Investigation of Embodiment for Upper Limb Amputees

上肢截肢者的躯体化研究

• 批准号: 10290316
• 负责人: Jacob Segil
• 金额: --
• 依托单位: VA EASTERN COLORADO HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-11-01 至 2025-10-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10290316
• 关键词: Address; Affect; Algorithms; Amputation; Amputees; Anxiety; Appearance; Area; Award; Back; Biomechanics; Body part; Chronic; Clinical; Cosmetics; Data; Data Collection; Data Set; Device or Instrument Development; Devices; Disabled Persons; Dorsal; Economics; Electrodes; Esthesia; Feedback; Future; Goals; Hand; Health Care Research; Illusions; Impairment; Individual; Investigation; Investments; K-Series Research Career Programs; Laboratories; Laboratory Study; Lead; Limb Prosthesis; Limb structure; Location; Measurement; Measures; Mechanics; Medical Device; Medical center; Mental Depression; Mentors; Mentorship; Methodology; Methods; Mission; Monitor; Myoelectric prosthesis; Numbness; Outcome Measure; Patients; Peripheral Nerve Stimulation; Peripheral Nerves; Physical Medicine; Physical Rehabilitation; Physiological; Procedures; Prosthesis; Protocols documentation; Psychophysics; Publications; Recording of previous events; Research; Rest; Rubber; Scientist; Sensory; Services; Social isolation; Surface; Surveys; System; Tactile; Technology; Testing; Time; Training; Travel; United States Department of Veterans Affairs; Upper Extremity; Veterans; Work; career; design; exhaustion; experience; experimental study; grasp; improved; improved functioning; invention; limb amputation; multimodality; myoelectric control; neural implant; novel; physically handicapped; pressure; prosthetic hand; psychosocial; recruit; rehabilitation research; relating to nervous system; research and development; restoration; self esteem; sensor; sensory feedback; sensory prosthesis; somatosensory; tool; transradial amputee

Project Summary Today, prosthetic hands are numb. They provide no tactile or proprioceptive sensory information back to the user. The lack of sensory feedback has been shown to reduce the utility of a prosthesis by half. The prosthesis is seen as a tool, not as an incorporated part of the body schema. Only now are there chronically-implantable technologies which can provide physiologically appropriate sensory feedback to upper limb amputees to recreate tactile and proprioceptive percepts. These sensations are the building blocks to enable the embodiment of the device. Furthermore, newly developed outcome measures are now available which can detail the improved embodiment such neural interfaces can create. My mission is to enable the embodiment of artificial devices using peripheral nerve stimulation and thereby close the gap between the experience of our intact physiological systems and those using prosthetic remedies. This investigation of embodiment for upper limb amputees is organized into three main areas of work including 1) normative data collection, 2) device development, and 3) characterization of embodiment using peripheral nerve stimulation. The normative data collection will quantify the embodiment of conventional cosmetic, body-powered, and myoelectric prosthetic hand options using a modified Rubber Hand Illusion protocol (Specific Aim 1). This thrust will ask how does the amount of embodiment vary among conventional prosthetic hands as well as probe the relationship between agency and embodiment. The device development project entails the design of multi-modal sensors in order to study full-hand embodiment (Specific Aim 2). The ability to measure and then elicit sensation on the passive surfaces of the hand (palm, ulnar border, and dorsal surface) has never been explored. Here, a multi-modal sensor which can detect proximity, contact, and force will be integrated into a commercially available prosthetic hand in order to provide detailed measurements across the palm, ulnar border, and dorsal surfaces in order to study embodiment in more depth. Finally, the characterization of embodiment using peripheral nerve stimulation will take place over a multiple subject factorial experiment which quantifies the effects of quantity and spatial parameters of the peripheral nerve stimulation on the embodiment of prosthetic hands (Specific Aim 3). This study asks what somatosensory percepts from the hand are most critical for embodiment by varying the parameters of the peripheral nerve stimulation (quantity and spatiality) and measuring the level of embodiment in each case. This investigation will be the first thorough (multiple subjects with peripheral nerve interfaces), systematic (paired factorial design), and exhaustive (using all electrodes in the neural interface) study to be performed. Finally, an additional goal to the scientific mission of this proposal is the creation of the Neural Interface and Sensory Restoration Laboratory in the Rocky Mountain Regional VA Medical Center. I will direct this laboratory to be a complementary entity to Dr. Tyler’s Functional Neural Interface Laboratory to study peripheral nerve interfaces with upper limb amputees in the VA RR&D division. Now, more advanced methodologies can be explored and more scientific breakthroughs can be initiated with the goal of providing Veterans with amputation an artificial limb, as opposed to just a prosthetic tool.

项目摘要 如今，假手已经麻木了。它们不提供触觉或本体感觉 将信息返回给用户。缺乏感官反馈已被证明降低了效用 把假肢的重量减半。假肢被视为一种工具，而不是身体的一个组成部分。 架构。只有现在才有长期可植入的技术可以提供 向上肢截肢者提供生理上合适的感觉反馈，以重建触觉和 本体知觉。这些感觉是使具体化的 这个装置。此外，现在已经有了新开发的成果衡量标准，它可以 详细说明这种神经接口可以创建的改进的实施例。我的使命是使 体现了使用周围神经刺激的人工设备，从而缩小了差距 我们完整的生理系统的体验和使用假肢治疗的体验之间的差异。 这项关于上肢截肢者具体化的调查分为三个主要领域 工作包括1)标准化数据收集，2)设备开发，以及3)表征 体现为使用周围神经刺激。规范性数据收集将量化 传统美容、身体动力和肌电假手的体现 使用修改的橡皮手错觉方案的选项(特定目标1)。这股推力会问 化身的数量在传统的假手以及 探讨代理与体现的关系。设备开发项目 需要设计多模式传感器，以研究全手体现(特定目标 2)。测量并随后在手的被动表面(手掌， 尺骨边缘和背侧表面)从未被探索过。这里，一种多模式传感器，它 可以检测到接近，接触和力量将被集成到商业上可用的 假手，以便提供跨越手掌、尺骨边界和 以便更深入地研究背部表面的体现。最后，《红楼梦》的特点 使用周围神经刺激的实施将在多个受试者因素上进行 量化外周的数量和空间参数影响的实验 神经刺激对假手的体现(具体目标3)。这项研究要求 从手中感知到的什么体感对肉体的体现是最关键的 周围神经刺激参数(量和空间)及测量 在每种情况下的实施级别。这次调查将是第一次彻底的(多个主题) 与周围神经接口)、系统(配对析因设计)和穷举(使用所有 神经接口中的电极)进行研究。 最后，这项提议的科学任务的另一个目标是创造神经 落基山地区退伍军人医疗中心的接口和感觉恢复实验室 中心。我将指示这个实验室成为泰勒博士功能的补充实体 神经接口实验室将研究上肢截肢者的周围神经接口 退伍军人事务部研发部门。现在，可以探索更高级的方法和更多 可以启动科学突破，目标是为退伍军人提供截肢和 假肢，而不仅仅是假肢工具。