训核心

• 批准号: 10483193
• 负责人: DIDIER PORTILLA
• 金额: $ 40.4万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10483193
• 关键词: Acute Renal Failure with Renal Papillary Necrosis; Address; Adult; Advocacy; Affect; American; Anti-Cholinergics; Anti-Inflammatory Agents; Area; Attenuated; Basic Science; Benign; Bioenergetics; Biology; Biomechanics; Biomedical Engineering; Blood; Career Choice; Childhood; Chronic Kidney Insufficiency; Cisplatin; Clinical Research; Clinical Sciences; Clinical and Translational Science Awards; Cohort Studies; Communication; Cystoscopy; Data Science; Dendritic Cells; Development; Disease; Doctor of Philosophy; Endothelium; FGF2 gene; Faculty; Future; General Population; Goals; HL-60 Cells; Health; Healthcare Systems; Hematological Disease; Hematology; Historically Black Colleges and Universities; Human; Immunity; Individual; Inflammation; Infrastructure; Injury; Institutes; Institution; Interferon Type II; Kidney; Kidney Diseases; Lead; Lipids; Mediating; Medical; Methods; Microbubbles; Mitochondria; Mole the mammal; National Research Service Awards; Nephrology; Nephrons; Neuroimmune; Operative Surgical Procedures; Pathway interactions; Patients; Physicians; Postdoctoral Fellow; Predictive Analytics; Price; Recovery; Reperfusion Injury; Research; Research Institute; Research Personnel; Research Training; Resistance; Resuscitation; Risk Factors; Role; Scientist; Societies; Sphingolipids; Sphingosine; Sphingosine-1-Phosphate Receptor; Students; Surgeon; System; Systems Biology; Therapeutic; Training; Training Programs; Training and Education; Translational Research; Ultrasonics; Underrepresented Populations; Underrepresented Students; United States; Universities; Urologic Diseases; Urology; Virginia; Washington; chemotherapy; clinical center; cohesion; diabetic; doctoral student; drug discovery; functional genomics; human disease; innovation; kidney fibrosis; medical specialties; nanoparticle delivery; nanotherapeutic; next generation; non-diabetic; novel; pressure; prevent; programs; receptor; recruit; renal ischemia; rosin; sphingosine 1-phosphate; sphingosine kinase; success; targeted delivery; telecare; trend; ultrasound; workforce needs

Contact PD/PI: Okusa, Mark D. NRSA-Training-001 (883) NRSA TRAINING CORE ABSTRACT The Integrated Virginia Research Training Centers in Kidney, Urology and Hematology (IGNITE KUH) training program is being proposed to address an unmet need and major gap in prioritized research training through development and integration of a statewide research program in the Commonwealth of Virginia. The IGNITE KUH NRSA Training Core is an innovative and distinctive multi-institutional, multi-departmental program comprising a team of 65 outstanding faculty from the University of Virginia (UVA), Virginia Commonwealth University (VCU), and Virginia Polytechnic Institute and State University (VT) with primary research programs anchored in the basic research and clinical science of benign KUH diseases in six thematic areas: Systems Biology and Functional Genomics, Immunity and Inflammation, Biomedical Engineering, Nanotherapeutics and Drug Discovery, Clinical and Data Sciences, and Predictive Analytics. The NRSA Training Core leverages existing strengths in kidney and hematological disease research, uniting them with urological disease research in a cohesive, integrated and coordinated research training program. The NRSA Training Core will be enhanced through participation and integration of the Translational Health Research Institute of Virginia (iTHRIV), a component of the Clinical and Translational Science Award (CTSA) partnership between UVA and VT, and the Wright Center for Clinical and Translational Research (CCTR) at VCU. Three major goals of the IGNITE KUH NRSA Training Core include: 1) increase training of PhD students, residents (urology) and postdoctoral fellows in basic and translational aspects of KUH in health and disease using a unified approach; 2) establish an integrated Virginia-wide research training program focused on KUH-diseases; and 3) attract outstanding students and postdoctoral fellows with long-term career interests in basic or clinical research into the IGNITE KUH Training Program. IGNITE KUH will prioritize strategies to attract students from underrepresented populations at several partner institutions, including three historically black universities in Virginia – Virginia State University (VSU), Hampton University (HU), and Virginia Union Universities (VUU) – thereby further enhancing development and training of both PhD researchers and physician scientists. The IGNITE KUH NRSA Training Core will address human health issues through increased education and training of the next generation of researchers and physician scientists in basic research or clinical science who can guide and lead future research programs aiming to lessen human disease and suffering in KUH-specific fields. Project Summary/Abstract Page 322 Contact PD/PI: Okusa, Mark D. NRSA-Training-001 (883) References 1. Jager KJ, Kovesdy C, Langham R, Rosenberg M, Jha V, Zoccali C. A single number for advocacy and communication-worldwide more than 850 million individuals have kidney diseases. Kidney Int 2019;96:1048-50. 2. Stapleton FB, Andreoli S, Ettenger R, Kamil E, Sedman A, Chesney R. Future workforce needs for pediatric nephrology: an analysis of the nephrology workforce and training requirements by the Workforce Committee of the American Society of Pediatric Nephrology. J Am Soc Nephrol 1997;8:S5-8. 3. Rosner MH, Berns JS. Transforming Nephrology. Clin J Am Soc Nephrol 2018;13:331-4. 4. de Boer IH. Nephrology at a Crossroads. Clin J Am Soc Nephrol 2018;13:324. 5. Lane CA, Brown MA. Nephrology: a specialty in need of resuscitation? Kidney Int 2009;76:594-6. 6. Tonelli M, Wiebe N, Manns BJ, et al. Comparison of the Complexity of Patients Seen by Different Medical Subspecialists in a Universal Health Care System. JAMA Netw Open 2018;1:e184852. 7. McKibben MJ, Kirby EW, Langston J, et al. Projecting the Urology Workforce Over the Next 20 Years. Urology 2016;98:21-6. 8. Washington SL, 3rd, Baradaran N, Gaither TW, et al. Racial distribution of urology workforce in United States in comparison to general population. Transl Androl Urol 2018;7:526-34. 9. Woldu SL, Raj GV. Surgery: The surgeon-scientist - a dying breed? Nat Rev Urol 2016;13:698-9. 10. Keswani SG, Moles CM, Morowitz M, et al. The Future of Basic Science in Academic Surgery: Identifying Barriers to Success for Surgeon-scientists. Ann Surg 2017;265:1053-9. 11. Hougen HY, Lobo JM, Corey T, et al. Optimizing and validating the technical infrastructure of a novel tele- cystoscopy system. J Telemed Telecare 2016;22:397-404. 12. Sharma D, Wallace N, Levinsohn EA, et al. Trends and factors affecting the US adult hematology workforce: a mixed methods study. Blood Adv 2019;3:3550-61. 13. Hoots WK, Abkowitz JL, Coller BS, DiMichele DM. Planning for the future workforce in hematology research. Blood 2015;125:2745-52. 14. Soffer E, Hoots WK. Challenges facing the benign hematology physician-scientist workforce: identifying issues of recruitment and retention. Blood Adv 2018;2:308. 15. Perry HM, Huang L, Ye H, et al. Endothelial Sphingosine 1Phosphate Receptor1 Mediates Protection and Recovery from Acute Kidney Injury. J Am Soc Nephrol 2016;27:3383-93. 16. Bajwa A, Huang L, Kurmaeva E, et al. Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN-gamma. J Am Soc Nephrol 2016;28:1145-61. 17. Bajwa A, Rosin DL, Chroscicki P, et al. Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury. J Am Soc Nephrol 2014. 18. Bajwa A, Huang L, Ye H, et al. Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury. J Immunol 2012;189:2584-96. 19. Bajwa A, Jo SK, Ye H, et al. Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury. J Am Soc Nephrol 2010;21:955-65. 20. Jo SK, Bajwa A, Ye H, et al. Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury. Kidney Int 2009;75:167-75. 21. Jo SK, Bajwa A, Awad AS, Lynch KR, Okusa MD. Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney disease. Kidney Int 2008;73:1220-30. 22. Kao LP, Morad SAF, Davis TS, et al. Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells. J Lipid Res 2019;60:1590-602. 23. Gigliotti JC, Huang L, Ye H, et al. Ultrasound prevents renal ischemia-reperfusion injury by stimulating the splenic cholinergic anti-inflammatory pathway. J Am Soc Nephrol 2013;24:1451-60. 24. Tanaka S, Inoue T, Hossack JA, Okusa MD. Nonpharmacological, Biomechanical Approaches to Control Inflammation in Acute Kidney Injury. Nephron 2017;137:277-81. 25. Gigliotti JC, Huang L, Bajwa A, et al. Ultrasound Modulates the Splenic Neuroimmune Axis in Attenuating AKI. J Am Soc Nephrol 2015;26:2407-81. 26. Chappell JC, Song J, Burke CW, Klibanov AL, Price RJ. Targeted delivery of nanoparticles bearing fibroblast growth factor-2 by ultrasonic microbubble destruction for therapeutic arteriogenesis. Small 2008;4:1769-77. 27. Anderson AH, Xie D, Wang X, et al. Novel Risk Factors for Progression of Diabetic and Nondiabetic CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis 2020. References Cited Page 323

联系 PD/PI：Okusa, Mark D.NRSA-Training-001 (883) NRSA 培训核心摘要 弗吉尼亚肾脏、泌尿科和血液学综合研究培训中心 (IGNITE KUH）正在提出培训计划，以解决未满足的需求和优先考虑的重大差距 通过开发和整合全州范围的研究计划进行研究培训 弗吉尼亚联邦。 IGNITE KUH NRSA 培训核心是一种创新且独特的 多机构、多部门项目，由来自 65 名优秀教师组成的团队组成 弗吉尼亚大学 (UVA)、弗吉尼亚联邦大学 (VCU) 和弗吉尼亚大学 理工学院和州立大学 (VT)，主要研究项目设在 良性 KUH 疾病的基础研究和临床科学六个主题领域： 系统 生物学与功能基因组学、免疫与炎症、生物医学工程、 纳米治疗和药物发现、临床和数据科学以及预测分析。这 NRSA 培训核心利用肾脏和血液疾病研究方面的现有优势， 将它们与泌尿系统疾病研究结合起来，进行有凝聚力、综合和协调的研究 培训计划。 NRSA 培训核心将通过参与和整合得到加强 弗吉尼亚转化健康研究所 (iTHRIV) 的成员，该研究所是临床研究的组成部分 UVA 和 VT 以及 Wright 之间的合作伙伴关系和转化科学奖 (CTSA) 弗吉尼亚联邦大学 (VCU) 临床和转化研究中心 (CCTR)。 IGNITE 的三大目标 KUH NRSA 培训核心包括：1) 增加对博士生、住院医生（泌尿科）和 KUH 在健康和疾病方面的基础和转化方面的博士后研究员使用 统一方法； 2）建立一个弗吉尼亚范围内的综合研究培训计划，重点关注 KUH-疾病； 3）吸引具有长期职业生涯的优秀学生和博士后 对 IGNITE KUH 培训计划的基础或临床研究感兴趣。点燃库将 在多个合作伙伴中优先考虑吸引代表性不足人群的学生的策略 机构，包括弗吉尼亚州三所历史悠久的黑人大学——弗吉尼亚州立大学 (VSU)、汉普顿大学 (HU) 和弗吉尼亚联合大学 (VUU) – 从而进一步 加强博士研究人员和医师科学家的发展和培训。这 IGNITE KUH NRSA 培训核心将通过加强教育解决人类健康问题 并培训下一代研究人员和医学科学家进行基础研究或 临床科学谁可以指导和领导未来的研究项目，旨在减少人类 KUH 特定领域的疾病和痛苦。 项目摘要/摘要第 322 页 联系 PD/PI：Okusa, Mark D.NRSA-Training-001 (883) 参考 1. Jager KJ, Kovesdy C, Langham R, Rosenberg M, Jha V, Zoccali C. 一个用于倡导和 全球有超过 8.5 亿人患有肾脏疾病。肾内科 2019；96：1048-50。 2. Stapleton FB、Andreoli S、Ettenger R、Kamil E、Sedman A、Chesney R。儿科未来的劳动力需求 肾脏病学：对肾脏病学劳动力和劳动力培训要求的分析 美国儿科肾脏病学会委员会。 J Am Soc Nephrol 1997；8：S5-8。 3. 罗斯纳 MH，伯恩斯 JS。改变肾脏病学。 Clin J Am Soc Nephrol 2018；13：331-4。 4.德波尔IH。处于十字路口的肾脏病学。 Clin J Am Soc Nephrol 2018；13：324。 5. 加利福尼亚州莱恩，马萨诸塞州布朗。肾内科：需要复苏的专业？肾脏国际 2009；76：594-6。 6. Tonelli M、Wiebe N、Manns BJ 等人。不同医疗机构看诊的患者复杂程度比较 全民医疗保健系统的亚专家。 JAMA 网络公开赛 2018；1：e184852。 7. McKibben MJ、Kirby EW、Langston J 等人。预测未来 20 年的泌尿科劳动力。 泌尿外科 2016 年；98：21-6。 8. Washington SL，第 3，Baradaran N，Gaither TW，等人。美国泌尿外科劳动力的种族分布 各州与一般人口的比较。翻译 Androl Urol 2018；7:526-34。 9. Woldu SL，Raj GV。外科：外科医生科学家——一个垂死的品种？ Nat Rev Urol 2016；13：698-9。 10.Keswani SG、Moles CM、Morowitz M 等人。学术外科基础科学的未来：识别 外科医生科学家成功的障碍。安外科 2017 年；265：1053-9。 11.Hougen HY、Lobo JM、Corey T 等人。优化和验证新型远程通信的技术基础设施 膀胱镜检查系统。 J Telemed Telecare 2016；22：397-404。 12. Sharma D、Wallace N、Levinsohn EA 等人。影响美国成人血液学的趋势和因素 劳动力：一项混合方法研究。血液高级报告 2019；3：3550-61。 13. Hoots WK、Abkowitz JL、Coller BS、DiMichele DM。规划血液学领域的未来劳动力 研究。血液 2015；125：2745-52。 14. 索弗 E，胡茨 WK。良性血液学医师科学家队伍面临的挑战：识别 招聘和保留问题。血液高级报告 2018；2:308。 15. Perry HM，Huang L，Ye H，等。内皮鞘氨醇 1 磷酸受体 1 介导保护和 从急性肾损伤中恢复。 J Am Soc Nephrol 2016；27：3383-93。 16. Bajwa A、Huang L、Kurmaeva E 等。鞘氨醇激酶 2 缺乏可通过以下途径减轻肾脏纤维化 干扰素-γ。 J Am Soc Nephrol 2016；28：1145-61。 17.Bajwa A、Rosin DL、Chroscicki P 等人。鞘氨醇 1-磷酸受体 1 增强线粒体 发挥功能并减少顺铂引起的肾小管损伤。 J Am Soc Nephrol 2014。 18. Bajwa A，Huang L，Ye H，等。树突状细胞鞘氨醇1-磷酸受体3调节Th1-Th2 肾脏缺血再灌注损伤中的极性。免疫学杂志 2012；189：2584-96。 19.Bajwa A、Jo SK、Ye H 等。近曲小管中 1-磷酸鞘氨醇 1 受体的激活 防止缺血再灌注损伤。 J Am Soc Nephrol 2010；21：955-65。 20.Jo SK、Bajwa A、Ye H 等。鞘氨醇激酶在肾脏缺血再灌注损伤中的不同作用。 肾脏国际 2009；75：167-75。 21.Jo SK、Bajwa A、Awad AS、Lynch KR、Okusa MD。 1-磷酸鞘氨醇受体：生物学和 肾脏疾病的治疗潜力。肾脏国际 2008；73：1220-30。 22. Kao LP、Morad SAF、Davis TS 等。化疗选择压力改变鞘脂成分 耐药 HL-60 细胞中的线粒体生物能学。脂质研究杂志 2019；60：1590-602。 23. Gigliotti JC，Huang L，Ye H，等。超声通过刺激肾组织来预防肾缺血再灌注损伤 脾胆碱能抗炎途径。 J Am Soc Nephrol 2013；24：1451-60。 24.Tanaka S、Inoue T、Hossack JA、Okusa MD。非药物、生物力学控制方法 急性肾损伤中的炎症。肾单位 2017；137：277-81。 25. Gigliotti JC、Huang L、Bajwa A 等人。超声调节脾神经免疫轴减弱 急性肾损伤。 J Am Soc Nephrol 2015；26：2407-81。 26. Chappell JC、Song J、Burke CW、Klibanov AL、Price RJ。纳米粒子轴承的靶向递送 通过超声微泡破坏成纤维细胞生长因子-2 用于治疗性动脉生成。小的 2008；4：1769-77。 27. Anderson AH，谢D，王X，等。糖尿病和非糖尿病 CKD 进展的新危险因素： 慢性肾功能不全队列 (CRIC) 研究的结果。 《美国肾脏病杂志》2020 年。 引用的参考文献第 323 页