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2/3 Akili: Phenotypic and genetic characterization of ADHD in Kenya and South Africa

2/3 Akili：肯尼亚和南非 ADHD 的表型和遗传特征

基本信息

批准号：
10637187
负责人：
Amina Abubakar Ali
金额：
$ 53.71万
依托单位：
AGA KHAN UNIVERSITY (KENYA)
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2028-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10637187
关键词：
Acceleration Address Africa African Age Architecture Area Attention Attention deficit hyperactivity disorder Award Behavioral Biological Caring Child Clinical Cognitive Collection DNA Data Data Collection Development Diagnosis Disease Education Enrollment Ensure Equity European ancestry Fruit Funding Generalized Anxiety Disorder Genes Genetic Genetic Research Genetic Risk Genetic study Genomics Genotype Goals Health Heterogeneity Hyperactivity Impulsivity Intellectual functioning disability International Interview Kenya Lead Leadership Link Maps Medical Medical History Mind Mood Disorders National Institute of Mental Health Neurodevelopmental Disorder Occupational Outcome Parents Participant Phenotype Population Raven Research Resources Saliva Sample Size Sampling Schedule School-Age Population Scientist Severities Site South Africa South African Speed Students Sustainable Development Training United States Variant Work autism spectrum disorder case control clinically relevant cohort design diagnostic criteria doctoral student executive function exome exome sequencing gene discovery genetic architecture genome wide association study genome-wide improved insight member neuropsychiatric disorder neuropsychiatry non-verbal phenotypic data polygenic risk score psychiatric genomics rare variant recruit risk sharing risk variant sex skills social success tool trait

项目摘要

PROJECT SUMMARY ADHD is a common neurodevelopmental disorder that includes attention difficulty, impulsivity, and hyperactivity. The diagnosis is associated with many challenges to educational, occupational, and health outcomes, particularly when untreated. Genetic studies of ADHD have the potential to clarify the disorder’s biological underpinnings, its heterogeneity, and its relationship to other neuropsychiatric diagnoses. However, genetic research into ADHD lags in terms of: (1) sample size, (2) ancestral diversity, and (3) consideration of phenotypic heterogeneity. Akili is designed to address all three of these critical gaps. Akili (the Swahili term for “mind”) will enroll 6,000 children in Kenya and South Africa – 4,000 with a confirmed diagnosis of ADHD and 2,000 age- and ancestry-matched controls. All participants will complete a detailed behavioral, cognitive, and medical phenotyping battery, and provide a DNA sample. We will genetically characterize all 6,000 participants using exome sequencing and genome-wide genotyping, and make all Akili data and materials publicly available through the NIMH. Akili data will nearly double the number of ADHD cases available for exome sequencing analysis and provide a 20% addition to the current PGC-ADHD GWAS activity. It will be by far the largest contributor of diverse ancestry data to either analysis. Akili will generate a research resource of international value, and provide the first large-scale characterization of ADHD in the African context.

项目总结