Data Coordinating Core

数据协调核心 摘要 阻碍脑外伤相关神经变性(趋势)研究的一个关键因素是对 慢性创伤性脑病(CTE)，对更广泛的人群考虑要少得多 颅脑损伤的神经病理效应。事实上，大多数趋势研究工作涉及单一的、本地化的人口 并在单个站点进行；此外，导出的数据在很大程度上无法向更广泛的人提供 社区。在相关的神经退行性疾病如阿尔茨海默氏症和 帕金森氏病，广泛的，协调的，多机构的努力，通过吸引 来自多个人群的数据。为了让TBI研究社区实现这一点，CONNECT-TBI数据 协调核心将专注于建立集中、标准化和可靠的所有 与研究项目有关的数据。通过与行政和智库核心部门的密切互动， 所有神经病理和临床数据的中央储存库将提供给所有授权的 调查人员。此核心旨在实施NINDS建立的公共数据元素(CDE)集 描述本地站点的TBI，并将这些数据汇编到中央数据库中。

Data Coordinating Core SUMMARY A key factor which has hindered research into TBI related neurodegeneration (TReND) is the narrow focus on chronic traumatic encephalopathy (CTE) with far less consideration given to the broader group of neuropathological effects of TBI. Indeed, most TReND research efforts involve a single, localized population and are conducted at a single site; furthermore, the data derived is largely unavailable to the broader community. As has been demonstrated in related neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, broad, coordinated, and multi-institution efforts bolster the quality of research by drawing data from multiple populations. To achieve this for the TBI research community, the CONNECT-TBI Data Coordinating Core will focus its efforts on the establishing central, standardized, and reliable handling of all data relating to the Research Projects. Through close interaction with the Administrative and Brain Bank Core, a central repository of all neuropathological and clinical data will be made available to all authorized investigators. This Core intends to implement the NINDS established sets of Common Data Elements (CDEs) to characterize TBI at local sites and compile these data in the central database.