Novel high-field MRI compatible subdural electrode and acquisition system for recording and stimulation in small animals

摘要 临床前小动物成像为改善 我们对人脑的理解多模态成像方法用于联合收割机 脑功能磁共振成像（fMRI） 脑电图（iEEG）提供了一个无与伦比的全球网络视图 大脑皮层区域的活动，揭示了高时空信息 关于功能连接性及其内在振荡特性的尺度， 在神经科学和医学的许多分支中至关重要。尽管如此 虽然iEEG-fMRI的优势明显，但其在小动物研究中的应用有限。的 市场上现有的用于小动物的MRI兼容头台 不足以获得高保真iEEG-fMRI。在这个前提下， 这个项目的长期目标是开发一个高保真录音的头台 和小动物的刺激。我们建议解锁高保真iEEG-fMRI 利用我们的专利创新MRI兼容电极的成像范例- 网格（PTFOS），基于有机可吸收，可拉伸和顺应性 具有独特优势的最佳安全性、灵活性和性能的基材 其他的神经网络。该申请的第一阶段建议开发HF-2 采集原型，将适合动物MRI孔记录限制， 在马萨诸塞州的高场MRI（9.4特斯拉）中测试其在大鼠中的可行性 综合医院第二阶段的重点是增加刺激模块， HF-2的商业化和小型化到一个微小的云台。

Abstract Preclinical small animal imaging makes valuable contributions to improving our understanding of human brain. Multi-modal imaging approaches to combine functional Magnetic Resonance Imaging (fMRI) with Intracranial Electroencephalogram (iEEG) provides an unparalleled view of the global network activity across cortical areas, revealing information at high temporal and spatial scales about functional connectivity and their intrinsic oscillatory properties, which is of vital importance in many branches of neuroscience and medicine. Despite this clear advantage, the use of iEEG-fMRI is limited in small animal research. The existing MRI compatible headstages on the market for small animals are inadequate to acquire high-fidelity iEEG-fMRI. Working within this premise, the long-term goal of this project is to develop a headstage for high-fidelity recording and stimulation in small animals. We propose to unlock high-fidelity iEEG-fMRI imaging paradigm leveraging our patented innovative MRI-compatible electrode- grid (PTFOS) which is based on organic-absorbable, stretchable, and conformable substrate for optimal safety, flexibility and performance with distinct advantages over other neural grids. Phase I of this application proposes to develop HF-2 acquisition prototype which will fit into animal MRI bore recording constraints and tests its feasibility in rats during high-field MRI (9.4Tesla) at Massachusetts General Hospital. Phase II focuses on adding stimulation module, commercialization and miniaturization of HF-2 into a tiny headstage.