Patient-derived Xenograft Core Facility (PDXCF)
患者来源的异种移植核心设施 (PDXCF)
基本信息
- 批准号:10213074
- 负责人:
- 金额:$ 17.42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-01 至 2023-06-30
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAmendmentAnimal ModelAppalachian RegionAwardBasic ScienceBiomedical ResearchBreedingCancer ModelCancer PatientCenters of Research ExcellenceChemoresistanceClinicClinical SciencesCore FacilityDevelopmentEnvironmentExtramural ActivitiesFeesFundingGenerationsGeneticGenetic VariationGoalsHumanIACUCImmuneImmune systemImmunotherapyIn VitroInstitutesInstitutional Review BoardsInvestmentsLifeMalignant NeoplasmsMedical GeneticsMesenchymal Stem CellsMissionModelingMolecularMusPatientsPharmaceutical PreparationsPopulationPreclinical Drug EvaluationProceduresProcessProductivityProtocols documentationResearchResearch InfrastructureResearch PersonnelResearch Project GrantsResourcesRoleSamplingScienceServicesSourceStandardizationStructureTestingTherapeuticTherapeutic UsesTissue BanksTissue SampleTissue TransplantationTissuesTranslatingTranslational ResearchTransplantationTumor-DerivedVendorWest VirginiaWorkXenograft Modelanticancer researchcancer health disparitycancer subtypescancer therapydesignhuman modelhuman tissueimprovedin vivo evaluationinnovationneoplastic cellnovelnovel therapeuticsoperationpatient derived xenograft modelpatient populationpatient responsepersonalized medicinepre-clinicalprogramsquality assurancereconstitutionreconstructionsuccesstherapeutic evaluationtissue processingtooltumortumor growthtumor heterogeneitytumor microenvironmenttumor xenograft
项目摘要
PROJECT SUMMARY/ABSTRACT
The Patient-Derived Xenograft Core Facility (PDXCF) has been recently established and evolved from
institutional investments in a breeding colony of immunodeficient (NSG) mice, and the efforts of a cancer
research investigator who worked to develop tractable animal models of human tumors. The mission of the
PDXCF is to generate cutting edge cancer models that closely resemble heterogeneous human cancers for
investigators in the Tumor Microenvironment (TME) Center of Biomedical Research Excellence (CoBRE) as the
top priority, and to investigators across the campus to broaden overall impact of this resource. This core will
enable enhanced understanding of the TME, facilitate development of novel cancer therapeutics, and improve
pre-clinical drug evaluation. Services offered to investigators will be tailored to best fit the needs of research
projects in the TME CoBRE. The PDXCF core will provide the following services: 1) transplantation of tissue
samples provided by investigators to produce new PDX lines; 2) propagation of established PDX lines; and 3)
assistance with submission of IRB and IACUC protocols/amendments. By expanding the research infrastructure,
this core facility enables researchers to be more competitive for extramural funding, establish and grow
productive research programs, and improve the process of translating basic science to therapeutic application.
The proposal describes services provided by the facility along with its management plan, fee structure,
prioritization, quality assurance plan, and strategies to sustain the facility over the life of the project and beyond.
The Specific Aims of the WVU PDXCF are: 1) to advance the translational research and optimal productivity of
the Project Leaders (PLs); 2) to support and develop the core for applications outside the initial TME CoBRE
project leaders, and to support the activities of the WVUCI and other WV Institutional Development Award (IDeA)
programs that share the overarching goal to reduce cancer health disparities through innovative translational
science. Importantly, this core facility will increase the availability of tumor cells from a patient population that is
underrepresented in currently available commercial PDX sources.
项目总结/摘要
最近建立了患者源性异种移植核心设施(PDXCF),
在免疫缺陷(NSG)小鼠的繁殖群体中的机构投资,以及癌症研究人员的努力,
致力于开发易于处理的人类肿瘤动物模型的研究者。联合国的使命
PDXCF旨在生成与异质性人类癌症非常相似的尖端癌症模型,
肿瘤微环境(TME)生物医学研究卓越中心(CoBRE)的研究人员作为
最高优先级,并在校园内的调查人员,以扩大这一资源的整体影响。核心将
能够增强对TME的理解,促进新型癌症治疗剂的开发,并改善
临床前药物评价。向研究者提供的服务将根据研究需要量身定制
TME CoBRE中的项目。PDXCF核心将提供以下服务:1)组织移植
研究者提供的用于生产新PDX系的样品; 2)已建立的PDX系的繁殖;以及3)
协助提交IRB和IACUC方案/修正案。通过扩大研究基础设施,
这一核心设施使研究人员能够更有竞争力的校外资金,建立和发展
生产性研究计划,并改善基础科学转化为治疗应用的过程。
该提案描述了设施沿着提供的服务及其管理计划、收费结构,
优先次序、质量保证计划和在项目生命周期及以后维持设施的战略。
WVU PDXCF的具体目标是:1)推进翻译研究和最佳生产力,
项目负责人(PL); 2)支持和开发初始TME CoBRE之外的应用程序的核心
项目负责人,并支持WVUCI和其他WV机构发展奖(IDEA)的活动
共同的总体目标是通过创新的转化减少癌症健康差异的计划
科学重要的是,这一核心设施将增加来自患者群体的肿瘤细胞的可用性,
在目前可用的商业PDX来源中代表性不足。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Elena Nikolaevna Pugacheva其他文献
Elena Nikolaevna Pugacheva的其他文献
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{{ truncateString('Elena Nikolaevna Pugacheva', 18)}}的其他基金
Developing a system for PDX in vivo genetic manipulation and selection
开发 PDX 体内遗传操作和选择系统
- 批准号:
9756342 - 财政年份:2018
- 资助金额:
$ 17.42万 - 项目类别:
Patient-derived Xenograft Core Facility (PDXCF)
患者来源的异种移植核心设施 (PDXCF)
- 批准号:
10487417 - 财政年份:2018
- 资助金额:
$ 17.42万 - 项目类别:
THE ROLE OF HEF1 PROTEIN IN INVASION OF METASTATIC BREAST CANCER
HEF1 蛋白在转移性乳腺癌侵袭中的作用
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8167962 - 财政年份:2010
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The role of HEF1 protein in division and invasion of metastatic breast cancer
HEF1蛋白在转移性乳腺癌分裂和侵袭中的作用
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8608492 - 财政年份:2010
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The role of HEF1 protein in division and invasion of metastatic breast cancer
HEF1蛋白在转移性乳腺癌分裂和侵袭中的作用
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8050024 - 财政年份:2010
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The role of HEF1 protein in division and invasion of metastatic breast cancer
HEF1蛋白在转移性乳腺癌分裂和侵袭中的作用
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8215921 - 财政年份:2010
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The role of HEF1/NEDD9 protein in proliferation and invasion of metastatic breast cancer
HEF1/NEDD9蛋白在转移性乳腺癌增殖和侵袭中的作用
- 批准号:
9981662 - 财政年份:2010
- 资助金额:
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The role of HEF1/NEDD9 protein in proliferation and invasion of metastatic breast cancer
HEF1/NEDD9蛋白在转移性乳腺癌增殖和侵袭中的作用
- 批准号:
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The role of HEF1 protein in division and invasion of metastatic breast cancer
HEF1蛋白在转移性乳腺癌分裂和侵袭中的作用
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The role of HEF1/NEDD9 protein in proliferation and invasion of metastatic breast cancer
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9355102 - 财政年份:2010
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