Validity and Utility of a PATCH to Monitor Free-living Energy Expenditure in Children 3 to 8 Years Old

监测 3 至 8 岁儿童自由生活能量消耗的补丁的有效性和实用性

• 批准号: 10488284
• 负责人: Bridget R. Armstrong
• 金额: $ 17.89万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10488284
• 关键词: 8 year old; Acceleration; Accelerometer; Age; Assessment tool; Behavior; Cardiovascular Diseases; Caring; Chest; Child; Child Health; Complex; Data; Development; Device Designs; Devices; Diabetes Mellitus; Electrocardiogram; Energy Metabolism; Epidemiology; Equation; Evaluation; Goals; Health; Heart Rate; Hour; Human body; Indirect Calorimetry; Individual; Intervention; Intervention Studies; Laboratories; Link; Longevity; Maintenance; Measurement; Measures; Methodology; Methods; Mind; Monitor; Movement; Nature; Obesity; Observational Study; Outcome; Phase; Photoplethysmography; Physical activity; Physical assessment; Polysomnography; Postage Stamps; Prevention; Protocols documentation; Research; Resistance; Series; Signal Transduction; Skin; Sleep; Technology; Testing; Time; Water; acceptability and feasibility; base; design; energy balance; epidemiology study; fitbit; free behavior; improved; innovation; novel; open source; sedentary; sensor; validation studies; wearable device

Accurate assessment of physical activity energy expenditure is essential to (1) quantify the relationships between energy expenditure and children’s health outcomes and (2) assess intervention/prevention effects. However, energy expenditure is difficult to assess in free-living conditions. A combination of heart rate (HR) and accelerometry data provides a more precise estimate of energy expenditure than either HR or accelerometry alone, when compared to a criterion measure of direct or indirect calorimetry. However, very few available devices exist which capture both HR and accelerometry. Although some scientific- grade (e.g., ActiHeart) and consumer-grade wearable devices (e.g., Fitbit) incorporate multiple sensors (i.e. accelerometry and HR via chest leads or photoplethysmography), restrictions to raw signal data (FitBit) or the need to change chest leads daily (ActiHeart) makes it problematic to use such devices to measure energy expenditure in children. Moreover, these devices were not developed with children in mind, and therefore, have limitations regarding size, comfort, and the need for daily care/maintenance. The current study leverages microcontroller wearable electronics’ technology to develop a small device that adheres to the human body (referred to here as the ‘PATCH’). The PATCH is the size of a postage stamp and incorporates multiple sensors (i.e. accelerometry and photoplethysmography) in a single device. Using multiple channels of raw signal data, we can more accurately estimate energy expenditure under free-living conditions. The PATCH is far less obtrusive than existing scientific grade integrated devices (i.e., ActiHeart) or commercial wearable devices (i.e., FitBit), and thus has the potential to improve acceptability and wear-time, particularly among children. Our long-term goal is to advance the measurement field for epidemiologic- and intervention- based studies that focus on measuring 24-hour movement and energy expenditure. The objectives of the proposed project are to conduct a series of studies that include both laboratory and field- based protocols to establish the preliminary reliability, validity and utility/feasibility of the new PATCH technology for measuring children’s energy expenditure in free-living conditions. We will evaluate the validity of the PATCH to measure physical activity and HR of children (age 3-8 years old) compared to criterion measures of accelerometry and electrocardiography, respectively. We will develop equations to predict energy expenditure and examine initial concordance compared to indirect calorimetry. Using quantitative and qualitative methodology, we will also assess the feasibility and acceptability of wearing the PATCH over extended periods of monitoring wear time (e.g., 30 days). This technology has the potential to become a research standard for intervention and epidemiological studies of energy expenditure among children. Results from the current study will inform the next phase of development for wearable devices to measure the energy expenditure of free-living individuals.

准确评估身体活动能量消耗对于（1）量化 能量消耗和儿童的健康结果和（2）评估干预/预防效果。然而，在这方面， 在自由生活条件下，能量消耗很难评估。心率（HR）和 加速度计数据提供比HR或加速度计更精确的能量消耗估计 单独，当与直接或间接量热法的标准测量相比时。 然而，很少存在捕获HR和加速度测量两者的可用设备。尽管一些科学- 等级（例如，ActiHeart）和消费级可穿戴设备（例如，Fitbit）结合多个传感器（即 通过胸导联或光电体积描记术进行的加速测量和HR）、对原始信号数据的限制（FitBit）或 需要每天更换胸导联（ActiHeart）使得使用这样的设备来测量能量成为问题 孩子的支出。此外，这些设备不是为儿童开发的，因此， 关于尺寸、舒适度和日常护理/维护的需要的限制。 目前的研究利用微控制器可穿戴电子技术开发了一种小型设备， 粘附在人体上（这里称为“贴片”）。补丁是邮票的大小， 将多个传感器（即，加速度计和光电体积描记术）合并在单个设备中。使用多个 原始信号数据的通道，我们可以更准确地估计自由生活条件下的能量消耗。 PATCH远不如现有的科学级集成设备（即，ActiHeart）或商业 可穿戴设备（即，FitBit），因此具有改善可接受性和佩戴时间的潜力，特别是 在儿童中。我们的长期目标是推进流行病学和干预的测量领域， 基于研究，专注于测量24小时运动和能量消耗。 拟议项目的目标是进行一系列研究，包括实验室和实地研究- 的协议，以建立新的PATCH技术的初步可靠性，有效性和实用性/可行性 用于测量儿童在自由生活条件下的能量消耗。我们将评估补丁的有效性 测量儿童（3-8岁）的体力活动和HR，与标准测量值进行比较， 加速度计和心电图。我们将建立方程来预测能量消耗 并检查与间接量热法相比的初始一致性。使用定量和定性 方法，我们还将评估长期佩戴修补片的可行性和可接受性 监测磨损时间（例如，30天）。这项技术有可能成为一种研究标准， 儿童能量消耗干预和流行病学研究。当前研究的结果 将为可穿戴设备的下一阶段开发提供信息，以测量自由生活的能量消耗。 个体