Data Coordinating Core

数据协调核心

• 批准号: 10024095
• 负责人: DOUGLAS J WIEBE
• 金额: $ 16.95万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10024095
• 关键词: Age; Alzheimer' s Disease; Brain; Clinical Data; Clinical assessments; Collaborations; Common Data Element; Communities; Data; Data Analyses; Data Element; Data Linkages; Data Reporting; Development; Informatics; Injury; Institution; Laboratories; Link; Mind; National Institute of Neurological Disorders and Stroke; Nerve Degeneration; Neurodegenerative Disorders; Parkinson Disease; Phase; Population; Recovery; Research; Research Personnel; Research Project Grants; Severities; Site; Standardization; System; Traumatic Brain Injury; central database; chronic traumatic encephalopathy; data archive; data infrastructure; data sharing; data warehouse; design; digital; patient population; repository; response

Data Coordinating Core SUMMARY A key factor which has hindered research into TBI related neurodegeneration (TReND) is the narrow focus on chronic traumatic encephalopathy (CTE) with far less consideration given to the broader group of neuropathological effects of TBI. Indeed, most TReND research efforts involve a single, localized population and are conducted at a single site; furthermore, the data derived is largely unavailable to the broader community. As has been demonstrated in related neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, broad, coordinated, and multi-institution efforts bolster the quality of research by drawing data from multiple populations. To achieve this for the TBI research community, the CONNECT-TBI Data Coordinating Core will focus its efforts on the establishing central, standardized, and reliable handling of all data relating to the Research Projects. Through close interaction with the Administrative and Brain Bank Core, a central repository of all neuropathological and clinical data will be made available to all authorized investigators. This Core intends to implement the NINDS established sets of Common Data Elements (CDEs) to characterize TBI at local sites and compile these data in the central database.

数据协调核心 总结 阻碍TBI相关神经变性（TReND）研究的一个关键因素是对TBI相关神经变性的狭隘关注。 慢性创伤性脑病（CTE），对更广泛的 TBI的神经病理学影响。事实上，大多数TReND研究工作都涉及单一的局部人群， 并且在一个站点进行;此外，所获得的数据在很大程度上无法提供给更广泛的 社区正如在相关的神经退行性疾病如阿尔茨海默病和阿尔茨海默病中所证明的那样， 帕金森氏病，广泛，协调，多机构的努力，通过绘制提高研究质量 来自多个人群的数据。为了实现这一目标的TBI研究社区，连接TBI数据 协调核心将集中精力建立中央，标准化和可靠的处理所有 与研究项目有关的数据。通过与行政和人才库核心的密切互动， 所有神经病理学和临床数据的中央储存库将提供给所有授权的 investigators.该核心旨在实现NINDS建立的通用数据元素（CDE）集 描述当地研究中心的TBI特征，并在中央数据库中汇编这些数据。