Irradiation and Animal Core

项目摘要/摘要 对癌症治疗副作用生物学的翻译研究在很大程度上依赖于体内的复杂情况 研究模型需要特定的专业知识来设计、开发、实施和 故障排除。新的研究人员经常在他们的研究需要使用时遇到启动问题 这些模型中的。辐射和动物核心(核心C)的主要目标是促进 中心研究人员开发和使用临床前动物模型和放射生物学原理 为研究宿主对癌症治疗的反应和校园内的其他科布雷中心。第二个 目标是将核心发展成为一个自给自足的设施，为整个研究基础设施做出贡献 该机构的成员。在项目第一阶段，核心构建了强大的辐射研究基础设施， 小动物的分辨率超声成像，以及动物的饲养和处理程序。辐射和 超声波服务也作为一种收费服务提供给我们机构的所有调查人员 该地区的其他国家。在第二阶段，核心将在此基础上建立，以提供项目负责人和试点 为动物和辐射模型的开发和维护提供资源的项目受赠人(目标1)， 为畜牧业和辐射生物学的早期调查人员提供指导和培训(目标 2)，并将核心发展为一个自给自足的设施，改善校园的研究基础设施 (目标3)。核心将就转基因动物模型的生成提供建议和协助，导航 动物保护和利用机构委员会、最佳动物繁育计划的实施和 其他畜牧业问题，以及高分辨率超声波成像的使用。此外，核心 维护5台最先进的实验X射线和γ射线设备。核心人员确认必要的 执行维护、校准和辐射剂量测量以保证高质量的辐射服务， 他们提供放射生物学方面的专家建议，协助中心调查人员制定适当的 为他们的研究提供辐射模型，并帮助他们使用辐照器。核心服务广告、费用 计划维护和预算报告编制将继续进行，并将在必要时进行优化。常规 对核心用户的调查将确定可能需要的其他服务，并与Cobre和机构合作 支持，将开发此类服务。核心C提供的服务将通过以下方式影响中心的研究 协助中心研究人员设计和开发他们的研究模型并提供学习 将促进他们的专业发展成为癌症领域的独立研究人员的经验 治疗副作用。此外，该核心将丰富现有调查人员的研究基础设施。

PROJECT SUMMARY/ABSTRACT Translational research into the biology of cancer therapy side effects relies heavily on complex in vivo research models that require specific expertise for their design, development, implementation, and troubleshooting. New investigators frequently experience startup problems when their research requires the use of these models. The primary objective of the Irradiation and Animal Core (Core C) is to facilitate the development and use of pre-clinical animal models and radiobiological principles by investigators in the Center for Studies of Host Response to Cancer Therapy and other COBRE Centers on campus. The secondary objective is to develop the core into a self-sustaining facility that contributes to the overall research infrastructure of the institution. During Phase 1 of the project, the core built a strong infrastructure for radiation research, high- resolution ultrasound imaging of small animals, and animal breeding and handling procedures. Radiation and ultrasound services also were made available as a fee-for-service to all investigators from our institution and others in the region. During Phase 2, the core will build on this foundation to provide project leaders and pilot project grantees with resources for the development and maintenance of animal and radiation models (Aim 1), to provide mentoring and training for early-stage investigators in animal husbandry and radiation biology (Aim 2), and to develop the core into a self-sustaining facility that improves the research infrastructure on campus (Aim 3). The core will advise on and assist with the generation of transgenic animal models, the navigation of the Institutional Animal Care and Use Committee, the implementation of optimal animal breeding schemes and other animal husbandry issues, and the use of high-resolution ultrasound imaging. Additionally, the core maintains 5 state-of-the-art experimental X-ray and γ-ray facilities. Core personnel confirm that the necessary maintenance, calibration, and radiation dosimetry are performed to guarantee high-quality radiation services, and they provide expert advice in radiobiological matters, assist Center investigators in developing appropriate radiation models for their research, and assist them in the use of the irradiators. Core services advertising, fee schedule maintenance, and budget report preparation will continue and will be optimized if necessary. Regular surveys among core users will identify additional services that may be required, and with COBRE and institutional support, such services will be developed. The services provided by Core C will impact the Center's research by assisting Center investigators in the design and development of their research models and offer learning experiences that will enhance their professional development into independent researchers in the area of cancer therapy side effects. Moreover, the core will enrich the research infrastructure for established investigators.