Project 2: Aging Healthy Together: Precision Profiles of Resilience and Risk

项目 2：共同健康老龄化：复原力和风险的精确概况

• 批准号: 10491878
• 负责人: LEE RYAN
• 金额: $ 206.81万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10491878
• 关键词: Age; Age-associated memory impairment; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Area; Arizona; Baltimore; Biological Markers; Biometry; Black race; Blood; Brain; Categories; Characteristics; Chronic Disease; Cognition; Cognitive; Collaborations; Custom; Data; Dementia; Demographic Factors; Diabetes Mellitus; Diagnostic; Diet; Diffusion Magnetic Resonance Imaging; Disease; Education; Elderly; Ethnic group; Genetic Risk; Genomics; Glucose; Goals; Health; Heart Diseases; Hippocampus (Brain); Hispanic; Hispanic Populations; Human; Hypertension; Immune System Diseases; Impaired cognition; Independent Living; Individual; Individual Differences; Inflammation; Inflammatory; Intervention; Latino; Life; Life Style; Longevity; Longitudinal cohort; Magnetic Resonance Imaging; Measurement; Measures; Mediating; Memory; Mental Depression; Metabolic Diseases; Methods; Not Hispanic or Latino; Occupational; Participant; Pattern; Perfusion; Physical activity; Population; Population Heterogeneity; Productivity; Quality of life; Race; Recording of previous events; Rest; Risk; Risk Factors; Social Behavior; Social Interaction; Social isolation; Stress; Stroke; Structure; System; Therapeutic; Universities; Vascular Diseases; age related; aging brain; base; brain health; brain magnetic resonance imaging; cardiovascular insufficiency; clinical research site; cognitive change; cognitive function; executive function; genetic variant; healthspan; healthy lifestyle; improved; indexing; lifestyle factors; neuroimaging; novel; novel diagnostics; personalized approach; precision medicine; predictive modeling; processing speed; prognostic; psychosocial; recruit; resilience; sex; stressor; ultrasound

SUMMARY/ABSTRACT: Project 2 Aging Healthy Together: Profiles of Resilience and Risk Project 2 will obtain biomarkers related to four areas of risk for age-related cognitive impairment (ARCI) and cognitive decline, including Cardiovascular Insufficiency, Glucose Dysregulation, Inflammatory Profile, and Immune Dysfunction. We will determine whether profiles of risk and resilience in these four areas predict cognitive functioning among older adults and identify optimal predictive models for three race-ethnic groups – Hispanic/Latino, non-Hispanic Black, and non-Hispanic White. We will also determine whether the influence of these predictors on age-related cognition is mediated by functional and structural MRI measures, including diffusion MRI, resting state connectivity, perfusion, and hippocampal volume. In-depth assessments will be obtained from 1,620 participants, ages 50 to 79, at four clinical sites – Tucson (University of Arizona), Atlanta (Emory University), Miami (University of Miami), and Baltimore (Johns Hopkins University) – including demographics and lifestyle factors, psychosocial measures, biometric measures, blood biomarkers, MRI, carotid ultrasound, and genomics. Biomarkers and genetic risks will be used to predict individual differences in cognitive functioning (cross-sectionally) in three domains – memory, executive functions, and processing speed. Preliminary evidence for the impact of risk factors on longitudinal cognitive change will also be obtained. The proposed project is a critical step in achieving the ultimate goal of the Precision Aging Network (PAN) to develop a novel precision medicine diagnostic and prognostic system that will match an individual’s risk profile with a customized therapeutic and healthy lifestyle plan to maintain cognitive health across the lifespan. This goal requires understanding how categories of risk and their specific risk factors relate to cognitive functioning in order to identify novel targets for intervention and create therapeutic approaches for ARCI and cognitive decline. Matching cognitive healthspan with human lifespan will improve productivity and quality of life, extend independent living, and decrease the risk for Alzheimer’s disease (AD) and AD-related dementias (ADRD). PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

概要/摘要：项目2：共同健康老龄化：复原力和风险概况 项目2将获得与年龄相关认知障碍（ARCI）的四个风险领域相关的生物标志物， 认知功能下降，包括心血管功能不全、葡萄糖调节障碍、炎症特征，以及 免疫功能障碍。我们将确定这四个领域的风险和复原能力是否预示着 老年人的认知功能，并确定三个种族群体的最佳预测模型- 西班牙裔/拉丁美洲人、非西班牙裔黑人和非西班牙裔白色人。我们还将确定 这些与年龄相关的认知的预测因素是由功能和结构MRI测量介导的，包括 弥散MRI、静息状态连接、灌注和海马体积。深入评估将 从1,620名年龄在50到79岁的参与者中获得，他们来自四个临床中心-图森（亚利桑那大学），亚特兰大 （埃默里大学）、迈阿密（迈阿密大学）和巴尔的摩（约翰霍普金斯大学）--包括 人口统计学和生活方式因素，心理社会测量，生物测量，血液生物标志物，MRI， 颈动脉超声和基因组学生物标志物和遗传风险将被用来预测个体差异， 认知功能（横截面）在三个领域-记忆，执行功能和处理 速度风险因素对纵向认知变化影响的初步证据也将在 得到了 拟议的项目是实现精确老化网络（PAN）最终目标的关键一步， 开发一种新的精确医学诊断和预后系统，该系统将匹配个人的风险状况 通过定制的治疗和健康的生活方式计划，在整个生命周期内保持认知健康。这 目标要求了解风险类别及其特定风险因素与认知功能的关系 为了确定新的干预目标，并为ARCI和认知障碍创造治疗方法， 下降将认知健康寿命与人类寿命相匹配将提高生产力和生活质量， 独立生活，并降低阿尔茨海默病（AD）和AD相关痴呆（ADRD）的风险。 PHS 398/2590（Rev.06/09）