Applying Digital Health to the AF Ablation NCDR, Enabling Longitudinal Follow-up
将数字健康应用于房颤消融 NCDR,实现纵向随访
基本信息
- 批准号:10489829
- 负责人:
- 金额:$ 69.94万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-16 至 2026-07-31
- 项目状态:未结题
- 来源:
- 关键词:AblationAddressAlcohol consumptionAmericanAssessment toolAtrial FibrillationCardiacCardiac Electrophysiologic TechniquesCardiac ablationCardiologyCardiovascular systemCellular PhoneCessation of lifeCharacteristicsClinicalClinical ResearchCodeComplicationCountryCryosurgeryCurrent Procedural Terminology CodesCustomDataData CollectionDatabasesDiseaseEffectivenessElectrophysiology (science)EnrollmentFemaleFistulaFundingFutureGoalsGuidelinesHealth PersonnelHeavy DrinkingICD-9IncidenceInfrastructureInstitutionInternational Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10)InterventionLaboratoriesLife StyleLongitudinal StudiesMethodsNational Heart, Lung, and Blood InstituteOutcomePaperParticipantPatient Outcomes AssessmentsPatientsProceduresProfessional OrganizationsProspective cohortPublishingQuality of lifeRadiofrequency Interstitial AblationRecommendationRegistriesReportingResearchResearch PersonnelResearch Project GrantsResourcesRiskRunningSafetySecureTestingTimeUnited States National Institutes of HealthVisitWorkadministrative databasebasebiomedical referral centerclinically relevantcollegedata registrydigitaldigital healtheffectiveness evaluationexperiencefollow-upheart rhythmhigh riskimplantationindexinginterestlifestyle factorsmHealthmembermobile applicationmortalityoperationpatient registryprospectiverandomized trialremote consentsecondary analysissexsmartphone Applicationstandard of caresymptomatic improvementtool
项目摘要
PROJECT SUMMARY/ABSTRACT
Atrial fibrillation ablation is the most common procedure performed in electrophysiology laboratories and
continues to grow more rapidly than any other EP procedure. A recent NHLBI report highlighted the research
needs and priorities for catheter ablation of AF, emphasizing the importance of real-world evidence and the
lack of longitudinal, multi-center, data collection platforms to inform patients and healthcare providers. The
current proposal seeks to merge two extant resources to help fulfill those needs: the AF Ablation National
Cardiovascular Data Registry (NCDR) and the NIH-supported Eureka mobile health research platform. The AF
Ablation NCDR is a well-established quality assessment tool currently already in operation in 200 institutions
around the US, utilizing comprehensive and carefully vetted and regularly audited data collection forms to
ascertain detailed information regarding patient, procedure, and institution-level information. However, the AF
Ablation NCDR does not capture longitudinal information regarding procedural effectiveness, safety, or patient
reported outcomes. Eureka, co-developed and run by the proposed PI of the current project, is a digital
infrastructure built to facilitate mobile health-based research, providing established workflows to obtain remote
consent, actively engage with and collect information directly from research participants via a mobile app,
employ technical integrations to passively collect data from smartphones, and utilizes a reliable and secure
backend database to curate and transmit the resultant data. We propose to co-enroll AF Ablation NCDR
patients into a customized Eureka tenant, enabling longitudinal data collection in a pragmatic fashion. While
the overarching goal of this project will be to leverage these efforts to efficiently construct a resource available
for multiple secondary analyses, ancillary projects, and future projects for interested investigators, we will
demonstrate the utility of the merged infrastructure to pursue three immediately clinically relevant Aims.
In Aim 1, we will determine the relative influences of patient-level, procedural-level, and institution-level
characteristics as predictors of AF Ablation effectiveness and risk in this multi-center, real-world, prospective
cohort, specifically testing the hypotheses that female sex, cryoablation (rather than radiofrequency ablation),
and procedures performed in non-teaching hospitals will each be associated with reduced effectiveness and
more frequent complication. In Aim 2, we will seek to determine how lifestyle factors may influence AF Ablation
outcomes, specifically testing the hypothesis that reduced alcohol consumption after ablation is associated with
greater effectiveness. In Aim 3, we will seek to demonstrate how this large multi-center database may be
useful in characterizing rare but especially clinically relevant complications, specifically to describe the
incidence and predictors of atrioesophageal fistula. Taken together, we will work to create a practically useful
platform that cultivates original research to inform optimal approaches to AF ablation procedures in the real
world.
项目总结/摘要
心房颤动消融术是在电生理实验室中进行的最常见的手术,
比任何其他EP手术都增长得更快。NHLBI最近的一份报告强调了这项研究
房颤导管消融的需求和优先事项,强调真实世界证据的重要性,
缺乏纵向的、多中心的数据收集平台,以告知患者和医疗保健提供者。的
目前的建议旨在合并两个现存的资源,以帮助满足这些需求:房颤消融国家
心血管数据登记(NCDR)和NIH支持的尤里卡移动的健康研究平台。的AF
消融NCDR是一个完善的质量评估工具,目前已在200个机构中运行
在美国各地,利用全面、仔细审查和定期审计的数据收集表格,
确定有关患者、程序和机构级信息的详细信息。然而,AF
消融NCDR未捕获关于手术有效性、安全性或患者的纵向信息
报告结果。尤里卡,共同开发和运行的建议PI的当前项目,是一个数字
为促进移动的健康研究而建立的基础设施,提供既定的工作流程,
同意,积极参与并通过移动的应用程序直接从研究参与者收集信息,
采用技术集成从智能手机被动收集数据,并利用可靠和安全的
后端数据库来管理和传输结果数据。我们建议共同入组AF消融NCDR
将患者转变为定制的尤里卡租户,以务实的方式实现纵向数据收集。而
该项目的总体目标是利用这些努力,有效地构建一个可用的资源
对于多个次要分析、辅助项目和感兴趣的研究者的未来项目,我们将
展示合并后的基础设施的效用,以实现三个直接临床相关的目标。
在目标1中,我们将确定患者层面、程序层面和机构层面的相对影响
在这项多中心、真实世界、前瞻性研究中,
队列,专门检验女性、冷冻消融(而非射频消融)
在非教学医院进行的手术将与有效性降低有关,
更频繁的并发症。在目标2中,我们将寻求确定生活方式因素如何影响房颤消融
结果,特别是测试消融术后饮酒量减少与
更高的效率。在目标3中,我们将试图展示这个大型多中心数据库如何
用于表征罕见但特别是临床相关的并发症,特别是描述
心房食管瘘的发病率和预测因素。总之,我们将努力创造一个实际有用的
培养原创研究的平台,为真实的房颤消融手术提供最佳方法
世界
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
GREGORY M MARCUS其他文献
GREGORY M MARCUS的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('GREGORY M MARCUS', 18)}}的其他基金
Applying Digital Health to the AF Ablation NCDR, Enabling Longitudinal Follow-up
将数字健康应用于房颤消融 NCDR,实现纵向随访
- 批准号:
10672387 - 财政年份:2021
- 资助金额:
$ 69.94万 - 项目类别:
Applying Digital Health to the AF Ablation NCDR, Enabling Longitudinal Follow-up
将数字健康应用于房颤消融 NCDR,实现纵向随访
- 批准号:
10278345 - 财政年份:2021
- 资助金额:
$ 69.94万 - 项目类别:
The Health ePeople Resource for Mobilized Research
用于动员研究的 Health ePeople 资源
- 批准号:
9754141 - 财政年份:2015
- 资助金额:
$ 69.94万 - 项目类别:
The Health ePeople Resource for Mobilized Research
用于动员研究的 Health ePeople 资源
- 批准号:
9150592 - 财政年份:2015
- 资助金额:
$ 69.94万 - 项目类别:
The Health ePeople Resource for Mobilized Research
用于动员研究的 Health ePeople 资源
- 批准号:
9064457 - 财政年份:2015
- 资助金额:
$ 69.94万 - 项目类别:
Mechanistic Relationships Between Ethanol and Human Atrial Fibrillation
乙醇与人类心房颤动之间的机制关系
- 批准号:
8837551 - 财政年份:2014
- 资助金额:
$ 69.94万 - 项目类别:
Mechanistic Relationships Between Ethanol and Human Atrial Fibrillation
乙醇与人类心房颤动之间的机制关系
- 批准号:
9249436 - 财政年份:2014
- 资助金额:
$ 69.94万 - 项目类别:
Mechanistic Relationships Between Ethanol and Human Atrial Fibrillation
乙醇与人类心房颤动之间的机制关系
- 批准号:
9459281 - 财政年份:2014
- 资助金额:
$ 69.94万 - 项目类别:
The Health ePeople Resource for Mobilized Research
用于动员研究的 Health ePeople 资源
- 批准号:
9334228 - 财政年份:
- 资助金额:
$ 69.94万 - 项目类别:
The Health ePeople Resource for Mobilized Research
用于动员研究的 Health ePeople 资源
- 批准号:
9754145 - 财政年份:
- 资助金额:
$ 69.94万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 69.94万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 69.94万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 69.94万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 69.94万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 69.94万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 69.94万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 69.94万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 69.94万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 69.94万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 69.94万 - 项目类别:
Research Grant