Cancer Control and Population Science

癌症控制与人口科学

• 批准号: 10491109
• 负责人: SHIRAZ I. MISHRA
• 金额: $ 7.05万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-26 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10491109
• 关键词: Address; Air; American Indians; Analgesics; Anthropology; Arizona; Arsenic; Arts; Behavior Therapy; Behavioral; Behavioral Sciences; Bioinformatics; Biological Markers; Biometry; Breast; Cancer Center; Cancer Center Support Grant; Cancer Control; Caring; Catchment Area; Cervical Cancer Screening; Cervix Uteri; Clinical; Clinical Trials; Collaborations; Colorado; Colorectal; Colorectal Cancer; Communities; Community Clinical Oncology Program; Community Medicine; Community Outreach; Comprehensive Cancer Center; Contracts; Cultural Diversity; DNA Damage; Data; Dermatology; Development; Disease; Doctor of Philosophy; Early Diagnosis; Education; Endometrial; Engineering; Environmental Exposure; Environmental Health; Environmental Pollution; Environmental Risk Factor; Epidemiology; Family Practice; Funding; Future; Gallbladder; Genetic; Genomics; Genotype; Geography; Goals; Grant; Guidelines; Health Services; Healthcare; Hepatitis C virus; Hispanic; Hispanic Americans; Human Papilloma Virus Vaccination; Human Papillomavirus; Incidence; Infrastructure; Internal Medicine; Intervention; Intervention Studies; Journals; Ketorolac; Kidney; Knowledge; Length; Liver; Lung; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Malignant neoplasm of lung; Malignant neoplasm of ovary; Metals; Minority; Molecular; Molecular Epidemiology; Morbidity - disease rate; Mutation; NCI-Designated Cancer Center; New Mexico; Not Hispanic or Latino; Oncologist; Outcome; Ovarian; Particulate; Pathology; Patients; Pediatrics; Peer Review; Personal Satisfaction; Pharmacy facility; Planet Earth; Population; Population Genetics; Population Heterogeneity; Population Sciences; Populations at Risk; Primary Health Care; Prostate; Publications; Publishing; Registries; Research; Research Institute; Resource Sharing; Resources; Risk; Risk Behaviors; Risk Factors; Risk Reduction; Rural; Rural Community; Rural Population; Science; Screening for cancer; Smoker; Testing; Therapeutic Human Experimentation; Tissues; Tobacco; Training; Translations; Underserved Population; Universities; Utah; Virus; Zinc supplementation; base; cancer care; cancer health disparity; cancer risk; cellular oncology; cohort; college; colorectal cancer screening; community based participatory research; community center; community engaged research; community engagement; community intervention; cooking; dissemination research; early detection biomarkers; evidence base; follow-up; health disparity; health economics; implementation research; improved; improved outcome; male; medical schools; melanoma; member; methylation biomarker; molecular oncology; mortality; mortality disparity; multi-ethnic; neoplasm registry; physical inactivity; policy recommendation; population based; population health; programs; prospective; racial and ethnic; ranpirnase; respiratory; risk prediction; screening; screening disparities; screening guidelines; socioeconomics; survivorship; therapeutic target; tribal Nation; tumor; tumor registry; underserved minority; working group

ABSTRACT: Cancer Control and Population Sciences (CCPS) is a transdisciplinary research program incorporating expertise in surveillance, epidemiology, population genetics, anthropology, behavioral science, health economics, dissemination and implementation research, biostatistics, health services, and environmental health across the cancer continuum. CCPS serves as the nexus for cancer control and population/community research within the University of New Mexico Comprehensive Cancer Center (UNMCCC) and it’s catchment area, the State of New Mexico (NM) - one of the five ”majority-minority” states in the US. The catchment area’s racial/ethnic diverse population have substantial socioeconomic, healthcare, and geographic challenges, all contributing to tremendous cancer disparities and inequities. Within this context of the catchment area, the overarching goals of CCPS are to conduct high impact research and disseminate interventions to reduce cancer risk, morbidity, mortality and disparity in the multiethnic, culturally diverse, and underserved populations of NM and beyond. To achieve these goals CCPS proposes three specific aims: (1) improve cancer risk prediction and reduce cancer risk; (2) define screening determinants and advance guideline concordant cancer screening; and, (3) define the treatment and behavioral determinants of living with, through, and beyond cancer to improve outcomes, patient well-being, and length of survival. These aims are aligned with two central themes, disparities and interventions, which provide a context and framework for addressing the needs of the catchment area and beyond. Unique strengths and major accomplishments include: early-detection methylation biomarkers associated with lung cancer risk; prospective assessment of the impact of HPV vaccination on cervical cancer incidence; engagement of American Indian communities to enhance colorectal cancer screening and molecular characterization of cancer; and, care transition from oncologists to primary care in rural NM supported by UNM’s Project ECHOTM. CCPS is led by Linda Cook, PhD (molecular epidemiology) and Shiraz Mishra, MBBS, PhD (behavioral /community interventions). CCPS has 29 members (24 Full, 5 Associate) from 6 Departments in the School of Medicine (Internal Medicine, Pediatrics, Family & Community Medicine, Pathology, and Dermatology); the Colleges of Population Health, Pharmacy, and Arts and Sciences (Departments of Engineering and Earth & Planetary Sciences); and the Lovelace Respiratory Research Institute. As of 9/1/2020, CCPS has $17.5M in total annual direct funding; $11.1M is peer-reviewed, and $2.5M is from the NCI. Additionally, CCPS has $2.7M in annual NCI direct funding through the NCI SEER contract for the New Mexico Tumor Registry and CCSG Supplements. The discoveries made in CCPS have resulted in 336 publications, of which 24% were intra-programmatic collaborations, 20% were inter-programmatic collaborations, 60% were collaborations with other cancer centers nationally, and 12% were published in high impact journals. CCPS has conducted 28 intervention studies with 1629 accruals.

摘要：癌症控制与人口科学（CCPS）是一个跨学科的研究项目 结合监测、流行病学、人口遗传学、人类学、行为科学方面的专业知识， 卫生经济学、传播和实施研究、生物统计学、卫生服务和环境 癌症连续体的健康状况。CCPS是癌症控制和人口/社区的纽带 新墨西哥州大学综合癌症中心（UNMCCC）及其流域内的研究 地区，新墨西哥州（NM）-美国五个"多数少数"州之一。集水区 种族/族裔多样化的人口面临着巨大的社会经济、医疗保健和地理挑战， 导致了巨大的癌症差异和不平等。在这个集水区范围内， CCPS的首要目标是进行高影响力的研究和传播干预措施，以减少癌症 风险，发病率，死亡率和差异的多民族，文化多样性，和服务不足的人口的NM 以及更远的地方为了实现这些目标，CCPS提出了三个具体目标：（1）改善癌症风险预测， 降低癌症风险;（2）定义筛查决定因素并推进指南一致的癌症筛查;以及， (3)定义与癌症共存、度过癌症和超越癌症的治疗和行为决定因素， 结果、患者健康和生存时间。这些目标与两个中心主题相一致， 和干预措施，为满足集水区的需要提供背景和框架， 超越。独特优势和主要成就包括：早期检测甲基化生物标志物 与肺癌风险相关; HPV疫苗接种对宫颈癌影响的前瞻性评估 发病率;美国印第安社区参与加强结直肠癌筛查和分子 癌症的特征;以及，在UNM的支持下，从肿瘤学家到农村NM初级保健的护理过渡 ECHOTM项目。CCPS由琳达库克博士（分子流行病学）和设拉子米什拉，MBBS，博士领导 （行为/社区干预）。CCPS有29名成员（24名正式成员，5名副成员），来自6个部门， 医学院（内科、儿科、家庭与社区医学、病理学和皮肤病学）; 人口健康学院、药学院、艺术与科学学院（工程系和地球与 行星科学）;和Lovelace呼吸研究所。截至2020年9月1日，CCPS在 年度直接资助总额; 1110万美元是同行评审的，250万美元来自NCI。此外，CCPS拥有270万美元的 通过NCI SEER合同为新墨西哥州肿瘤登记处和CCSG提供年度NCI直接资助 补充剂.在CCPS中的发现导致了336篇出版物，其中24%是计划内合作，20%是计划间合作，60%是与其他合作。 癌症中心，12%发表在高影响力的期刊上。CCPS进行了28次干预 包含1629项应计项目的研究。