TRF2 INTERACTING PROTEINS

TRF2 相互作用蛋白

• 批准号: 8365840
• 负责人: Eros Lazzerini Denchi
• 金额: $ 1.28万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365840
• 关键词: Binding; Biology; Chromosomes; Data; Essential Genes; Funding; Fungal Genome; Grant; National Center for Research Resources; Principal Investigator; Protein Binding; Proteins; Recruitment Activity; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; cost; telomere

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. TRF2 is an essential gene that localizes to telomeres and is required for chromosome end protection. TRF2 binds to double stranded telomeric repeats (TTAGGG) and serves as an anchoring protein required to recruit additional factors. Recent data suggest that over 200 proteins are bound at telomeres.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， NCRR赠款不直接向子项目或子项目工作人员提供资金。 TRF 2是定位于端粒的必需基因，并且是染色体末端保护所必需的。TRF 2与双链端粒重复序列（TTAGGG）结合，并作为招募额外因子所需的锚定蛋白。最近的数据表明，超过200种蛋白质与端粒结合。