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Patient-derived Xenograft Core Facility (PDXCF)

患者来源的异种移植核心设施 (PDXCF)

基本信息

批准号：
10487417
负责人：
Elena Nikolaevna Pugacheva
金额：
$ 17.41万
依托单位：
WEST VIRGINIA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10487417
关键词：
3-Dimensional Amendment Animal Model Appalachian Region Award Basic Science Biomedical Research Breeding Cancer Model Cancer Patient Centers of Research Excellence Chemoresistance Clinic Clinical Sciences Core Facility Development Environment Extramural Activities Fees Funding Generations Genetic Genetic Variation Goals Human IACUC Immune Immune system Immunotherapy In Vitro Institutes Institutional Review Boards Investments Life Malignant Neoplasms Medical Genetics Mesenchymal Stem Cells Mission Modeling Molecular Mus Patients Pharmaceutical Preparations Population Preclinical Drug Evaluation Procedures Process Productivity Protocols documentation Research Research Infrastructure Research Personnel Research Project Grants Resources Role Sampling Science Services Source Standardization Structure Testing Therapeutic Therapeutic Uses Tissue Banks Tissue Sample Tissue Transplantation Tissues Translating Translational Research Transplantation Tumor-Derived Vendor West Virginia Work Xenograft Model anticancer research cancer health disparity cancer subtypes cancer therapy design human model human tissue improved in vivo evaluation innovation neoplastic cell novel novel therapeutics operation patient derived xenograft model patient population patient response personalized medicine pre-clinical programs quality assurance reconstitution reconstruction success therapeutic evaluation tissue processing tool tumor tumor growth tumor heterogeneity tumor microenvironment tumor xenograft

项目摘要

PROJECT SUMMARY/ABSTRACT The Patient-Derived Xenograft Core Facility (PDXCF) has been recently established and evolved from institutional investments in a breeding colony of immunodeficient (NSG) mice, and the efforts of a cancer research investigator who worked to develop tractable animal models of human tumors. The mission of the PDXCF is to generate cutting edge cancer models that closely resemble heterogeneous human cancers for investigators in the Tumor Microenvironment (TME) Center of Biomedical Research Excellence (CoBRE) as the top priority, and to investigators across the campus to broaden overall impact of this resource. This core will enable enhanced understanding of the TME, facilitate development of novel cancer therapeutics, and improve pre-clinical drug evaluation. Services offered to investigators will be tailored to best fit the needs of research projects in the TME CoBRE. The PDXCF core will provide the following services: 1) transplantation of tissue samples provided by investigators to produce new PDX lines; 2) propagation of established PDX lines; and 3) assistance with submission of IRB and IACUC protocols/amendments. By expanding the research infrastructure, this core facility enables researchers to be more competitive for extramural funding, establish and grow productive research programs, and improve the process of translating basic science to therapeutic application. The proposal describes services provided by the facility along with its management plan, fee structure, prioritization, quality assurance plan, and strategies to sustain the facility over the life of the project and beyond. The Specific Aims of the WVU PDXCF are: 1) to advance the translational research and optimal productivity of the Project Leaders (PLs); 2) to support and develop the core for applications outside the initial TME CoBRE project leaders, and to support the activities of the WVUCI and other WV Institutional Development Award (IDeA) programs that share the overarching goal to reduce cancer health disparities through innovative translational science. Importantly, this core facility will increase the availability of tumor cells from a patient population that is underrepresented in currently available commercial PDX sources.

项目总结/文摘