Polymeric Materials Synthesis and Characterization
高分子材料的合成与表征
基本信息
- 批准号:10490414
- 负责人:
- 金额:$ 31.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-17 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:AdsorptionAmino AcidsAngiogenic PeptidesAnti-Inflammatory AgentsBindingBiological AssayBiopolymersCell Culture TechniquesCellsChargeChemical InjuryChemicalsChemistryClinicalClinical TrialsCollaborationsEncapsulatedExposure toExudative age-related macular degenerationEyeFilmFormulationFree Radical ScavengingGlycolatesGoalsHumanImmuneImmunologyIn VitroInflammationInflammatoryInterleukin-10Intravenous infusion proceduresLaboratoriesLeadLipidsLiquid substanceMechlorethamineMelaninsMicrobiologyModelingModificationMustardMustard GasNaturePeptidesPlayPolymersPorosityPositioning AttributePreparationProductionPropertyProteinsRednessRetinaRoleSiteSkinSkin injurySolubilitySurfaceSystemTechnologyTestingTherapeuticTissuesTransforming Growth Factor betaTranslatingUniversitiesValidationVitamin DWorkbasebiocompatible polymerbiodegradable polymercarboxylateclinical translationcytokinedirect applicationexperimental studyimprovedin vivoinnovationinterestkeratinocytelead candidatemacrophagematerials sciencemonocytemonomernanomaterialsnanoparticlenovelparticleprotein aminoacid sequenceremediationscale upskin burnsmall moleculesurface coatingtherapeutic nanoparticlestissue injurytoolultraviolet irradiationuptake
项目摘要
Project Summary
The Polymeric Materials Synthesis and Characterizations Core will formulate, synthesize, and characterize lead
candidates for the mitigation of mustards and provide support and chemical expertise to other cores and projects.
The Core will be co-directed by Drs. Nathan Gianneschi (Dept. of Chemistry) and Stephen Miller (Dept. of
Microbiology-Immunology). A tiered approach will be taken to select and optimize such candidates. Initially
properties that enhance the efficacy of the materials would be determined and physiochemical analysis on the
materials of interest would be probed. One such example is our ability to enrich materials for radical scavenging
at the chemical doping level. Other properties would include surface charge, porosity, binding capacity, and
solubility of materials. Depending on the material and application for the skin or eyes, the candidate material will
be formulated as a nanoparticle, or as a surface coating and the delivery could be optimized for its specific
application. That is, materials can be prepared for delivery via direct application as a liquid solution or cast into
a film or in the case of PLGA Immune Modifying Particles (PLGA-IMPs) for intravenous infusion. After initial in
vitro and in vivo studies, materials will be scaled-up for clinical trials, with many of the proposed systems already
known to be amenable to that kind of scale-up. The Polymeric Materials Synthesis and Characterizations Core
will be responsible for advancing the synthesis of materials such as polymers from small molecules, will make
chemical modifications to improve lead compounds/materials, and will synthesize components for the Lipid-
Based Self-Assembled Materials Synthesis and Characterization Core. The goals of this core are to develop
formulations and delivery platforms for lead candidates such as melanin, biodegradable polymeric PLGA IMPs
(which will be further modified by encapsulating anti-inflammatory cytokines (IL-10 and TGF-β) and compounds
(e.g. Vitamin D), and peptide-based delivery systems for the skin and eyes by modifying their physiochemical
properties and by characterizing materials for scale-up and clinical translation. For the Polymeric Materials
Synthesis and Characterizations Core we propose the following Aims: Aim 1: Utilizing melanin for the
remediation and adsorption of mustards; Aim 2: Protein-Like Polymers for treatment of mustard gas in the eye;
and Aim 3: Production and characterization of negatively-charged, biodegradable PLGA Immune-Modifying
Nanoparticles (PLGA-IMPs) for therapeutic treatment of chemical tissue injury.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Nathan Claude Gianneschi其他文献
Nathan Claude Gianneschi的其他文献
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{{ truncateString('Nathan Claude Gianneschi', 18)}}的其他基金
Polymeric Materials Synthesis and Characterization
高分子材料的合成与表征
- 批准号:
10682623 - 财政年份:2021
- 资助金额:
$ 31.97万 - 项目类别:
Polymeric Materials Synthesis and Characterization
高分子材料的合成与表征
- 批准号:
10282409 - 财政年份:2021
- 资助金额:
$ 31.97万 - 项目类别:
Programming Pharmacokinetics in Vivo via In Situ Switching of Nanoscale Particle
通过纳米级颗粒的原位切换对体内药代动力学进行编程
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8146821 - 财政年份:2011
- 资助金额:
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