Investigation of Embodiment for Upper Limb Amputees

上肢截肢者的躯体化研究

• 批准号: 10490285
• 负责人: Jacob Segil
• 金额: --
• 依托单位: VA EASTERN COLORADO HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-11-01 至 2025-10-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10490285
• 关键词: Address; Affect; Algorithms; Amputation; Amputees; Anxiety; Appearance; Area; Award; Back; Biomechanics; Body part; Chronic; Clinical; Cosmetics; Data; Data Collection; Data Set; Device or Instrument Development; Devices; Disabled Persons; Dorsal; Economics; Electrodes; Esthesia; Feedback; Future; Goals; Hand; Health Care Research; Illusions; Impairment; Individual; Investigation; Investments; K-Series Research Career Programs; Laboratories; Laboratory Study; Lead; Limb Prosthesis; Limb structure; Location; Measurement; Measures; Mechanics; Medical Device; Medical center; Mental Depression; Mentors; Mentorship; Methodology; Methods; Mission; Monitor; Myoelectric prosthesis; Numbness; Outcome Measure; Patients; Peripheral Nerve Stimulation; Peripheral Nerves; Persons; Physical Medicine; Physical Rehabilitation; Physiological; Procedures; Prosthesis; Protocols documentation; Psychophysics; Publications; Recording of previous events; Research; Rest; Rubber; Scientist; Sensory; Services; Social isolation; Surface; Surveys; System; Tactile; Technology; Testing; Time; Training; Travel; United States Department of Veterans Affairs; Upper Extremity; Veterans; Work; career; design; exhaustion; experience; experimental study; grasp; improved; improved functioning; invention; limb amputation; multimodality; myoelectric control; neural implant; novel; physically handicapped; pressure; prosthetic hand; psychosocial; recruit; rehabilitation research; relating to nervous system; research and development; restoration; self esteem; sensor; sensory feedback; sensory prosthesis; somatosensory; tool; transradial amputee

Project Summary Today, prosthetic hands are numb. They provide no tactile or proprioceptive sensory information back to the user. The lack of sensory feedback has been shown to reduce the utility of a prosthesis by half. The prosthesis is seen as a tool, not as an incorporated part of the body schema. Only now are there chronically-implantable technologies which can provide physiologically appropriate sensory feedback to upper limb amputees to recreate tactile and proprioceptive percepts. These sensations are the building blocks to enable the embodiment of the device. Furthermore, newly developed outcome measures are now available which can detail the improved embodiment such neural interfaces can create. My mission is to enable the embodiment of artificial devices using peripheral nerve stimulation and thereby close the gap between the experience of our intact physiological systems and those using prosthetic remedies. This investigation of embodiment for upper limb amputees is organized into three main areas of work including 1) normative data collection, 2) device development, and 3) characterization of embodiment using peripheral nerve stimulation. The normative data collection will quantify the embodiment of conventional cosmetic, body-powered, and myoelectric prosthetic hand options using a modified Rubber Hand Illusion protocol (Specific Aim 1). This thrust will ask how does the amount of embodiment vary among conventional prosthetic hands as well as probe the relationship between agency and embodiment. The device development project entails the design of multi-modal sensors in order to study full-hand embodiment (Specific Aim 2). The ability to measure and then elicit sensation on the passive surfaces of the hand (palm, ulnar border, and dorsal surface) has never been explored. Here, a multi-modal sensor which can detect proximity, contact, and force will be integrated into a commercially available prosthetic hand in order to provide detailed measurements across the palm, ulnar border, and dorsal surfaces in order to study embodiment in more depth. Finally, the characterization of embodiment using peripheral nerve stimulation will take place over a multiple subject factorial experiment which quantifies the effects of quantity and spatial parameters of the peripheral nerve stimulation on the embodiment of prosthetic hands (Specific Aim 3). This study asks what somatosensory percepts from the hand are most critical for embodiment by varying the parameters of the peripheral nerve stimulation (quantity and spatiality) and measuring the level of embodiment in each case. This investigation will be the first thorough (multiple subjects with peripheral nerve interfaces), systematic (paired factorial design), and exhaustive (using all electrodes in the neural interface) study to be performed. Finally, an additional goal to the scientific mission of this proposal is the creation of the Neural Interface and Sensory Restoration Laboratory in the Rocky Mountain Regional VA Medical Center. I will direct this laboratory to be a complementary entity to Dr. Tyler’s Functional Neural Interface Laboratory to study peripheral nerve interfaces with upper limb amputees in the VA RR&D division. Now, more advanced methodologies can be explored and more scientific breakthroughs can be initiated with the goal of providing Veterans with amputation an artificial limb, as opposed to just a prosthetic tool.

项目摘要 今天，假肢很麻木。他们没有提供触觉或本体感知感官 向用户提供信息。缺乏感觉反馈可以减少实用程序 假体的一半。假体被视为一种工具，而不是身体的合并部分 模式。只有现在才有可以提供长期植入的技术 在物理上适当的感觉反馈上肢截肢者以重新创建触觉和 本体感知感。这些感觉是能够实现的基础 设备。此外，现在可以使用新开发的结果指标 详细说明改进的实施例可以创建这种神经界面。我的任务是启用 使用外周神经刺激对人造装置的实施例，从而缩小了间隙 在我们完整的生理系统的经验与使用假肢疗法的经验之间。 实施方案的上肢截肢者的投资被组织成三个主要领域 工作包括1）正常数据收集，2）设备开发和3）表征 使用周围神经刺激的实施例。普通数据收集将量化 常规化妆品，身体动力和肌电假肢的实施例 使用改良的橡胶手幻觉协议（特定目标1）的选项。这个推力会问 传统的假肢以及 探测代理与体现之间的关系。设备开发项目 需要设计多模式传感器以研究全手实施例（特定目的 2）。测量并在手的被动表面上引起感觉的能力（棕榈， 从未探索过尺骨和背面）。这里是一个多模式传感器 可以检测到邻近，接触和力将集成到市售中 假肢手，以提供棕榈，尺骨边界的详细测量和 背面以更深入研究实施方案。最后，表征 使用周围神经刺激的实施例将在多个主题阶乘上进行 量化周围数量和空间参数的影响的实验 假肢的实施方案上的神经刺激（特定目标3）。这项研究问 从手中使用哪种感觉感知，对于实施方案至关重要。 周围神经刺激的参数（数量和空间性）并测量 在每种情况下的实施水平。这项投资将是第一个透彻的（多个主题 具有周围神经界面），系统的（配对阶乘设计）和详尽（使用所有 在神经界面中的电极）研究。 最后，该提案的科学任务的另一个目标是创建神经 落基山地区VA医疗的界面和感觉恢复实验室 中心。我将指示该实验室成为泰勒博士功能的完整实体 神经界面实验室研究周围神经界面，上肢截肢者 VA RR＆D部门。现在，可以探索更高级的方法，更多 可以以科学突破来为退伍军人提供截肢和 人造肢体，而不是假肢工具。