The Health ePeople Resource for Mobilized Research

用于动员研究的 Health ePeople 资源

• 批准号: 9334228
• 负责人: GREGORY M MARCUS
• 金额: $ 150.39万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9334228
• 关键词: Architecture; Award; Behavior; Cardiovascular Diseases; Cellular Phone; Characteristics; Clinical Research; Cohort Studies; Computerized Medical Record; Consent; Custom; Data; Data Analytics; Data Base Management; Data Collection; Databases; Devices; Disease; Electronic Health Record; Emerging Technologies; Engineering; Enrollment; Funding; Genetic; Geography; Goals; Health; Health Technology; Human Resources; Image; Institutional Review Boards; Internet; Intervention Trial; Medical Records; Methods; Modeling; Observational Study; Outcome; Participant; Patient Outcomes Assessments; Patient Self-Report; Persons; Population; Prevention strategy; Privacy; Prospective Studies; Randomized; Recruitment Activity; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Safety; Security; Silicon; Structure; Surveys; System; Talents; Technology; Testing; Time; Vision; Work; base; clinical efficacy; cohort; cost effective; dashboard; data integration; data management; data visualization; design; digital; epidemiology study; flexibility; high standard; improved; industry partner; interest; interoperability; mHealth; mobile application; mobile computing; public-private partnership; randomized trial; research study; sensor; success; tool; user-friendly; validation studies

RESOURCE CORE— PROJECT SUMMARY/ABSTRACT We seek to create the Health ePeople Resource, a nimble, readily-accessible, and reliable infrastructure to conduct mHealth research. This effort will build on the current Health eHeart Study, an internet-based clinical research platform that has enrolled more than 20,000 engaged participants from around the world. Although initially developed to study cardiovascular disease, Health eHeart is in use by investigators from multiple fields, and helps us jumpstart many of the objectives set out in the current RFA. We have successfully implemented a user-friendly interface built to collect patient-reported outcomes, validated survey data, and integrations with multiple sensors, devices, and apps; we have an IRB approved system using modular electronic consenting; we have over 20,000 deeply involved participants interested in contributing to mHealth research; we have developed ways for external investigators to utilize and enroll their own participants in a customizable fashion; we have developed a study management portal (including a real-time dashboard and participant characteristic- based filtering system) and a flexible messaging system that can be utilized by external investigators; we have built a database and data management system constructed to adhere to the highest standards of privacy, security, and reliability; and we have iterated and adapted the platform to take advantage of emerging technology and cutting-edge methods. Building from these strengths, we are ready to fully leverage the opportunities afforded by this award, transforming the Health eHeart Study into a general Health ePeople Resource. The Resource Core will be responsible for the following objectives: to expand, improve and iterate upon our participant-facing portal designed to remotely collect self-reported, medical record, device, sensor and mobile data; to expand and improve a redundant, scalable, and fault-tolerant backend and database to reliably curate large quantities of structured and unstructured data; to expand, improve, iterate and maintain a readily accessible interface that enables rapid study implementation for a variety of investigators to customize and utilize a participant portal and backend and database for their mHealth research; to expand, improve and iterate an infrastructure for data analytics, data visualization, and interoperability with external databases; to expand and maintain a cohort of research participants engaged in mHealth that is constructed to provide rapid and customizable selection for observational studies, validation studies, and randomized interventional trials; and finally, to develop and deploy a model to financially and technologically sustain the Health ePeople Resource beyond the proposed funding period.

资源核心-项目概要/摘要 我们寻求创建健康ePeople资源，这是一个灵活，易于访问和可靠的基础设施， 进行移动健康研究。这项工作将建立在目前的健康电子心脏研究，一个基于互联网的临床 该研究平台已招募了来自世界各地的20，000多名参与者。虽然 最初是为了研究心血管疾病而开发的，健康eHeart被来自多个领域的研究人员使用， 并帮助我们启动当前RFA中设定的许多目标。我们成功地实施了一项 用户友好的界面，用于收集患者报告的结局、经验证的调查数据，并与 多个传感器、设备和应用程序;我们有一个IRB批准的系统，使用模块化电子同意; 我们有超过20，000名有兴趣为移动健康研究做出贡献的参与者;我们有 为外部研究者开发了以可定制的方式利用和招募他们自己的参与者的方法; 我们开发了一个研究管理门户（包括实时仪表板和参与者特征- 基于过滤系统）和一个灵活的消息传递系统，可供外部调查人员使用;我们有 建立了一个数据库和数据管理系统，以遵守最高的隐私标准， 安全性和可靠性;我们已经迭代和调整了平台，以利用新兴的 技术和尖端方法。在这些优势的基础上，我们已准备好充分利用 该奖项提供的机会，将健康eHeart研究转变为一般健康ePeople resource.资源核心将负责实现以下目标：扩大、改进和 在我们面向参与者的门户网站上，设计用于远程收集自我报告、医疗记录、设备、传感器 和移动的数据;扩展和改进冗余、可扩展和容错的后端和数据库， 可靠地管理大量的结构化和非结构化数据;扩展、改进、扩展和维护 易于访问的界面，使各种研究者能够快速实施研究， 并利用参与者门户网站和后端和数据库为他们的mHealth研究;扩大，改善和 提供数据分析、数据可视化以及与外部数据库互操作的基础架构; 扩大和维持一个研究参与者的队列，从事移动健康，是为了提供快速 可定制选择观察性研究、验证性研究和随机干预性试验; 最后，开发和部署一个模型，以在财政和技术上维持健康电子人 拟议供资期后的资源。