Core 1 Oncogenomics and Bioinformatics Core (OGB)

核心 1 肿瘤基因组学和生物信息学核心 (OGB)

• 批准号: 9767732
• 负责人: SION LLEWELYN WILLIAMS
• 金额: $ 9.93万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9767732
• 关键词: AIDS related cancer; Acquired Immunodeficiency Syndrome; Argentina; Bilateral; Bioinformatics; Biopsy; Cancer cell line; Charge; Clinical Data; Clinical Research; Collaborations; Consultations; Core Facility; Coupled; DNA; Data; Development; Disease; Education; Experimental Designs; Gene Expression Profiling; Generations; Genetic; Genome; Genomic approach; Genomics; Goals; Human; In Vitro; Lesion; Literature; Malignant - descriptor; Malignant Neoplasms; Mentors; Modeling; Molecular; Mutation; Pathway interactions; Preparation; Process; Prognostic Marker; RNA; Reporting; Research Personnel; Research Training; Resource Sharing; Resources; Sampling; Science; Scientist; Services; Standardization; Structure; Technology; Training; Viral; base; cancer genomics; carcinogenesis; collaborative environment; cost effective; data integration; data management; data mining; design; functional genomics; genomic data; in vivo; knowledge base; medical schools; member; molecular subtypes; mouse model; mutation screening; nano-string; neoplastic; new therapeutic target; next generation sequencing; predictive marker; predictive test; prognostic; programs; sequencing platform; terabyte; transcriptome; transcriptome sequencing; transcriptomics; tumor; tumor progression

Shared Resource Core (OGB) Summary Human malignant neoplastic diseases have been extensively characterized by functional genomics approaches during the past decade, allowing the identification of different cancer molecular subtypes and the development of prognostic and predictive biomarkers. However, no studies have been reported comprehensively screening for the mutational and transcriptomic profiles of AIDS-associated malignancies (AM). The three interrelated projects of the U54 will employ the Next Generation Sequencing (NGS) platform to perform mutational and transcriptomics studies of AM biopsies as well as in-vitro and in vivo tumor studies using different murine models and cancer cell lines. Detailed unraveling of the AM genome coupled with a deeper understanding of its transcriptome and their viral associated factors will be instrumental to understand the molecular mechanisms and pathways that govern the progression of these neoplastic lesions. We will create a bilateral Oncogenomics (located at UM, USA) and Bioinformatics (located at UNLP, Argentina) Core (OGB) that will provide investigators access to resources not currently available for the Argentina Labs and centers investigators. The bilateral OGB-Core facility will be in charge of the design, generation, pre-processing, statistical and data mining analysis of the functional genomics data generated by the NGS platform available at OGB Core. The genomic data and clinical data will be centralized at the core server providing unified functional genomics resources that will serve as hub for coordinating converging approaches. Furthermore, the OGB Core will provide training to all junior scientists, Argentina investigators from the network as well as new investigators attracted via Pilots program offered by the U54 Consortium.

共享资源核心（OGB）摘要