Novel high-field MRI compatible subdural electrode and acquisition system for recording and stimulation in small animals

新型高场 MRI 兼容硬膜下电极和采集系统，用于小动物的记录和刺激

• 批准号: 10487530
• 负责人: Hernan Millan
• 金额: $ 10.83万
• 依托单位: EMRI SYSTEMS LLP
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-13 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10487530
• 关键词: Adhesions; Animal Experimentation; Animal Model; Animals; Area; Boston; Brain; Brain imaging; Clinical; Data; Disease; Drug abuse; Electrocorticogram; Electrodes; Electroencephalogram; Electroencephalography; Electromyography; Electrophysiology (science); Engineering; Epilepsy; Exposure to; Film; Fruit; Functional Magnetic Resonance Imaging; Gelfilm; General Hospitals; Genetic; Goals; Human; Image; Imaging Device; Implant; Lead; Legal patent; Magnetic Resonance Imaging; Massachusetts; Medicine; Miniaturization; Mission; Modification; Multimodal Imaging; Neurosciences; Patients; Performance; Phase; Polymers; Primates; Property; Publications; Rattus; Research; Safety; Stretching; Surface; System; Testing; Thick; Thinness; Tissues; Work; addiction; animal imaging; base; clinically significant; commercialization; data quality; flexibility; imaging approach; imaging study; imaging system; improved; innovation; nerve injury; neurosurgery; nonhuman primate; novel; open source; pre-clinical; prototype; relating to nervous system; source localization; tool

Abstract Preclinical small animal imaging makes valuable contributions to improving our understanding of human brain. Multi-modal imaging approaches to combine functional Magnetic Resonance Imaging (fMRI) with Intracranial Electroencephalogram (iEEG) provides an unparalleled view of the global network activity across cortical areas, revealing information at high temporal and spatial scales about functional connectivity and their intrinsic oscillatory properties, which is of vital importance in many branches of neuroscience and medicine. Despite this clear advantage, the use of iEEG-fMRI is limited in small animal research. The existing MRI compatible headstages on the market for small animals are inadequate to acquire high-fidelity iEEG-fMRI. Working within this premise, the long-term goal of this project is to develop a headstage for high-fidelity recording and stimulation in small animals. We propose to unlock high-fidelity iEEG-fMRI imaging paradigm leveraging our patented innovative MRI-compatible electrode- grid (PTFOS) which is based on organic-absorbable, stretchable, and conformable substrate for optimal safety, flexibility and performance with distinct advantages over other neural grids. Phase I of this application proposes to develop HF-2 acquisition prototype which will fit into animal MRI bore recording constraints and tests its feasibility in rats during high-field MRI (9.4Tesla) at Massachusetts General Hospital. Phase II focuses on adding stimulation module, commercialization and miniaturization of HF-2 into a tiny headstage.

抽象的 临床前小动物成像为改进做出了宝贵的贡献 我们对人脑的理解。多模式成像方法结合 具有颅内的功能磁共振成像（fMRI） 脑电图（IEEG）提供了全局网络的无与伦比的视图 跨皮质区域的活动，在高时空和空间上揭示信息 有关功能连通性及其内在振荡特性的尺度， 在神经科学和医学的许多分支中至关重要。尽管如此 明显的优势，在小型动物研究中，使用IEEG-FMRI受到限制。这 小型动物市场上现有的MRI兼容媒体是 不足以获得高保真IEEG-FMRI。在这个前提中工作， 该项目的长期目标是为高保真记录开发媒体 和刺激小动物。我们建议解锁高保真IEEG-FMRI 利用我们专利的创新MRI兼容电极的成像范式 - 网格（PTFO）基于有机可吸收，可拉伸和符合 具有明显优势的最佳安全性，灵活性和性能的底物 在其他神经网格上。该应用程序的第一阶段建议开发HF-2 采集原型，该原型适合动物MRI孔记录约束和 在马萨诸塞州的高场MRI（9.4Tesla）期间测试其在大鼠中的可行性 综合医院。第二阶段的重点是添加刺激模块， HF-2的商业化和小型化成一个小型的媒体。