Episodic Future Thinking to Improve Management of Type 2 Diabetes in Rural and Urban Patients: Remote Delivery and Outcomes Assessment to Increase Reach and Dissemination

改善农村和城市患者 2 型糖尿病管理的情景未来思考：远程交付和结果评估以扩大覆盖范围和传播

• 批准号: 10488205
• 负责人: Jeffrey Scott Stein
• 金额: $ 32.75万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-12 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10488205
• 关键词: Adherence; Behavior; Behavioral; Body Weight decreased; Caloric Restriction; Clinical; Clinical Trials; Complications of Diabetes Mellitus; Consumption; Data; Development; Diabetic Retinopathy; Diet; Dimensions; Disease; Disease Management; Disease Progression; Event; Feedback; Food; Future; Geography; Glycosylated hemoglobin A; Goals; Health Benefit; Health Personnel; Health Services Accessibility; Health behavior; Individual; Intervention; Interview; Kidney Diseases; Knowledge; Laboratories; Life Style; Measures; Mediating; Methods; Mission; Morbidity - disease rate; National Institute of Diabetes and Digestive and Kidney Diseases; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Outcome Assessment; Outcome Measure; Outcome Study; Participant; Patients; Pharmaceutical Preparations; Phase; Physical activity; Prediabetes syndrome; Psyche structure; Research; Rural; Rural Population; Structure; Thinking; Time; Urban Population; Weight; Weights and Measures; Work; base; collaborative care; cost; design; diabetes education; diabetes management; diet and exercise; dietary; discounting; disorder risk; efficacy evaluation; glycemic control; healthy lifestyle; improved; intervention effect; medication compliance; mortality; obesogenic; patient population; post intervention; prevent; primary outcome; prospective; remote assessment; remote delivery; remote intervention; response; rural patients; simulation; smartphone Application; therapeutic target; treatment adherence; two-dimensional; urban disparity; week trial

PROJECT SUMMARY Successful management of type 2 diabetes (T2D) requires adherence to a dietary, physical activity, and medication plan agreed upon between a patient and their healthcare providers. The lifestyle changes involved in these collaborative care plans often provide little to no short-term benefit and may instead be aversive (e.g., caloric restriction and physical activity). However, these changes provide critical health benefits in the future, allowing patients with T2D to halt or reverse disease progression and avoid T2D-related complications (e.g., renal disease or diabetic retinopathy). Thus, successful management of type 2 diabetes requires one's present behavior to be guided by future outcomes. Unfortunately, accumulating evidence indicates that individuals with type 2 diabetes and those at risk for this disorder show elevated rates of delay discounting (i.e., devaluation of delayed consequences), which prior data suggest contribute to development and progression of T2D. Thus, interventions shown to increase valuation of the future are likely to improve T2D management. One such intervention is episodic future thinking (EFT), a form of prospection in which participants vividly imagine events that might occur in their future. Preliminary data from the investigative team suggests that EFT facilitates weight loss and improves glycemic control in patients with T2D. In the proposed work, we will adapt these methods to examine the feasibility of both remote delivery of EFT and remote outcomes assessment (e.g., weight loss, glycemic control, and delay discounting) in geographically distributed urban and rural participants. Because remote delivery and assessment minimize both participant and experimenter burden, these methods may increase the reach, dissemination, and impact of the intervention. Specific Aim 1 will examine the 8- and 24- week efficacy of remotely delivered EFT in patients with T2D on remote measures of weight loss, glycemic control, and delay discounting. Secondary measures will include dietary recalls, physical activity, and medication adherence. Participants will generate vivid, episodic events and be prompted via a guided smartphone app for 24 weeks to engage in EFT or a control condition in their daily lives. All participants (EFT and control control) will receive diet and physical activity support, individualized for patients' collaborative care plans. Sub-aim 1a will compare outcome measures between urban and rural populations to evaluate whether EFT's efficacy is robust against rural-urban disparities. Specific Aim 2 will examine the acceptability of remote EFT. For an intervention to be effective in clinical settings, it should be easy to use and its helpfulness should be apparent to patients. Thus, participants will rate the EFT or control conditions along two dimensions of acceptability: perceived helpfulness and ease of use. Participants will also complete brief, semi-structured interviews during a post-intervention debriefing phase to provide feedback regarding perceived strengths, as well as possible barriers and limitations, of the intervention.

项目总结