IGNITE KUH NRSA Training Core

IGNITE KUH NRSA 培训核心

• 批准号: 10652651
• 负责人: DIDIER PORTILLA
• 金额: $ 38.52万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10652651
• 关键词: Acute Renal Failure with Renal Papillary Necrosis; Address; Adult; Advocacy; Affect; American; Anti-Inflammatory Agents; Area; Attenuated; Basic Science; Benign; Bioenergetics; Biology; Biomechanics; Biomedical Engineering; Blood; Breeding; Career Choice; Childhood; Chronic Kidney Insufficiency; Cisplatin; Clinical Research; Clinical Sciences; Clinical and Translational Science Awards; Cohort Studies; Communication; Cystoscopy; Data Science; Dendritic Cells; Development; Disease; Doctor of Philosophy; Endothelium; FGF2 gene; Faculty; Future; General Population; Goals; HL-60 Cells; Health; Healthcare Systems; Hematological Disease; Hematology; Historically Black Colleges and Universities; Human; Immunity; Individual; Inflammation; Infrastructure; Injury; Institution; Interferon Type II; Kidney; Kidney Diseases; Lead; Lipids; Mediating; Medical; Methods; Microbubbles; Mitochondria; Mole the mammal; National Research Service Awards; Nephrology; Nephrons; Neuroimmune; Operative Surgical Procedures; Pathway interactions; Patients; Physicians; Postdoctoral Fellow; Predictive Analytics; Price; Race; Recovery; Reperfusion Injury; Research; Research Institute; Research Personnel; Research Priority; Research Training; Resistance; Resuscitation; Risk Factors; Role; Scientist; Selection for Treatments; Societies; Sphingolipids; Sphingosine; Sphingosine-1-Phosphate Receptor; Students; Surgeon; System; Systems Biology; Therapeutic; Training; Training Programs; Training and Education; Translational Research; Ultrasonics; Underrepresented Populations; Underrepresented Students; United States; Universities; Urologic Diseases; Urology; Virginia; Washington; chemotherapy; cholinergic; clinical center; diabetic; doctoral student; drug discovery; functional genomics; human disease; innovation; kidney fibrosis; medical specialties; nanoparticle delivery; nanotherapeutic; next generation; non-diabetic; novel; pressure; prevent; programs; receptor; recruit; renal ischemia; rosin; sphingosine 1-phosphate; sphingosine kinase; success; targeted delivery; telecare; translational health science; trend; ultrasound; workforce needs

Contact PD/PI: Okusa, Mark D. NRSA-Training-001 (883) NRSA TRAINING CORE ABSTRACT The Integrated Virginia Research Training Centers in Kidney, Urology and Hematology (IGNITE KUH) training program is being proposed to address an unmet need and major gap in prioritized research training through development and integration of a statewide research program in the Commonwealth of Virginia. The IGNITE KUH NRSA Training Core is an innovative and distinctive multi-institutional, multi-departmental program comprising a team of 65 outstanding faculty from the University of Virginia (UVA), Virginia Commonwealth University (VCU), and Virginia Polytechnic Institute and State University (VT) with primary research programs anchored in the basic research and clinical science of benign KUH diseases in six thematic areas: Systems Biology and Functional Genomics, Immunity and Inflammation, Biomedical Engineering, Nanotherapeutics and Drug Discovery, Clinical and Data Sciences, and Predictive Analytics. The NRSA Training Core leverages existing strengths in kidney and hematological disease research, uniting them with urological disease research in a cohesive, integrated and coordinated research training program. The NRSA Training Core will be enhanced through participation and integration of the Translational Health Research Institute of Virginia (iTHRIV), a component of the Clinical and Translational Science Award (CTSA) partnership between UVA and VT, and the Wright Center for Clinical and Translational Research (CCTR) at VCU. Three major goals of the IGNITE KUH NRSA Training Core include: 1) increase training of PhD students, residents (urology) and postdoctoral fellows in basic and translational aspects of KUH in health and disease using a unified approach; 2) establish an integrated Virginia-wide research training program focused on KUH-diseases; and 3) attract outstanding students and postdoctoral fellows with long-term career interests in basic or clinical research into the IGNITE KUH Training Program. IGNITE KUH will prioritize strategies to attract students from underrepresented populations at several partner institutions, including three historically black universities in Virginia – Virginia State University (VSU), Hampton University (HU), and Virginia Union Universities (VUU) – thereby further enhancing development and training of both PhD researchers and physician scientists. The IGNITE KUH NRSA Training Core will address human health issues through increased education and training of the next generation of researchers and physician scientists in basic research or clinical science who can guide and lead future research programs aiming to lessen human disease and suffering in KUH-specific fields. Project Summary/Abstract Page 322 Contact PD/PI: Okusa, Mark D. NRSA-Training-001 (883) References 1. Jager KJ, Kovesdy C, Langham R, Rosenberg M, Jha V, Zoccali C. A single number for advocacy and communication-worldwide more than 850 million individuals have kidney diseases. Kidney Int 2019;96:1048-50. 2. Stapleton FB, Andreoli S, Ettenger R, Kamil E, Sedman A, Chesney R. Future workforce needs for pediatric nephrology: an analysis of the nephrology workforce and training requirements by the Workforce Committee of the American Society of Pediatric Nephrology. J Am Soc Nephrol 1997;8:S5-8. 3. Rosner MH, Berns JS. Transforming Nephrology. 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Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury. J Am Soc Nephrol 2014. 18. Bajwa A, Huang L, Ye H, et al. Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury. J Immunol 2012;189:2584-96. 19. Bajwa A, Jo SK, Ye H, et al. Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury. J Am Soc Nephrol 2010;21:955-65. 20. Jo SK, Bajwa A, Ye H, et al. Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury. Kidney Int 2009;75:167-75. 21. Jo SK, Bajwa A, Awad AS, Lynch KR, Okusa MD. Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney disease. Kidney Int 2008;73:1220-30. 22. Kao LP, Morad SAF, Davis TS, et al. Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells. J Lipid Res 2019;60:1590-602. 23. 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