TRF2 INTERACTING PROTEINS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 TRF2是一种定位于端粒的必需基因，是染色体末端保护所必需的。TRF2与双链端粒重复序列(TTAGGG)结合，是招募额外因子所需的锚定蛋白。最近的数据表明，超过200种蛋白质结合在端粒上。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. TRF2 is an essential gene that localizes to telomeres and is required for chromosome end protection. TRF2 binds to double stranded telomeric repeats (TTAGGG) and serves as an anchoring protein required to recruit additional factors. Recent data suggest that over 200 proteins are bound at telomeres.