Contribution of Sleep Disruption to Memory Impairment and Emotion Dysregulation in Fetal Alcohol Spectrum Disorders

睡眠中断对胎儿酒精谱系障碍中记忆障碍和情绪失调的影响

• 批准号: 10491056
• 负责人: SANDRA W. JACOBSON
• 金额: $ 12.15万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-25 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10491056
• 关键词: 16 year old; Address; Affect; Affective; Age; Alcohol-Related Neurodevelopmental Disorder; Arousal; Attenuated; Back; Behavioral; Case Study; Child; Clinical; Cognitive; Cohort Studies; Collaborations; Data; Development; Doctor of Medicine; Drowsiness; Emotional; Emotions; Environment; Equipment; Event; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal Alcohol Syndrome; Fetal alcohol effects; Gold; Image; Impairment; Individual; Infant; Intervention; Interview; Investigation; Laboratories; Lead; Learning; Literature; Longitudinal cohort; Measurement; Measures; Mediating; Memory; Memory impairment; Methodology; Methods; Monitor; Mothers; Neurocognitive; Newborn Infant; Outcome; Participant; Pathway interactions; Pattern; Performance; Persons; Play; Polysomnography; Population; Post-Traumatic Stress Disorders; Pregnant Women; Prevalence; Procedures; Province; Psychophysiology; Public Health; REM Sleep; Reaction; Research; Rest; Role; Science; Short-Term Memory; Site; Sleep; Sleep Architecture; Sleep Disorders; Sleep disturbances; Sleeplessness; Slow-Wave Sleep; South Africa; Stimulus; Testing; TimeLine; Universities; alcohol consumption during pregnancy; alcohol exposure; alcohol measurement; attenuation; base; biobehavior; cohort; emotion dysregulation; emotion regulation; epidemiology study; experience; eyeblink conditioning; infancy; innovation; memory consolidation; neuroimaging; novel; prospective; recruit; response; sleep onset; sleep pattern; standardize measure; young adult

ABSTRACT Prenatal alcohol exposure (PAE) is associated with a broad range of adverse and enduring consequences, including impaired learning and memory and altered responses to emotion-laden events (i.e., emotion dysregulation). Although sleep problems are often noted in epidemiological studies and clinical case reports relating to fetal alcohol spectrum disorders (FASD), they have not been well characterized using objective methodologies, such as polysomnography (PSG). Moreover, no studies have explored possible associations between sleep problems and memory and emotional regulation impairments in FASD. Investigation of these associations is warranted because healthy sleep is known to play a critical role in the consolidation of newly-acquired declarative memories and to attenuate emotional reactivity to affectively- valenced stimuli. The proposed study will be the first to investigate sleep architecture and its relation to memory consolidation and emotional regulation in FASD. 90 young adults (18-21 yr of age; 30 fetal alcohol syndrome (FAS) or partial FAS (PFAS), 30 non-syndromal heavily-exposed, and 30 non-exposed controls) will be recruited from PI Sandra Jacobson’s and Co-I Joseph Jacobson’s well-characterized Cape Town, South Africa, FASD cohort, which has been followed longitudinally since infancy. The data will be collected in PI Thomas’s Sleep Sciences Laboratory at the University of Cape Town. Cape Town is an excellent venue for this study given the unusually large number of individuals with heavy PAE and FAS available at a single site and the availability of a state-of-the-art PSG-equipped laboratory. Sleep data will be obtained over three consecutive nights. The 1st (adaptation) night will allow participants to acclimate to the sleep laboratory’s environment and to sleeping with monitoring equipment attached. Sleep on the 2nd night will be preceded by learning trials of standard declarative memory tests, which have been found to be affected by PAE, and will be followed in the morning by delayed recall trials. This procedure will allow us to examine associations between sleep disruption and memory consolidation. Sleep on the 3rd night will be preceded by initial viewing of valenced pictures and will be followed in the morning by viewing of the same stimuli. Psychophysiological measurement during both pre- and post-sleep viewing will allow us to examine associations between sleep disruption and affective arousal/emotion regulation. The aims are (1) to characterize sleep architecture of young adults with FASD; (2) to test the hypothesis that reductions in slow-wave sleep (SWS) percentage will mediate PAE-related disruptions in memory consolidation; and (3) to test the hypothesis that reductions in rapid eye movement (REM) sleep percentage will mediate PAE- related alterations in emotional reactivity to previously-viewed emotionally-valenced pictures. If the predicted associations are observed, sleep-based interventions may offer important and novel pathways for addressing deficits in declarative memory and emotion regulation in FASD.

摘要 产前酒精暴露（PAE）与广泛的不良和持久的后果有关， 包括受损的学习和记忆以及对充满情绪的事件的改变的反应（即，情感 失调）。虽然在流行病学研究和临床病例中经常注意到睡眠问题 关于胎儿酒精谱系障碍（FASD）的报告，他们还没有得到很好的特点，使用 客观方法，如多导睡眠图（PSG）。此外，还没有研究探讨过 FASD患者睡眠问题与记忆和情绪调节障碍之间的关系。 对这些联系的调查是有必要的，因为健康的睡眠在睡眠中起着关键作用。 巩固新获得的陈述性记忆，并减弱对情感的情绪反应- 有价刺激这项拟议中的研究将是第一个调查睡眠结构及其与睡眠的关系。 记忆巩固和情绪调节。90名年轻成人（18-21岁; 30名胎儿酒精 综合征（FAS）或部分FAS（PFAS），30例非综合征重度暴露组和30例非暴露对照组） 将从PI桑德拉雅各布森和Co-I约瑟夫雅各布森的特点开普敦， 南非，FASD队列，从婴儿期开始就进行纵向随访。数据将被收集 在开普敦大学的PI托马斯睡眠科学实验室。开普敦是一个很好的 考虑到在一个研究中心有异常多的重度PAE和FAS患者， 一个单一的网站和一个国家的最先进的PSG装备实验室的可用性。将获得睡眠数据 连续三个晚上第一个（适应）晚上将允许参与者适应睡眠 实验室的环境和睡眠与监测设备连接。第二天晚上睡觉， 在标准陈述性记忆测试的学习试验之前，已经发现 清晨的时候，他们将迎来一场盛大的宴会。这个程序可以让我们检查 睡眠中断和记忆巩固之间的联系。第三天晚上睡觉之前 通过最初观看有价图片，然后在早上观看相同的刺激。 在睡眠前和睡眠后观看的心理生理测量将使我们能够检查 睡眠中断和情感唤醒/情绪调节之间的关联。目标是（1） 表征FASD年轻成人的睡眠结构;（2）测试以下假设： 慢波睡眠（SWS）百分比将介导记忆巩固中的PAE相关中断;以及（3） 为了检验快速眼动（REM）睡眠百分比的减少将介导PAE的假设， 对以前看过的有情感价值的图片的情感反应的相关改变。如果 预测的关联被观察到，基于睡眠的干预措施可能提供重要和新颖的途径， 解决FASD中陈述性记忆和情绪调节的缺陷。