Integrated Early Intervention for Alcohol Use Disorder and Posttraumatic Stress Disorder Following Sexual Assault- K23 - Supplement

性侵犯后酒精使用障碍和创伤后应激障碍的综合早期干预 - K23 - 补充

• 批准号: 10623382
• 负责人: Christine Kathryn Hahn
• 金额: $ 5.31万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10623382
• 关键词: Address; Adult; Affect; Alcohol consumption; Anxiety; Area; Behavior; Behavior Therapy; Behavioral Mechanisms; Childbirth; Clinical; Clinical Trials; Cognition; Cognitive Therapy; Data; Data Analyses; Data Collection; Development; Early Intervention; Ecological momentary assessment; Enrollment; Ensure; Environmental Monitoring; Event; Evidence based intervention; Evidence based treatment; Exposure to; Feedback; Focus Groups; Future; Goals; Grant; Health; Health Care Costs; Impairment; Intervention; Knowledge; Lead; Life; Link; Manuscripts; Measures; Mediator of activation protein; Medical; Mental Depression; Mental Health; Mental disorders; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Mission; Modification; National Institute on Alcohol Abuse and Alcoholism; Outcome; Outcomes Research; Participant; Patient Recruitments; Pattern; Persons; Phase; Post-Traumatic Stress Disorders; Process; Provider; Public Health; Randomized; Randomized Controlled Trials; Reporting; Research; Research Assistant; Research Ethics; Research Personnel; Science; Series; Severities; South Carolina; Standardization; Symptoms; Testing; Time; Training; Trauma; Treatment Protocols; Treatment outcome; Universities; Woman; Writing; aged; alcohol craving; alcohol intervention; alcohol research; alcohol risk; alcohol use disorder; assault; behavior change; brief alcohol intervention; career; career development; clinically significant; comorbidity; craving; design; drinking; effective intervention; emotion regulation; evidence base; experience; hazardous drinking; improved; insight; intervention effect; novel; open label; patient oriented; post intervention; programs; recruit; reduce symptoms; reduced alcohol use; revictimization; service providers; sexual assault; sexual risk taking; skills; substance use; therapy development; trauma exposure; traumatic event

ABSTRACT The overall objective of the proposed Mentored Patient-Oriented Research Career Development Award (K23) is to support Dr. Christine Hahn in acquiring the skills necessary to become an independent investigator with a program of research focused on the development of interventions for alcohol use disorder (AUD) and comorbid mental health conditions, in particular posttraumatic stress disorder (PTSD). AUD and PTSD frequently co-occur among people who experience traumatic life events, such as sexual assault. However, there is a lack of established evidence-based interventions to reduce AUD and PTSD among recent victims. The current study directly addresses this clinical gap by testing the novel integration of two, evidence-based, cognitive-behavioral interventions for AUD and PTSD to be delivered in five sessions beginning in the six weeks following sexual assault. Dr. Hahn adapted the intervention using an iterative process informed by expert feedback (Phase 1) and is conducting an open label trial (n = 10) to finalize the treatment protocol (Phase 2). In Phase 3, the treatment protocol will be tested in a pilot randomized controlled trial (RCT) among recent sexual assault victims (n = 54) to evaluate feasibility and preliminary efficacy in reducing AUD severity and PTSD symptoms. Ecological momentary assessments (EMA) will be used to assess alcohol use, craving, and affect during the five-week treatment phase. Administrative support is needed to ensure the pilot RCT is successfully implemented during the critical life events of childbirth and subsequent primary caretaking responsibilities. Administrative support will be used to hire a research assistant to complete essential study tasks including participant recruitment, administering study assessments, providing participant renumeration, and monitoring ecological momentary assessment data collection. Acquiring a research assistant will result in more successful recruitment, enrollment, and participant completion of the study. The supplement will ensure the PI continues to focus on receiving dedicated mentorship and achieves the following career goals: (1) Gain new knowledge in AUD mechanisms and interventions; (2) Develop skills in designing and implementing clinical trials for AUD and co-occurring PTSD; (3) Increase statistical skills with multilevel and longitudinal data analyses; (4) Enhance understanding of research ethics; and (5) Continue professional development through manuscript writing, professional presentations, and grant writing. Dr. Hahn is completing K23 activities at the Medical University of South Carolina, which has a strong track record of commitment to the advancement of early-stage AUD investigators. Administrative support to complete the K23 activities will ultimately prepare Dr. Hahn to lead a program of rigorously-designed AUD treatment outcome research.

摘要