Comparison of cervical intraepithelial neoplasia 2/3 treatment outcomes with a portable LMIC-adapted thermal ablation device vs. gas-based cryotherapy

便携式 LMIC 热消融装置与气体冷冻疗法对宫颈上皮内瘤变 2/3 治疗结果的比较

基本信息

  • 批准号:
    10488168
  • 负责人:
  • 金额:
    $ 63.19万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-01-12 至 2024-06-30
  • 项目状态:
    已结题

项目摘要

Project Abstract Cervical cancer is a leading cause of cancer-related mortality among women in low- and middle-income countries (LMICs). The World Health Organization recently released guidelines that endorse alternatives to cytology-based screening, including HPV-based screening and visual inspection with acetic acid (VIA), which will facilitate increased screening coverage and detection of curable precursors to cervical cancer. In order to reduce the burden of cervical cancer, highly effective screening strategies must be combined with affordable and accessible treatment of precancerous lesions. The standard treatment for cervical precancer, gas-based cryotherapy, is often not accessible in LMICs because gas tanks are generally expensive, difficult to obtain, and hard to transport. With the number of screening options increasing, an urgent need exists for a point-of- care treatment technology that is accessible, portable, and inexpensive. We innovated the original thermoablator, an existing cervical precancer treatment device with a probe heated to 100-120º C, for use on a wider scale by customizing the device for LMICs in order to meet this need. This academic-industrial partnership will compare this novel device to traditional CO2-based cryotherapy for the treatment of cervical precancer in LMICs. The Specific Aims of this project are to 1) modify a novel thermoablation prototype adapted and optimized specifically for treatment of cervical precancer in LMICs, determine a more nearly optimal patient- centered protocol for treatment of high-grade precancer, demonstrate that the efficacy of LMIC-adapted thermoablator is non-inferior to CO2-based cryotherapy for the treatment of cervical precancer, and determine the cost-effectiveness of all evaluated therapeutic and post-treatment surveillance strategies. The hypothesis being tested is that this novel device is non-inferior to CO2-based cryotherapy in terms of clinical validity and cost- effectiveness. The research team has well-established relationships with leading regional organizations that provide guidance to government-run cervical cancer prevention programs. Deployment of the LMIC-adapted thermoablator to existing programs will not only improve program efficacy, but will also serve as a model for adoption of this technology in the region. The results of this study will affect other research areas by serving as a springboard to exploring treatment alternatives that are amenable to low-resource settings and thus will reach the most vulnerable populations.
项目摘要

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Miriam Cremer其他文献

Miriam Cremer的其他文献

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{{ truncateString('Miriam Cremer', 18)}}的其他基金

Development of an HPV stigma assessment scale and a stigma-reducing intervention to improve cervical cancer prevention in El Salvador
制定 HPV 耻辱评估量表和减少耻辱干预措施,以改善萨尔瓦多的宫颈癌预防
  • 批准号:
    10844859
  • 财政年份:
    2023
  • 资助金额:
    $ 63.19万
  • 项目类别:
Single Visit Clinical Validation of ScreenFire, a Low-Cost HPV Test: Efficacy and Cost Effectiveness (SCALE)
ScreenFire(一种低成本 HPV 检测)的单次临床验证:功效和成本效益 (SCALE)
  • 批准号:
    10595668
  • 财政年份:
    2022
  • 资助金额:
    $ 63.19万
  • 项目类别:
PROGRESS: PRevention of cervical cancer using the Genotyping scREening and Same-day Self-sampling
进展:利用基因分型筛查和当天自我采样预防宫颈癌
  • 批准号:
    10696230
  • 财政年份:
    2022
  • 资助金额:
    $ 63.19万
  • 项目类别:
Single Visit Clinical Validation of ScreenFire, a Low-Cost HPV Test: Efficacy and Cost Effectiveness (SCALE)
ScreenFire(一种低成本 HPV 检测)的单次临床验证:功效和成本效益 (SCALE)
  • 批准号:
    10340927
  • 财政年份:
    2022
  • 资助金额:
    $ 63.19万
  • 项目类别:
PROGRESS: PRevention of cervical cancer using the Genotyping scREening and Same-day Self-sampling
进展:利用基因分型筛查和当天自我采样预防宫颈癌
  • 批准号:
    10491481
  • 财政年份:
    2022
  • 资助金额:
    $ 63.19万
  • 项目类别:
Comparison of cervical intraepithelial neoplasia 2/3 treatment outcomes with a portable LMIC-adapted thermal ablation device vs. gas-based cryotherapy
便携式 LMIC 热消融装置与气体冷冻疗法对宫颈上皮内瘤变 2/3 治疗结果的比较
  • 批准号:
    10662503
  • 财政年份:
    2018
  • 资助金额:
    $ 63.19万
  • 项目类别:
Comparison of cervical intraepithelial neoplasia 2/3 treatment outcomes with a portable LMIC-adapted thermal ablation device vs. gas-based cryotherapy
便携式 LMIC 热消融装置与气体冷冻疗法对宫颈上皮内瘤变 2/3 治疗结果的比较
  • 批准号:
    10411389
  • 财政年份:
    2018
  • 资助金额:
    $ 63.19万
  • 项目类别:
Development of an LMIC-adapted Thermocoagulation Prototype for the Treatment of Cervical Pre-cancer.
开发适合 LMIC 的热凝原型,用于治疗宫颈癌前病变。
  • 批准号:
    9903657
  • 财政年份:
    2018
  • 资助金额:
    $ 63.19万
  • 项目类别:
CryoPen: An Innovative Treatment for Cervical Precancer in Low-Resource Setting
CryoPen:资源匮乏环境下宫颈癌前病变的创新治疗方法
  • 批准号:
    9355105
  • 财政年份:
    2015
  • 资助金额:
    $ 63.19万
  • 项目类别:
CryoPen: An Innovative Treatment for Cervical Precancer in Low-Resource Setting
CryoPen:资源匮乏环境下宫颈癌前病变的创新治疗方法
  • 批准号:
    8930106
  • 财政年份:
    2015
  • 资助金额:
    $ 63.19万
  • 项目类别:

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