Public Drinking Water Contaminants and Infant Health: Advancing Environmental Justice

公共饮用水污染物和婴儿健康：促进环境正义

• 批准号: 10488610
• 负责人: Anne E Nigra
• 金额: $ 40.5万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-14 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10488610
• 关键词: American Indians; Arsenic; Automobile Driving; Award; Biological Markers; Birth; Birth Records; California; Case Study; Child Health; Cities; Collaborations; Communities; County; Data; Databases; Development; Disinfection; Dose; Environmental Health; Epidemiologist; Epidemiology; Ethnic Origin; Evidence based intervention; Exhibits; Exposure to; Funding; Gestational Age; Health; Hispanic; Imprisonment; Inequality; Infant; Infant Health; Journals; Lead; Link; Longevity; Low Birth Weight Infant; Maps; Measures; Metal exposure; Metals; Modeling; Monitor; Multiple Birth Offspring; Outcome; Participant; Peer Review; Plant Roots; Policies; Positioning Attribute; Pregnancy; Premature Birth; Productivity; Public Health Schools; Publications; Race; Radioisotopes; Reduce health disparities; Regulation; Research; Research Personnel; Small for Gestational Age Infant; Socioeconomic Status; Strategic Planning; Structural Racism; Subgroup; System; United States; United States Environmental Protection Agency; United States National Institutes of Health; Universities; Water; Water Pollutants; adverse birth outcomes; career; career development; classism; cohort; data repository; drinking water; effectiveness evaluation; environmental justice; epidemiology study; health disparity; improved; in utero; innovation; microbial; novel; prenatal exposure; primary outcome; professor; programs; public drinking; public health intervention; racial and ethnic; racial and ethnic disparities; racial disparity; racial diversity; recruit; rural Americans; secondary outcome; socioeconomic disparity; socioeconomics; tenure track; urinary

Project Summary The objective of this project is to evaluate the contribution of racial/ethnic and socioeconomic inequalities in public drinking water contaminant exposures to in utero water contaminant exposures and subsequent adverse birth outcomes across the United States (US). Potential disparities in public drinking water contaminant exposures have not been comprehensively characterized across the US. Such disparities in public drinking water contaminant exposures may directly contribute to inequalities in in utero exposures and inequalities in adverse birth outcomes. This proposal aims to (1) evaluate racial/ethnic and socioeconomic inequalities in drinking water contaminant exposures across the US by developing novel nationwide public drinking water contaminant exposure estimates for over eighty regulated contaminants; (2) evaluate the contribution of estimated public drinking water metal exposures to measured in utero internal dose and infant health outcomes across three diverse birth cohorts; and (3) evaluate the impact of changes in national public drinking water regulations on infant health outcomes using a difference-in-differences approach, which can characterize the impact of federal drinking water regulatory changes on diverse racial/ethnic and socioeconomic subgroups in the US. In Aim 1, novel nationwide public drinking water contaminant exposure estimates will be derived primarily using data from the US Environmental Protection Agency's Six Year Review of Contaminant Occurrence database, which contains compliance monitoring data for over 95% of public drinking water systems throughout the US. In Aim 2, novel public drinking water contaminant exposure estimates from Aim 1 are assigned to maternal-infant dyads in several diverse birth cohorts in the Environmental influences on Child Health Outcomes (ECHO) nationwide consortium, a pioneering NIH funded consortium. In Aim 3, novel public drinking water contaminant exposure estimates from Aim 1 are assigned to birth records from the California Comprehensive Birth File to evaluate the impact of reducing water contaminant exposures (via federal regulatory change) on adverse birth outcomes. The proposed study responds directly to the NIH Strategic Plan 2020 aim to “Develop evidence- based interventions to reduce health disparities,” including “Understanding mechanisms that lead to health disparities by race/ethnicity and socioeconomic status.”

项目概要 该项目的目标是评估种族/族裔和社会经济不平等的影响 公共饮用水污染物暴露 子宫内水污染物暴露以及随后的不利影响 美国 (US) 各地的出生结果。公共饮用水污染物的潜在差异 美国各地的风险敞口尚未得到全面描述。公共饮酒方面的这种差异 水污染物暴露可能直接导致子宫内暴露和出生后暴露的不平等 不良的分娩结果。 该提案旨在 (1) 评估饮用水污染物中的种族/民族和社会经济不平等 通过开发新型全国性公共饮用水污染物暴露方案，在美国各地进行暴露 对八十多种受管制污染物的估计； (2)评估估计公众饮酒的贡献 三种不同的子宫内剂量测量的水金属暴露和婴儿健康结果 出生队列； (3) 评估国家公共饮用水法规变化对婴儿的影响 使用双重差异方法来衡量健康结果，该方法可以描述联邦的影响 美国不同种族/民族和社会经济群体的饮用水监管变化。在目标 1 中， 将主要使用数据得出新的全国公共饮用水污染物暴露估计值 来自美国环境保护署污染物发生情况六年回顾数据库，其中 包含全美 95% 以上的公共饮用水系统的合规性监测数据。瞄准 2、目标 1 中的新型公共饮用水污染物暴露估计分配给母婴 环境对儿童健康结果的影响 (ECHO) 中几个不同出生队列的二元组 全国性财团，一个由美国国立卫生研究院 (NIH) 资助的先驱财团。在目标 3 中，新型公共饮用水污染物 将目标 1 的暴露估计值分配给加州综合出生档案中的出生记录，以 评估减少水污染物暴露（通过联邦监管变化）对不良分娩的影响 结果。拟议的研究直接响应 NIH 2020 年战略计划的目标，即“开发证据- 减少健康差距的干预措施，”包括“了解导致健康的机制 种族/族裔和社会经济地位的差异。”