Atlanta Center for Microsystems Engineered Point-of-Care Technologies (ACME POCT)

护理点（POC）诊断能力的出现使得能够在临床上进行快速和及时的临床评价。 医生的办公室，救护车，家庭，现场，或在医院，并有可能显着 影响卫生保健提供。在心脏病学、肺病学/重症监护和血液学中，POC检测起着重要作用。 特别重要的作用，因为心脏和肺是需要真实的时间的最重要的器官之一 诊断和快速管理期间的严重疾病，而血液中的病理变化是相关的 严重的全身性疾病一类新型医疗技术正在显示出POC的前景 应用是微系统工程技术，也就是说，微芯片使能的设备范围从 微机电系统（MEMS）为基础的传感器，微流体，甚至智能手机为基础的系统。 基于微芯片的系统以其小尺寸和功率要求而著称， 对于POC测试至关重要。此外，微系统将声音和运动转换成电的能力 信号使这些技术成为理想的设备，以感测肺和心脏的动态， 从而诊断和监测肺和心脏疾病。此外，微系统工程 提出了微流体领域，该领域正在稳步地找到基于血液的诊断的应用， 因此，血液学应用。为此，根据NHLBI的U 54 POCTRN指南， 亚特兰大微系统工程POC技术中心（ACME POCT）将协助并实现 来自全国各地的发明家，他们开发了基于微系统的POC技术， 肺部、血液学和睡眠应用，超出概念验证范围，无法定义其特定的临床应用 需要，进行临床验证，并完善他们的技术，目的是加快道路， 翻译和临床采用，并直接解决其中的障碍。ACME POCT独一无二 利用亚特兰大埃默里大学医院和儿童医院的全国顶级临床项目， 亚特兰大的医疗保健，全国最大的儿科医院系统之一，以及国际上 在格鲁吉亚理工学院，包括电子研究所， 和纳米技术（IEN），以及其他独一无二的医疗器械原型设计、创新和试验平台 设施ACME POCT PI独特地平衡了中心的工程和临床方面， 包括Wilbur Lam，医学博士，博士，埃默里大学的临床血液学家和格鲁吉亚理工学院的生物工程师， 在POC诊断开发和商业化方面，著名的微系统公司奥利弗布兰德博士 工程师和格鲁吉亚理工学院的IEN负责人，以及埃默里大学的临床肺病学家Greg Martin，医学博士，理学硕士， 亚特兰大国立卫生研究院资助的CTSA的临床研究负责人。重要的是，ACME POCT的领导层有一个 在管理促进医疗器械开发的中心方面的合作历史和跟踪记录。

The advent of point-of-care (POC) diagnostic capabilities has enabled rapid and timely clinical evaluation in the physician's office, an ambulance, the home, the field, or in the hospital and has the potential to significantly impact health care delivery. In cardiology, pulmonology/critical care, and hematology, POC testing plays an especially significant role as the heart and lungs are among the most vital of organs necessitating real time diagnosis and rapid management during critical illnesses, while pathologic alternations in blood are associated with critical, systemic illness. One class of novel medical technologies that is showing promise for POC applications are microsystems-engineered technologies, that is, microchip-enabled devices ranging from microelectromechanical systems (MEMs)-based sensors, microfluidics, to even smartphone-based systems. Notable for their small size and power requirements, microchip-based systems provide the portability that is vital for POC testing. In addition, the capability of microsystems to convert sound and movement into electrical signals enable these technologies to be ideal devices to sense the dynamics of the lungs and heart and therefore to diagnose and monitor pulmonary and cardiac disorders. Moreover, microsystems engineering has brought forth the field of microfluidics, which is steadily finding applications for blood-based diagnostics, and therefore, hematologic applications. To that end, per the NHLBI's U54 POCTRN guidelines, the overall goal of the Atlanta Center for Microsystems Engineered POC Technologies (ACME POCT) is to assist and enable inventors from across the country who have developed microsystems-based POC technologies for cardiac, pulmonary, hematologic and sleep applications that are beyond proof-of-concept to define their specific clinical needs, conduct clinical validation, and refine their technology, with the objective of accelerating the path to translation and clinical adoption and directly addressing the barriers thereof. The ACME POCT uniquely leverages Atlanta's nationally top-ranked clinical programs at Emory University's hospitals and Children's Healthcare of Atlanta, one of the nation's largest pediatric hospital systems, as well the internationally acclaimed microsystems engineering expertise at Georgia Tech, which includes the Institute for Electronics and Nanotechnology (IEN), and other one-of-a-kind medical device prototyping, innovation, and testbed facilities. The ACME POCT PI's uniquely balance the engineering and clinical sides of the Center and comprise Wilbur Lam, MD, PhD, a clinical hematologist at Emory and Georgia Tech bioengineer with expertise in POC diagnostic development and commercialization, Oliver Brand, PhD, a renowned microsystems engineer and head of Georgia Tech's IEN, and Greg Martin, MD, MSc, a clinical pulmonologist at Emory and head of clinical research in Atlanta's NIH-funded CTSA. Importantly, the leadership of the ACME POCT has a history of collaboration and track record in managing Centers that have fostered medical device development.