UZIMA-DS: UtiliZing health Information for Meaningful impact in East Africa through Data Science

项目摘要--总体构成部分 非洲是世界上最年轻的大陆，其60%的人口年龄在25岁以下。之间的跨度 从早年到成年是生物、环境和心理社会事件的关键窗口 可以显著影响长期的uzima，这在斯瓦希里语中意味着健康/福祉。再加上最近的 在非洲，技术的进步和收集的海量数据是前所未有的 有机会利用数据科学来确定和改善非洲年轻人的健康轨迹。然而， 巨大的分析和计算障碍仍然存在，阻碍了我们利用这些信息进行改变的能力 社区和个人层面的关怀。我们建议的研究中心UZIMA-DS旨在改变这一点 通过数据科学利用卫生信息在东非产生有意义的影响的叙述。我们将创造 可扩展且可持续的平台，可将新方法应用于数据同化和高级人工智能 基于智能(AI)/机器学习(ML)的方法作为早期预警系统，以解决关键问题 在两个领域影响非洲青年的健康问题：孕产妇、新生儿和儿童健康以及心理健康 健康。我们的中心解决了数据科学翻译领域的三个关键需求：1) 协调多模式数据来源，以进行有意义的使用和分析；2)利用 使用基于AI/ML的方法通过预测建模来识别轨迹的数据；以及3)与关键字接触 为利益攸关方确定这些模式在目标社区的传播和可持续性的途径。 对于我们的母婴健康研究(项目1)，我们将利用 肯尼亚，包括两个人口监测系统、队列研究和医院数据，以开发和 验证基于AI/ML的预测模型以识别处于不良妊娠高危状态的育龄妇女 结局(如妊娠高血压综合征、低出生体重)和晚年的非传染性疾病 以及面临未来不良生活结果风险的儿童(例如，发育迟缓)。为我们的心理健康研究 (项目2)，利用现有的监控数据以及新的移动技术(例如，移动应用程序、 可穿戴设备)，用于开发现有和新的基于AI/ML的预测模型，以识别青少年和 肯尼亚面临抑郁和自杀念头的年轻医护人员。我们的中心和项目将是 由管理核心、数据管理和分析核心以及传播和可持续性支持 核心，这将促进与多部门利益攸关方的接触，以确定可持续的模式传播 进入目标社区的途径。最终，我们的工作将使非洲研究人员能够发扬 UZIMA-DS Hub通过建设可持续的基础设施来满足非洲人持续和不断变化的卫生需求， 专业知识和伙伴关系，以产生长期影响。UZIMA-DS集线器可以作为可扩展的模型 与更大的DS-I联盟合作的其他国家和卫生领域，以改变非洲的医疗服务提供， 确保当前和未来几代非洲人能够实现乌兹马。

PROJECT SUMMARY – Overall Component Africa is the youngest continent in the world, with 60% of its population under the age of 25. The span between early life to young adulthood represents a critical window where biological, environment and psychosocial events can significantly impact long- term uzima, which means health/well-being in Swahili. Coupled with the recent technological advances and the enormous volumes of data collected in Africa, there is an unprecedented opportunity to leverage data science to identify and improve the health trajectories of young Africans. However, significant analytical and computational barriers persist that impede our ability to use this information to change care at the community and individual level. Our proposed Research Hub, UZIMA-DS, aims to change this narrative by UtiliZing health Information for Meaningful impact in East Africa through Data Science. We will create a scalable and sustainable platform to apply novel approaches to data assimilation and advanced artificial intelligence (AI)/machine learning (ML)-based methods to serve as early warning systems to address critical health issues impacting young Africans in two domains: maternal, newborn and child health and mental health. Our Hub addresses three critical needs across the translational spectrum of data science: 1) Harmonization of multimodal data sources for meaningful use and analyses; 2) Leveraging temporal patterns of data to identify trajectories through prediction modeling using AI/ML-based methods; and 3) Engaging with key stakeholders to identify pathways for dissemination and sustainability of these models into target communities. For our Maternal and Child Health Study (Project 1), we will leverage the large and diverse existing data sets in Kenya, including two demographic surveillance systems, cohort studies and hospital data, to develop and validate AI/ML-based prediction models to identify women of childbearing age at high risk for poor pregnancy outcomes (e.g., pregnancy-induced hypertension, low birthweight) and non-communicable diseases later in life and children at risk of future poor life outcomes (e.g., developmental delays). For our Mental Health Study (Project 2), leverage existing surveillance data as well as novel mobile technologies (e.g., mobile apps, wearables) for the development of existing and new AI/ML-based prediction models to identify adolescents and young healthcare workers at risk of depression and suicide ideation in Kenya. Our Hub and Projects will be supported by an Admin Core, Data Management and Analysis Core, and a Dissemination and Sustainability Core, which will facilitate engagement with multisectoral stakeholders to identify sustainable model dissemination pathways into target communities. Ultimately, our work will empower African researchers to carry forward the UZIMA-DS Hub to address on-going and evolving health needs of Africans by building sustainable infrastructure, expertise, and partnerships for long-lasting impact. The UZIMA-DS Hub can serve as a model that can be scaled to other countries and health domains with the greater DS-I consortium to transform care delivery in Africa, ensuring that current and future generations of Africans can achieve uzima.