CE19-001, The Penn Injury Science Center

项目摘要 我们提议宾夕法尼亚大学创伤科学中心（PISC）作为红十字国际委员会在宾夕法尼亚大学的分支机构 通过最高水平的科学、教育和科学， - 开展外联活动，解决风险和保护性暴露在空间的交叉影响， 时间我们的研究范围在地理和时间尺度从广泛的高度颗粒，我们研究 脆弱人口的规模从精确的个人或活动范围内的水平，以广泛的宏观 或政策层面，这取决于所讨论的伤害和暴力情况的性质以及 在伤害科学领域的证据。大多数伤害或暴力事件有多个组成部分的原因。我们 时空透镜帮助我们理解伤害预防科学的复杂性， 理解，以磨练的决定因素和干预点，如果有针对性，将允许 以达到最大的预防伤害效果。我们的时空方法承认， 从来没有意识到一些导致伤害的暴露，即使在确定的 有些风险是无法测量的。但是，通过了解伤病事件的复杂性，我们做得更好。 能够针对最容易改变的风险因素，同样， 最有可能推广。PISC的目标是促进和执行最高质量的研究， 培训，并将科学发现转化为实践和政策，以减少伤害，暴力， 及其在全国范围内的影响，特别是在弱势群体和得不到充分服务的群体中。群体可 由于许多因素，包括他们居住的地方，工作和花费的时间， 他们所扮演的角色，他们所居住的国家的政策，结构性种族主义，以及许多其他因素。因此， 由PISC研究人员领导的伤害预防科学在许多情况下解决了主题和人群 和地理位置。拟建中心围绕4个核心（行政核心、 外展核心、培训和教育核心以及研究核心），并得到内部 外部咨询委员会和社区行动委员会。该中心已提出4个全面发展 研究项目，并将支持探索性赠款计划，以资助试点研究 预防暴力和伤害的优先领域。研究项目包括翻译实施试验 改善阿片类药物使用障碍的温暖交接途径，减少新的机动车碰撞 有执照的司机，应用创新技术减少老年人的福尔斯，并检查十字路口 不良童年经历（ACE）和邻里接触对健康和伤害结果的影响。的 因此，PISC领导层、教师、学员和合作伙伴将合作开展重要研究， 培训和翻译活动，参与宾州社区和地方和国家 在实施和推进一个资金充足、可持续的全面红十字国际委员会方面，

PROJECT SUMMARY We propose the Penn Injury Science Center (PISC) as an ICRC at the University of Pennsylvania (Penn) focusing on the reduction of injuries and violence through the highest caliber science, education, and outreach that addresses the intersecting impacts of risk and protective exposures across space and time. Our research ranges in geographic and temporal scale from broad to highly granular, and we study vulnerable populations at scales ranging from a precise within-person or within-activity level to a broad macro or policy level depending on the nature of the injury and violence scenario that is at issue and the state of evidence in that area of injury science. Most injury or violence events have multiple component causes. Our space-time lens helps us appreciate the complexity of injury prevention science and use that understanding to hone in on the determinants and points of intervention that, if targeted, would allow us to achieve the greatest injury prevention impact. Our space-time approach acknowledges that we may never be aware of some of the exposures that contribute to cause an injury and that, even among identified exposures, some may not be measureable. But, by appreciating the complexity of injury events, we are better able to target the risk factors that are the most amenable to change and, likewise, the protective factors that are most feasible to promote. The goal of the PISC is to promote and perform the highest quality research, training, and translation of scientific discoveries into practice and policy, in order to reduce injuries, violence, and their impact nationwide, particularly among vulnerable and underserved populations. Populations may be vulnerable or underserved due to many factors, including the places they live, work and spend time, sports they play, the policies of the state where they live, structural racism, and many other factors. Hence the focus of the injury prevention science led by PISC investigators addresses topics and populations in many contexts and geographic locations. The proposed Center is organized around 4 Cores (the Administrative Core, the Outreach Core, the Training and Education Core, and the Research Core) with support and input from Internal and External Advisory Boards, and a Community Action Board. The Center has proposed 4 fully developed Research Projects in this application and will support an Exploratory Grant Program to fund pilot research in injury and violence prevention priority areas. The Research Projects include a translational implementation trial towards improving warm handoff pathways for opioid use disorder, reducing motor vehicle crashes in newly licensed drivers, applying innovative technology to reduce falls in older adults, and examining the intersection of adverse childhood experiences (ACEs) and neighborhood exposures on health and injury outcomes. The PISC leadership, faculty, trainees, and partners, thus, will collaborate to conduct important research, training, and translation activities that engage the Penn community and local and national stakeholders in implementing and advancing a fully funded and sustainable comprehensive ICRC.