Brain Injury Knowledge Ontology (BIKO): Identifying Metadata Variance in Traumatic Brain Injury Therapy Studies

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Project Summary Traumatic brain injury is a significant cause of morbidity and mortality in the United States, yet there is no approved therapy for this injury. Although several therapies and procedures have been deemed successful for TBI treatment in preclinical research studies, many of these successes did not translate to human studies. One way to examine this challenge is to investigate the methodological variances in the associated literature. This proposal aims to use experimental methods and outcomes used in traumatic brain injury (TBI) therapy papers to create a metric to compare the methodological variance between multiple species by following three aims: 1. Training Phase 1: Establish the Brain Injury Knowledge Ontology (BIKO), a standardized ontology to define experimental design parameters and outcomes. 2. Training Phase 1: Create a knowledge base, BIKO base, of experimental design parameters (methods) and scientific claims (results) from the TBI treatment discovery literature. 3. Training Phase 2: Compare experimental differences hypothesized to lead to distinct outcomes between and across multiple species in TBI studies/literature using the BIKO. Upon completion, this project will provide a clearer understanding of past preclinical TBI therapy success and how it aligns to clinical outcomes to accelerate the discovery of successful therapies for TBI in human patients.