A novel, comprehensive approach to post-stroke gait rehabilitation

点击翻译按钮获取中文摘要

Information from PI-Prime Award PROJECT SUMMARY The goal of this project is to determine the feasibility and optimal parameters of a novel, comprehensive approach to gait training in individuals with chronic stroke. Current post-stroke gait training interventions follow into two distinct approaches that target different domains of gait dysfunction (as defined by the International Classification of Functioning, Health, and Disability). Biofeedback-based training is typically employed to treat walking pattern impairments (e.g., kinematic deviations relative to able-bodied controls). Whereas, aerobic exercise intensity-based training is the current gold-standard to treat walking activity limitations (e.g., slow walking speeds). Here, we propose to test the impact of combining these approaches into a single intervention to work toward the development of a more effective, comprehensive, carefully crafted approach to gait rehabilitation or persons post-stroke. The central hypothesis is that individuals with chronic stroke have the capacity to use biofeedback to reduce kinematic gait deviations while walking at a range of recommended aerobic intensity levels. Aim 1 will identify the gait biofeedback variable that elicits the largest reduction in interlimb asymmetry in persons post-stroke. Aim 2 will determine the capacity for persons post-stroke to reduce their interlimb asymmetry while walking at three different levels of aerobic intensity. Participants with chronic stroke in Aims 1 will each complete in three experimental sessions and participants in Aim 2 will complete 1 experimental session. Biomechanical analyses and physiologic assessments will be used across both aims to test our working hypotheses. We expect to show that biofeedback of paretic propulsion leads to the greatest reduction in interlimb asymmetry post-stroke and that participants have the capacity to make biofeedback-driven interlimb asymmetry reductions in all three aerobic intensities, but the magnitude of reduction will be the largest at a moderate aerobic walking intensity. The proposed work is innovative because it will be the first to test the relative effects of providing biofeedback of different gait variables on whole lower extremity kinematics in persons post-stroke and test a novel combination of two well-established gait training methods (biofeedback- and intensity-based training) for neurologic patient populations. This is a critical next step in moving the post-stroke gait rehabilitation field forward. The results are expected to have a high impact because it will provide foundational evidence to support a subsequent R01 proposal aimed to assess the long- term learning effects and potential mechanisms of action of a combinatory post-stroke gait rehabilitation approach. If successful, this line of work stands to significantly improve the current standard of care in gait rehabilitation post-stroke.