Core 1 Oncogenomics and Bioinformatics Core (OGB)

共享资源核心(OGB)摘要 功能基因组学方法对人类恶性肿瘤疾病进行了广泛的研究 在过去的十年中，允许识别不同的癌症分子亚型和发展预后 和预测性生物标记物。然而，目前还没有关于突变和突变的全面筛查的研究报道。 艾滋病相关恶性肿瘤(AM)的转录图谱。U54的三个相互关联的项目将雇用 下一代测序(NGS)平台用于AM活检的突变和转录组学研究 以及使用不同的小鼠模型和癌细胞系进行的体外和体内肿瘤研究。详细解开了 AM基因组加上对其转录组及其病毒相关因子的更深入了解，将是 有助于理解控制这些肿瘤进展的分子机制和途径 损伤。 我们将创建双边肿瘤基因组学(位于美国密歇根大学)和生物信息学(位于阿根廷UNLP)核心 (OGB)，这将使调查人员能够访问阿根廷实验室和中心目前无法获得的资源 调查人员。双边OGB-Core设施将负责设计、生成、前处理、统计和 对OGB Core提供的NGS平台生成的功能基因组数据进行数据挖掘分析。这个 基因组数据和临床数据将集中在核心服务器上，提供统一的功能基因组资源 这将成为协调趋同方法的枢纽。此外，OGB核心将向所有人提供培训 初级科学家、阿根廷网络调查人员以及通过Pilots吸引的新调查人员 由U54联盟提供的计划。

Shared Resource Core (OGB) Summary Human malignant neoplastic diseases have been extensively characterized by functional genomics approaches during the past decade, allowing the identification of different cancer molecular subtypes and the development of prognostic and predictive biomarkers. However, no studies have been reported comprehensively screening for the mutational and transcriptomic profiles of AIDS-associated malignancies (AM). The three interrelated projects of the U54 will employ the Next Generation Sequencing (NGS) platform to perform mutational and transcriptomics studies of AM biopsies as well as in-vitro and in vivo tumor studies using different murine models and cancer cell lines. Detailed unraveling of the AM genome coupled with a deeper understanding of its transcriptome and their viral associated factors will be instrumental to understand the molecular mechanisms and pathways that govern the progression of these neoplastic lesions. We will create a bilateral Oncogenomics (located at UM, USA) and Bioinformatics (located at UNLP, Argentina) Core (OGB) that will provide investigators access to resources not currently available for the Argentina Labs and centers investigators. The bilateral OGB-Core facility will be in charge of the design, generation, pre-processing, statistical and data mining analysis of the functional genomics data generated by the NGS platform available at OGB Core. The genomic data and clinical data will be centralized at the core server providing unified functional genomics resources that will serve as hub for coordinating converging approaches. Furthermore, the OGB Core will provide training to all junior scientists, Argentina investigators from the network as well as new investigators attracted via Pilots program offered by the U54 Consortium.