Polymeric Materials Synthesis and Characterization
高分子材料的合成与表征
基本信息
- 批准号:10490414
- 负责人:
- 金额:$ 31.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-17 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:AdsorptionAmino AcidsAngiogenic PeptidesAnti-Inflammatory AgentsBindingBiological AssayBiopolymersCell Culture TechniquesCellsChargeChemical InjuryChemicalsChemistryClinicalClinical TrialsCollaborationsEncapsulatedExposure toExudative age-related macular degenerationEyeFilmFormulationFree Radical ScavengingGlycolatesGoalsHumanImmuneImmunologyIn VitroInflammationInflammatoryInterleukin-10Intravenous infusion proceduresLaboratoriesLeadLipidsLiquid substanceMechlorethamineMelaninsMicrobiologyModelingModificationMustardMustard GasNaturePeptidesPlayPolymersPorosityPositioning AttributePreparationProductionPropertyProteinsRednessRetinaRoleSiteSkinSkin injurySolubilitySurfaceSystemTechnologyTestingTherapeuticTissuesTransforming Growth Factor betaTranslatingUniversitiesValidationVitamin DWorkbasebiocompatible polymerbiodegradable polymercarboxylateclinical translationcytokinedirect applicationexperimental studyimprovedin vivoinnovationinterestkeratinocytelead candidatemacrophagematerials sciencemonocytemonomernanomaterialsnanoparticlenovelparticleprotein aminoacid sequenceremediationscale upskin burnsmall moleculesurface coatingtherapeutic nanoparticlestissue injurytoolultraviolet irradiationuptake
项目摘要
Project Summary
The Polymeric Materials Synthesis and Characterizations Core will formulate, synthesize, and characterize lead
candidates for the mitigation of mustards and provide support and chemical expertise to other cores and projects.
The Core will be co-directed by Drs. Nathan Gianneschi (Dept. of Chemistry) and Stephen Miller (Dept. of
Microbiology-Immunology). A tiered approach will be taken to select and optimize such candidates. Initially
properties that enhance the efficacy of the materials would be determined and physiochemical analysis on the
materials of interest would be probed. One such example is our ability to enrich materials for radical scavenging
at the chemical doping level. Other properties would include surface charge, porosity, binding capacity, and
solubility of materials. Depending on the material and application for the skin or eyes, the candidate material will
be formulated as a nanoparticle, or as a surface coating and the delivery could be optimized for its specific
application. That is, materials can be prepared for delivery via direct application as a liquid solution or cast into
a film or in the case of PLGA Immune Modifying Particles (PLGA-IMPs) for intravenous infusion. After initial in
vitro and in vivo studies, materials will be scaled-up for clinical trials, with many of the proposed systems already
known to be amenable to that kind of scale-up. The Polymeric Materials Synthesis and Characterizations Core
will be responsible for advancing the synthesis of materials such as polymers from small molecules, will make
chemical modifications to improve lead compounds/materials, and will synthesize components for the Lipid-
Based Self-Assembled Materials Synthesis and Characterization Core. The goals of this core are to develop
formulations and delivery platforms for lead candidates such as melanin, biodegradable polymeric PLGA IMPs
(which will be further modified by encapsulating anti-inflammatory cytokines (IL-10 and TGF-β) and compounds
(e.g. Vitamin D), and peptide-based delivery systems for the skin and eyes by modifying their physiochemical
properties and by characterizing materials for scale-up and clinical translation. For the Polymeric Materials
Synthesis and Characterizations Core we propose the following Aims: Aim 1: Utilizing melanin for the
remediation and adsorption of mustards; Aim 2: Protein-Like Polymers for treatment of mustard gas in the eye;
and Aim 3: Production and characterization of negatively-charged, biodegradable PLGA Immune-Modifying
Nanoparticles (PLGA-IMPs) for therapeutic treatment of chemical tissue injury.
项目摘要
聚合物材料合成和表征核心将制定、合成和表征铅
该项目将成为缓解芥末病的候选方案,并为其他核心和项目提供支持和化学专业知识。
《核心》将由Nathan Gianneschi博士(Dep.化学系)和Stephen Miller(系的
微生物学-免疫学)。将采取分层的方法来选择和优化这些候选人。最初
将对增强材料功效的性能进行测定并对其进行物理化学分析
将对感兴趣的材料进行探测。一个这样的例子是我们为激进分子清除而丰富材料的能力
在化学掺杂水平上。其他性质包括表面电荷、孔隙率、结合能力和
材料的溶解度。根据皮肤或眼睛的材料和应用,候选材料将
可以配制成纳米颗粒或表面涂层,并且可以根据其特定的特性优化输送
申请。也就是说,材料可以准备好通过直接应用于液体溶液或浇铸成
用于静脉输液的薄膜或PLGA免疫修饰颗粒(PLGA-IMPS)。在初始输入之后
体外和体内研究,材料将扩大到临床试验,许多拟议的系统已经
已知能够适应这种规模的扩大。聚合物材料的合成与表征
将负责推进从小分子合成聚合物等材料,将使
化学修饰以改进先导化合物/材料,并将合成用于脂类的成分-
基于自组装材料的合成与表征核心。这个核心的目标是开发
用于黑色素、可生物降解的聚合物IMPS等候选铅的制剂和输送平台
(将通过包裹抗炎细胞因子(IL-10和转化生长因子-β)和化合物来进一步修改
(例如,维生素D)和基于多肽的皮肤和眼睛给药系统,通过改变它们的物理化学
通过对用于放大和临床翻译的材料进行表征来确定其特性。关于聚合物材料
合成和表征核心我们提出以下目标:目标1:利用黑色素
修复和吸附芥末;目标2:用于治疗眼睛中芥子气的类蛋白质聚合物;
和目标3:带负电荷的可生物降解的PLGA免疫修饰剂的制备和表征
用于治疗化学组织损伤的纳米粒(PLGA-IMPS)。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Nathan Claude Gianneschi其他文献
Nathan Claude Gianneschi的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Nathan Claude Gianneschi', 18)}}的其他基金
Polymeric Materials Synthesis and Characterization
高分子材料的合成与表征
- 批准号:
10682623 - 财政年份:2021
- 资助金额:
$ 31.97万 - 项目类别:
Polymeric Materials Synthesis and Characterization
高分子材料的合成与表征
- 批准号:
10282409 - 财政年份:2021
- 资助金额:
$ 31.97万 - 项目类别:
Programming Pharmacokinetics in Vivo via In Situ Switching of Nanoscale Particle
通过纳米级颗粒的原位切换对体内药代动力学进行编程
- 批准号:
8146821 - 财政年份:2011
- 资助金额:
$ 31.97万 - 项目类别:
相似海外基金
Double Incorporation of Non-Canonical Amino Acids in an Animal and its Application for Precise and Independent Optical Control of Two Target Genes
动物体内非规范氨基酸的双重掺入及其在两个靶基因精确独立光学控制中的应用
- 批准号:
BB/Y006380/1 - 财政年份:2024
- 资助金额:
$ 31.97万 - 项目类别:
Research Grant
Quantifying L-amino acids in Ryugu to constrain the source of L-amino acids in life on Earth
量化 Ryugu 中的 L-氨基酸以限制地球生命中 L-氨基酸的来源
- 批准号:
24K17112 - 财政年份:2024
- 资助金额:
$ 31.97万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Collaborative Research: RUI: Elucidating Design Rules for non-NRPS Incorporation of Amino Acids on Polyketide Scaffolds
合作研究:RUI:阐明聚酮化合物支架上非 NRPS 氨基酸掺入的设计规则
- 批准号:
2300890 - 财政年份:2023
- 资助金额:
$ 31.97万 - 项目类别:
Continuing Grant
Basic research toward therapeutic strategies for stress-induced chronic pain with non-natural amino acids
非天然氨基酸治疗应激性慢性疼痛策略的基础研究
- 批准号:
23K06918 - 财政年份:2023
- 资助金额:
$ 31.97万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Molecular mechanisms how arrestins that modulate localization of glucose transporters are phosphorylated in response to amino acids
调节葡萄糖转运蛋白定位的抑制蛋白如何响应氨基酸而被磷酸化的分子机制
- 批准号:
23K05758 - 财政年份:2023
- 资助金额:
$ 31.97万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Molecular recognition and enantioselective reaction of amino acids
氨基酸的分子识别和对映选择性反应
- 批准号:
23K04668 - 财政年份:2023
- 资助金额:
$ 31.97万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Design and Synthesis of Fluorescent Amino Acids: Novel Tools for Biological Imaging
荧光氨基酸的设计与合成:生物成像的新工具
- 批准号:
2888395 - 财政年份:2023
- 资助金额:
$ 31.97万 - 项目类别:
Studentship
Structurally engineered N-acyl amino acids for the treatment of NASH
用于治疗 NASH 的结构工程 N-酰基氨基酸
- 批准号:
10761044 - 财政年份:2023
- 资助金额:
$ 31.97万 - 项目类别:
Lifestyle, branched-chain amino acids, and cardiovascular risk factors: a randomized trial
生活方式、支链氨基酸和心血管危险因素:一项随机试验
- 批准号:
10728925 - 财政年份:2023
- 资助金额:
$ 31.97万 - 项目类别:
Single-molecule protein sequencing by barcoding of N-terminal amino acids
通过 N 端氨基酸条形码进行单分子蛋白质测序
- 批准号:
10757309 - 财政年份:2023
- 资助金额:
$ 31.97万 - 项目类别: