Determine how telomere dysfunction impacts neuronal function

确定端粒功能障碍如何影响神经元功能

• 批准号: 10486996
• 负责人: Eros Lazzerini Denchi
• 金额: $ 63.92万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10486996
• 关键词: Address; Adult; Affect; Anatomy; Animals; Anxiety; Architecture; Biological Models; Biology; Brain; Cells; Child; Clinical; Clinical Research; Cutaneous; DNA Damage; Development; Disease; Dyskeratosis Congenita; Functional disorder; Genes; Genetic Diseases; Genetic Models; Growth; Health; Hereditary Disease; Human; Immunologic Deficiency Syndromes; Impairment; Intellectual functioning disability; Knock-out; Laboratories; Learning; Length; Lesion; Leukoplakia; Longevity; Malignant Neoplasms; Memory Loss; Mitotic; Molecular; Molecular Biology; Mus; Mutation; Nail plate; Neuraxis; Neurons; Nonhomologous DNA End Joining; Pancytopenia; Pathway interactions; Phase; Play; Process; Psychoses; PubMed; Publishing; Role; Seizures; Syndrome; System; TP53 gene; Telomere Maintenance; Testing; Work; chromosome fusion; cognitive capacity; conditional knockout; dentate gyrus; embryonic stem cell; experimental study; genetic approach; granule cell; insight; mouse genetics; mouse model; nerve stem cell; nestin protein; neurogenesis; neuron loss; novel; progenitor; response; telomere

Having started my laboratory at NCI in late May 2018 I have been mainly involved in setting up my laboratory. I am currently waiting for the transfer of animals to start this project here at NCI. In my previous laboratory, we have initiated this project and published our initial observation in genes and development: Lobanova A, She R, Pieraut S, Clapp C, Maximov A, Denchi EL. Different requirements of functional telomeres in neural stem cells and terminally differentiated neurons. Genes & development. 2017;31(7):639-47. Epub 2017/04/22. doi: 10.1101/gad.295402.116. PubMed PMID: 28428263; PubMed Central PMCID: PMC5411705.

2018 年 5 月下旬在 NCI 开始我的实验室后，我主要参与了实验室的建立。我目前正在等待动物转移，以便在 NCI 开始这个项目。在我以前的实验室中，我们发起了这个项目并发表了我们在基因和发育方面的初步观察结果：Lobanova A, She R, Pieraut S, Clapp C, Maximov A, Denchi EL。神经干细胞和终末分化神经元对功能端粒的不同要求。基因与发育。 2017；31(7):639-47。电子版 2017/04/22。 doi：10.1101/gad.295402.116。 PubMed PMID：28428263； PubMed 中心 PMCID：PMC5411705。