Center for Studies of Host Response to Cancer Therapy

项目总结/摘要 宿主对癌症治疗反应研究中心的目标是（1）形成一个自我维持的 阿肯色州医学科学大学（UAMS）内的多学科研究中心，以增加 了解癌症治疗副作用的机制，确定早期检测的方法，并开发 预防或治疗这些副作用的策略，以及（2）帮助初级研究人员进行这方面的研究计划 共同的主题确立自己作为独立的科学家。实现这些目标将创造一个充满活力， 多学科协同研究环境。据我们所知，很少有研究中心关注癌症 生存率，没有人采取范式转变的方法，积极解决治疗相关毒性 来改善癌症治疗的整体效果。具体来说，该中心将为年轻人提供一个环境， 研究人员作为独立科学家取得成功（目标1）;加强整体研究基础设施， UAMS和温斯洛普P.洛克菲勒癌症研究所（目标2）;并确保该中心成为自我- 持续（目标3）。在第一阶段招募到中心的所有6名项目负责人都建立了资金充足、富有成效的 研究计划和密切合作，彼此和几个试点项目的赠款。在 为了准备第二阶段，我们招募了4名有前途的新的/早期独立研究者。在阶段 1，该中心重点关注放射治疗。扩大中心的影响和范围， 保留其总体主题，为第二阶段招募的项目领导人的研究重点是辐射和 化疗为了增加项目负责人成功获得独立的校外合作伙伴的可能性， 研究经费，个性化的指导和教师发展计划将得到实施，并从 一个行政核心和两个研究服务核心将是不可分割的。取代那些达到以下目标的项目负责人 独立性和从COBRE支持中毕业，通过以下方式确保了新项目领导人的管道 为招聘初级教师提供机构支持，并结合结构化试点项目计划。加强 我们与其他5个COBRE中心和其他NIH支持的项目的互动，可以增强 UAMS和附属校园的生物医学研究也将有助于建立该中心作为一个 自我维持的研究计划，是很好地融入机构。该中心的进展将受到 高素质的外部和内部咨询委员会。强有力的机构支持与积极的 资助机构对提高单纯性癌症治愈率和癌症患者生活质量的兴趣 幸存者确保了宿主对癌症治疗反应研究中心成功的可能性很高。

PROJECT SUMMARY/ABSTRACT The objectives of the Center for Studies of Host Response to Cancer Therapy are to (1) form a self-sustaining multidisciplinary research center within the University of Arkansas for Medical Sciences (UAMS) to increase the understanding of mechanisms of side effects of cancer therapy, identify methods for early detection, and develop strategies to prevent or treat such side effects and (2) help junior investigators with research programs in this common theme establish themselves as independent scientists. Achieving these goals will create a vibrant, multidisciplinary yet synergistic research environment. To our knowledge, few research centers focus on cancer survivorship, and none take the paradigm-shifting approach of proactively addressing treatment-related toxicities to improve overall cancer treatment outcomes. Specifically, this Center will provide an environment for young investigators to succeed as independent scientists (Aim 1); strengthen the overall research infrastructure at UAMS and the Winthrop P. Rockefeller Cancer Institute (Aim 2); and ensure that the Center becomes self- sustaining (Aim 3). All 6 project leaders recruited to the Center in Phase 1 have built well-funded, productive research programs and close collaborations with each other and several of the pilot project grantees. In preparation for Phase 2, we have recruited 4 promising new/early-stage independent investigators. During Phase 1, the Center focused heavily on radiation therapy. To increase the impact and scope of the Center while retaining its overall theme, project leaders recruited for Phase 2 have a research focus on both radiation and chemotherapy. To increase the likelihood that project leaders will successfully secure independent extramural research funding, individualized mentoring and faculty-development plans will be implemented, and support from an administrative core and 2 research service cores will be integral. To replace project leaders who achieve independence and graduate from COBRE support, a pipeline of new project leaders is ensured through institutional support for recruiting junior faculty combined with a structured pilot project program. Strengthening our interactions with the 5 other COBRE Centers and additional NIH-supported programs that enhance biomedical research on the UAMS and affiliated campuses will also contribute to establishing the Center as a self-sustaining research program that is well-integrated in the institution. The Center's progress will be guided by highly qualified External and Internal Advisory Committees. Strong institutional support combined with active interest from funding agencies in improving uncomplicated cancer cure rates and the quality of life of cancer survivors ensures a high likelihood of success for the Center for Studies of Host Response to Cancer Therapy.